The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review

Abstract

The only long-term and cost-effective

T-Cell Correlates of Vaccine Efficacy after a Heterologous Simian Immunodeficiency Virus Challenge

“…As a result, many vaccine candidates under development aim to induce cellular immune responses against the virus (16,58,61). These strategies have been evaluated based on their immunogenicity, that is, their capacity to induce gamma interferon (IFN-␥) production by HIV-specific CD8 ϩ T cells (15,60).…”

Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

“…Recently, the identification of CD8 + T cell epitopes derived against proteins of the TS superfamily allowed the comparison of the immunodominant responses resulting from experimental infection in inbred mice following challenge with distinct parasite strains (Martin et al 2006, Tzelepis et al 2006, 2007, 2008. CD8 + T cells of a single mouse strain (C57BL/6 mice) infected with different parasite strains recognised distinct peptides as the immunodominant epitope.…”

“…Finally, the presence of a strong CD8 + T cell immune response may select variants that no longer act as a target for these protective CD8 + T cells as is the case with HCV or HIV (Tester et al 2005, Watkins 2008). This hypothesis was tested once following vaccination with TS in the presence of CpG ODN.…”

HIV-1 Tat-Based Vaccines: An Overview and Perspectives in the Field of HIV/AIDS Vaccine Development

“…[63][64][65][66][67]. These strategies based on recombinant proteins, DNA plasmids, or expression vectors have proven to be effective in controlling viremia and progression to AIDS in non-human primates [68][69][70][71][72][73][74][75]. Nevertheless, evidence indicates that the targeting of T-cell responses on immunodominant epitopes can facilitate the insurgence of viral mutants that escape the vaccineinduced immune control [76,77].…”