Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment

Ogungbamigbe, T O; Ojurongbe, Olusola; Ogunro, P S; Okanlawon, B. M.; Kolawole, SO

doi:10.1590/s0074-02762008000100012

Cited by 19 publications

(16 citation statements)

References 30 publications

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“…Chloroquine and sulphadoxine/pyrimethamine resistance is a known problem in Benin City, like in other parts of Nigeria. 2,11 This was a cross-sectional study assessing the efficacy and safety of AS+AQ. It was conducted between September 2011-2012.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and safety of Camosunate for the treatment of uncomplicated malaria in the University of Benin Teaching Hospital, Benin City, Nigeria

Uyagu

Omoigberale

Dienye

2013

Healthc Low Resour Settings

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Section: Methodsmentioning

confidence: 99%

Efficacy and safety of Camosunate for the treatment of uncomplicated malaria in the University of Benin Teaching Hospital, Benin City, Nigeria

Uyagu

Omoigberale

Dienye

2013

Healthc Low Resour Settings

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“…Unfortunately, parasite resistance to available antimalarials is spreading and has rendered treatment increasingly difficult in endemic areas. [27][28][29][30] Chloroquine was referred to as a wonder drug when it was introduced .50 years ago, and it was the cornerstone of antimalarial treatment for many years in Africa. 31 It was cheap, with very low toxicity, effective against all forms of malaria, relatively easy to manufacture, chemically stable, and readily stored and transported, even under extreme climatic conditions, 27 attributes, which none of the currently available antimalarials possess.…”

Section: Strategies For Malaria Control Eradication and Eliminationmentioning

confidence: 99%

“…[27][28][29][30] Chloroquine was referred to as a wonder drug when it was introduced .50 years ago, and it was the cornerstone of antimalarial treatment for many years in Africa. 31 It was cheap, with very low toxicity, effective against all forms of malaria, relatively easy to manufacture, chemically stable, and readily stored and transported, even under extreme climatic conditions, 27 attributes, which none of the currently available antimalarials possess. 28,32 The emergence and spread of chloroquine-resistant P. falciparum in Sub-Saharan Africa led to one of the greatest public health challenges, 27,28 prompting the use of sulfadoxine-pyrimethamine (SP) and many other alternative antimalarials.…”

Section: Strategies For Malaria Control Eradication and Eliminationmentioning

confidence: 99%

“…31 It was cheap, with very low toxicity, effective against all forms of malaria, relatively easy to manufacture, chemically stable, and readily stored and transported, even under extreme climatic conditions, 27 attributes, which none of the currently available antimalarials possess. 28,32 The emergence and spread of chloroquine-resistant P. falciparum in Sub-Saharan Africa led to one of the greatest public health challenges, 27,28 prompting the use of sulfadoxine-pyrimethamine (SP) and many other alternative antimalarials. However, resistance to SP and the other antimalarials developed rapidly a few years after their introduction, 33 with SP currently recommended only for intermittent preventive therapy in pregnancy (IPTp).…”

Section: Strategies For Malaria Control Eradication and Eliminationmentioning

confidence: 99%

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Malaria: Control, Elimination, and Eradication

Ojurongbe

Akindele²,

Adedokun³

et al. 2016

Human Parasitic Diseases

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Control, elimination, and eradication of malaria is one of the world's greatest public health challenges, especially in Sub-Saharan Africa. While there has been an impressive gain in malaria control with decreased mortality rate over the years, eradication and elimination seem to be elusive in Sub-Saharan Africa. Control and elimination of malarial parasites was previously achieved in Europe and America using insecticides and manipulation of environmental and ecological characteristics. The emergence of drug-resistant parasites coupled with environments that support the breeding of mosquito vector and the need for caution with insecticides, such as dichlorodiphenyltrichloroethane, has slowed down control efforts, making elimination and eradication an uphill task in Sub-Saharan Africa. The expectation of producing an effective vaccine has been on for .40 years, but the recent breakthrough announcement of a malaria vaccine showing some level of protection among infants and children 3-4 years post vaccination seems like an excellent starting point. The globally accepted strategy for the control of malaria rely on chemotherapy, but unfortunately the overreliance on chemotherapy without proper control of drug usage and diagnosis has encouraged the selection of drug-resistant parasites, significantly contributing to the problem. Therefore, the prospects of malaria eradication rest heavily on integrated approaches that would include chemotherapy, vector control, manipulation of environmental and ecological characteristics, and vaccination. This article reviews the current state of malaria control and elimination and the need for an multistrategic integrated approach in order to achieve malaria eradication if the challenges faced by elimination are addressed.

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“…Currently, artemetherlumefantrine (Coartem) and artesunate-amodiaquine (Larimal) are the most widely used among the ACTs currently available in Nigeria. A few years after the policy change, chloroquine and sulfadoxinepyrimethamine were still being widely used among the populace [6]. With increased efforts to raise awareness of appropriate malaria treatment, ACTs are now being widely used.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of artemisinin combination therapy for the treatment of uncomplicated falciparum malaria in Nigerian children

Ojurongbe

Lawal

Abiodun

et al. 2013

J Infect Dev Ctries

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Introduction: The development and spread of Plasmodium falciparum resistance to most commonly used antimalarials remain a major challenge in the control of malaria. Constant monitoring of drug efficacy is an important tool in establishing rational antimalarial drug policies. Methodology: A randomized comparative study was conducted at the Wesley Guild Hospital, Ilesa, Nigeria between February 2010 and September 2011 comparing the efficacy and safety of artemether-lumefantrine (Coartem) and fixed dose of artesunate plus amodiaquine (Larimal) in the treatment of uncomplicated P. falciparum malaria in children betweem 6 and 144 months of age. P. falciparum malaria parasitemia was assessed by microscopy and rapid diagnostic test. Drugs were administered according to age for three days under supervision. The primary efficacy endpoint was a day 28 PCR-corrected parasitological cure. Results: A total of 182 patients were enrolled in the two treatment groups, Coartem (n = 101) and Larimal (n = 81), and tested after 28 days. In the intention-to-treat population, Coartem (n= 101) and Larimal (n= 81) had a PCR-corrected cure rate of 98% and 100% respectively, while in the per-protocol population, Coartem (n = 89) and Larimal (n = 71) both had a PCR-corrected cure rate of 100% at day 28. Although parasite and fever clearance time was faster in the Larimal group, no significant difference was observed between the two drugs. No serious adverse effects were reported. Conclusion: Five years after being introduced in Nigeria, both Coartem and Larimal have been shown to be safe and highly effective in the treatment of uncomplicated P. falciparum malaria in children.

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Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment

Abstract: Chloroquine (CQ) resistance in

Cited by 19 publications

References 30 publications

Efficacy and safety of Camosunate for the treatment of uncomplicated malaria in the University of Benin Teaching Hospital, Benin City, Nigeria

Efficacy and safety of Camosunate for the treatment of uncomplicated malaria in the University of Benin Teaching Hospital, Benin City, Nigeria

Malaria: Control, Elimination, and Eradication

Efficacy of artemisinin combination therapy for the treatment of uncomplicated falciparum malaria in Nigerian children

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