Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity

Carneiro, Ana Lúcia Basílio; Teixeira, María Francisca Simas; Oliveira, Viviana Maria Araújo de; Fernandes, Ormezinda Celeste Cristo; Cauper, Gláucia Socorro de Barros; Pohlit, Adrian Martin

doi:10.1590/s0074-02762008000100005

Cited by 16 publications

(14 citation statements)

References 30 publications

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Section: Himatanthus Articulatus (Vahl) Woodson Is a Tree Found In Thmentioning

confidence: 99%

“…In general, many widely-used plant-derived remedies from the Amazon have never been evaluated in a laboratory or clinical setting. Such investigations generate valuable knowledge on the potential of Amazon biodiversity (Carneiro et al 2008).Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a tree found in Panama, Colombia, Peru, Bolivia, Venezuela, Guyana, Suriname, French Guiana and in the savannah regions of the state of Roraima (RR), in the northern Brazilian Amazon (Milliken 1995, Wood et al 2001, Mobot 2007 (Elizabetsky & Castilhos 1990) and are important agents in the treatment of blood parasites such as Trypanosoma cruzi and Leishmania donovani (Mesquita et al 2005). Antitumor and aphrodisiac properties have been reported for the latex derived from sucuba, which is typically diluted in water and administered orally (Van den Berg 1984).…”

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confidence: 99%

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Antibacterial and antifungal activity of extracts and exudates of the Amazonian medicinal tree Himatanthus articulatus (Vahl) Woodson (common name: sucuba)

Sequeira

Vital

Pohlit

et al. 2009

Mem. Inst. Oswaldo Cruz

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Himatanthus articulatus (Vahl) Woodson is a tree found in the northern Amazon savannahs (common name:Promoting scientific research into traditional medicine can be a means of preventing the disappearance of the cultural practices of a people and provide a simple and locally accessible therapeutic alternative to local health authorities. In recent times, greater access to industrialized pharmaceuticals has, in general, been accompanied by a decline in medicinal knowledge and the use of plant-based remedies. However, in the Amazon Region, the medicinal use of products derived from plants by local communities continues to be a significant practice. Furthermore, many local indigenous populations depend exclusively on natural products for the treatment and cure of disease (Milliken 1995). In general, many widely-used plant-derived remedies from the Amazon have never been evaluated in a laboratory or clinical setting. Such investigations generate valuable knowledge on the potential of Amazon biodiversity (Carneiro et al. 2008).Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a tree found in Panama, Colombia, Peru, Bolivia, Venezuela, Guyana, Suriname, French Guiana and in the savannah regions of the state of Roraima (RR), in the northern Brazilian Amazon (Milliken 1995, Wood et al. 2001, Mobot 2007 (Elizabetsky & Castilhos 1990) and are important agents in the treatment of blood parasites such as Trypanosoma cruzi and Leishmania donovani (Mesquita et al. 2005). Antitumor and aphrodisiac properties have been reported for the latex derived from sucuba, which is typically diluted in water and administered orally (Van den Berg 1984). According to Souza et al. (2004), plants belonging to the genus Himatanthus demonstrate a large spectrum of anti-bacterial activities. Also, sucuba is commonly sold for use as an antimicrobial agent in popular markets in RR. No previous investigation of the antibacterial or antifungal activity of H. articulatus is available in the literature, although antimicrobial activity has been reported for other Himatanthus spp. (Morel et al. 2006).It is known that microorganisms frequently become resistant to conventional antimicrobial agents, so the utilization of natural antimicrobial agents could represent a low-cost alternative therapy for traditional communities from the Brazilian Amazon. Also, chemical studies of antimicrobial plant extracts could reveal new substances with potential usefulness as antimicrobial drugs or as models for the development of new drugs. Thus, the aim of the present work was to evaluate the antibacterial and antifungal potential of leaf, bark and branch wood extracts and the latex of H. articulatus against the growth of several human pathogenic bacterial and fungal strains.According to statistical data available from the Laboratório Central de Roraima (LACEN), which is located in Boa Vista, the capital of RR, for the period of 2004-2007, Escherichia coli was responsible for 80% of the clinical cases of genital and urinary infections, Staphylococcus aureus was resp...

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Section: Himatanthus Articulatus (Vahl) Woodson Is a Tree Found In Thmentioning

confidence: 99%

mentioning

confidence: 99%

Antibacterial and antifungal activity of extracts and exudates of the Amazonian medicinal tree Himatanthus articulatus (Vahl) Woodson (common name: sucuba)

Sequeira

Vital

Pohlit

et al. 2009

Mem. Inst. Oswaldo Cruz

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“…calycina (Annonaceae) is a promising antimicrobial plant (Carneiro et al, 2008) which needs further study to reveal the identity of several antimicrobial substances present in its extracts according autobiography performed on thinlayer chromatographic plates.…”

Section: Resultsmentioning

confidence: 99%

“…In vitro screening of amazonian plants for hemolytic activity and inhibition of platelet aggregation in human blood strains of bacteria and fungi associated with human diseases (Carneiro et al, 2008). The present study therefore represents a further expansion on the available knowledge of the in vitro biological activity of these non-medicinal species from the western Amazon forest.…”

Section: Introductionmentioning

confidence: 84%

In vitro screening of Amazonian plants for hemolytic activity and inhibition of platelet aggregation in human blood

et al. 2009

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In the present study, different aerial parts from twelve Amazonian plant species found in the national Institute for Amazon Research's (InpA's) Adolpho Ducke Forest Reserve (in Manaus, Amazonas, Brazil) were collected. Separate portions of dried, ground plant materials were extracted with water (by infusion), methanol and chloroform (by continuous liquidsolid extraction) and solvents were removed first by rotary evaporation, and finally by freeze-drying which yielded a total of seventy-one freeze-dried extracts for evaluation. These extracts were evaluated initially at concentrations of 500 and 100 µg/ mL for in vitro hemolytic activity and in vitro inhibition of platelet aggregation in human blood, respectively. Sixteen extracts (23 % of all extracts tested, 42 % of all plant species), representing the following plants: Chaunochiton kappleri (Olacaceae), Diclinanona calycina (Annonaceae), Paypayrola grandiflora (Violaceae), Pleurisanthes parviflora (Icacinaceae), Sarcaulus brasiliensis (Sapotaceae), exhibited significant inhibitory activity towards human platelet aggregation. A group of extracts with antiplatelet aggregation activity having no in vitro hemolytic activity has therefore been identified. Three extracts (4 %), all derived from Elaeoluma nuda (Sapotaceae), exhibited hemolytic activity. none of the plant species in this study has known use in traditional medicine. So, these data serve as a baseline or minimum of antiplatelet and hemolytic activities (and potential usefulness) of non-medicinal plants from the Amazon forest. Finally, in general, these are the first data on hemolytic and inhibitory activity on platelet aggregation for the genera which these plant species represent. Testes in vitro de plantas Amazônicas para atividade hemolítica e inibição da agregação plaquetária em sangue humano RESUMO no presente estudo, partes aéreas obtidas de doze (12) espécies vegetais da Amazônia encontradas na Reserva Florestal Adolpho Ducke (localizada na cidade de Manaus, Estado do Amazonas, Brasil) do Instituto nacional de pesquisas da Amazônia foram coletadas, secadas e moídas. porções dos materiais vegetais em pó foram extraídas com água (por infusão), metanol e clorofórmio (por extração líquido-sólido contínua) e os solventes foram removidos por evaporação rotatória e finalmente liofilização, forneceram um total de setenta e one (71) extratos liofilizados. Esses extratos foram avaliados inicialmente para atividade hemolítica in vitro e atividade inibitória da agregação plaquetária em sangue humano in vitro em concentrações de 500 e 100 µg/ mL, respectivamente. Dezesseis (16) extratos (23 % dos extratos testados, 42 % das espécies vegetais) representando as seguintes plantas, apresentaram inibição significativa frente a agregação de plaquetas humanas in vitro: Chaunochiton kappleri (Olacaceae), Diclinanona calycina (Annonaceae), Paypayrola grandiflora (Violaceae), Pleurisanthes parviflora (Icacinaceae), Sarcaulus brasiliensis (Sapotaceae). Como principal resultado, um grupo de extratos apresentando ...

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“…Plant extracts showing antimicrobial activity against certain pathogens have been reported by various researchers 25,26,27,28,29,30 .…”

Section: In -Vitromentioning

confidence: 97%

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2016

IJPSR

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Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity

Cited by 16 publications

References 30 publications

Antibacterial and antifungal activity of extracts and exudates of the Amazonian medicinal tree Himatanthus articulatus (Vahl) Woodson (common name: sucuba)

Antibacterial and antifungal activity of extracts and exudates of the Amazonian medicinal tree Himatanthus articulatus (Vahl) Woodson (common name: sucuba)

In vitro screening of Amazonian plants for hemolytic activity and inhibition of platelet aggregation in human blood

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