Chagas disease: what is known and what is needed - A background article

Coura, José Rodrigues

doi:10.1590/s0074-02762007000900018

Cited by 247 publications

(162 citation statements)

References 37 publications

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“…T. cruzi parasitemia in patients with chronic ChD varies considerably in different endemic regions. Moreover, clinical forms of the disease, morbidity, and mortality can also vary from one endemic area to another, and the intensity of infection and the immune response of patients also differs 19 . ChD progression may result from changes in the patient's immune response during the course of T. cruzi infection 42 .…”

Section: Discussionmentioning

confidence: 99%

“…Based on different molecular markers, the Second Satellite Meeting recommended that T. cruzi should be classified into six discrete typing units (DTUs; T. cruzi I-VI) 18 . The biological characteristics of T. cruzi strains and clones, and particularly their tissue tropism, may play important roles as determinants of ChD and its clinical forms 19 . The diagnosis of T. cruzi infection should be directed based on the phase of infection.…”

Section: Introductionmentioning

confidence: 99%

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Combined parasitological and molecular-based diagnostic tools improve the detection of Trypanosoma cruzi in single peripheral blood samples from patients with Chagas disease

Volpato

Sousa

D’Ávila

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction:In order to detect Trypanosoma cruzi and determine the genetic profiles of the parasite during the chronic phase of Chagas disease (ChD), parasitological and molecular diagnostic methods were used to assess the blood of 91 patients without specific prior treatment. Methods: Blood samples were collected from 68 patients with cardiac ChD and 23 patients with an indeterminate form of ChD, followed by evaluation using blood culture and polymerase chain reaction. T. cruzi isolates were genotyped using three different genetic markers. Results: Blood culture was positive in 54.9% of all patients, among which 60.3% had the cardiac form of ChD, and 39.1% the indeterminate form of ChD. There were no significant differences in blood culture positivity among patients with cardiac and indeterminate forms. Additionally, patient age and clinical forms did not influence blood culture results. Polymerase chain reaction (PCR) was positive in 98.9% of patients, although comparisons between blood culture and PCR results showed that the two techniques did not agree. Forty-two T. cruzi stocks were isolated, and TcII was detected in 95.2% of isolates. Additionally, one isolate corresponded to TcIII or TcIV, and another corresponded to TcV or TcVI. Conclusions: Blood culture and PCR were both effective for identifying T. cruzi using a single blood sample, and their association did not improve parasite detection. However, we were not able to establish an association between the clinical form of ChD and the genetic profile of the parasite.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combined parasitological and molecular-based diagnostic tools improve the detection of Trypanosoma cruzi in single peripheral blood samples from patients with Chagas disease

Volpato

Sousa

D’Ávila

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…Chagas disease, caused by the hemoflagellate protozoan Trypanosoma cruzi, afflicts 15-16 million people in South America with 75-90 million people exposed to infection (Coura 2007). Approximately 30% of patients develop a chronic disease typically characterized by myocarditis associated with prominent fibrotic scarring and organ dysfunction (Teixeira et al 2006, Coura 2007.…”

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confidence: 99%

“…Approximately 30% of patients develop a chronic disease typically characterized by myocarditis associated with prominent fibrotic scarring and organ dysfunction (Teixeira et al 2006, Coura 2007. Although heart inflammatory cells contribute to control parasite growth, they are also involved in perpetuating heart disease (Freitas et al 2005).…”

mentioning

confidence: 99%

TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-α blockade

Kroll-Palhares

Silvério

Silva

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…Furthermore, recognition of the epidemiological importance of sylvatic and semi-domiciliated vectors indicates the requirement for permanent surveillance in order to avoid the resurgence of acute Chagas disease in our territory (Coura 2007, Guhl et al 2009, Lazzari & Lorenzo 2009). …”

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confidence: 99%

Chagas disease centennial anniversary celebration: historical overview and prospective proposals aiming to maintain vector control and improve patient prognosis - a permanent challenge

Lannes-Vieira¹,

Soeiro²,

Corrêa-Oliveira³

et al. 2009

Mem. Inst. Oswaldo Cruz

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EditorialChagas disease centennial anniversary celebration: historical overview and prospective proposals aiming to maintain vector control and improve patient prognosis -a permanent challengeThe organisation of the "International Symposium on the Centennial of the Discovery of Chagas Disease" (Rio de Janeiro, Brazil) is among the actions initiated by the Oswaldo Cruz Foundation to celebrate the centenary of the discovery of American trypanosomiasis by Carlos Chagas, in 1909. This Symposium comes at a time when discussions on new approaches for the control of this devastating disease are needed and it creates a unique opportunity for up-to-date presentations and debates from an assembly of eminent researchers from different countries. More than 650 participants, presenting about 300 posters, as well as 52 lectures and conferences, are expected at this meeting. This congregation of leading researchers gives us an historical opportunity to revisit the unique achievement of Carlos Chagas when he discovered a new nosology, as well as its vector and causative agent, the haemoflagellate protozoan Trypanosoma cruzi. He also described the entire life cycle and the pathology caused by this infectious agent. Furthermore, the question-based lectures and conferences create the propitious scenario for discussion of the plethora of information on the disease and for the reflection on proposals that contribute significantly to the advancement of knowledge in the field of Chagas disease, keeping in mind the importance of vector control maintenance and overall patient care, including early diagnosis, adequate follow up and therapy, aiming to improve both prognosis and quality of life.Here, we wish to thank the participants for their efforts and our colleagues for taking part in the discussions and presenting their findings during the lectures and round tables. Further, we thank the Scientific Committee, for the great suggestions that helped us to build this meeting, as well as all the referees that acted promptly to revise the manuscripts published herein, and the abstracts presented in the poster format during the Symposium. Furthermore, we are also in debt to the Oswaldo Cruz Foundation, ABRASCO, Fiotec, FAPERJ, CNPq and CAPES, for their support.

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Chagas disease: what is known and what is needed - A background article

Cited by 247 publications

References 37 publications

Combined parasitological and molecular-based diagnostic tools improve the detection of Trypanosoma cruzi in single peripheral blood samples from patients with Chagas disease

Combined parasitological and molecular-based diagnostic tools improve the detection of Trypanosoma cruzi in single peripheral blood samples from patients with Chagas disease

TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-α blockade

Chagas disease centennial anniversary celebration: historical overview and prospective proposals aiming to maintain vector control and improve patient prognosis - a permanent challenge

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