Polymorphism in the promoter region of the mannose-binding lectin gene among human T-cell lymphotropic virus infected subjects

Alves, Anna; Hermes, Renata Bezerra; Tamegão-Lopes, Bruna Pedroso; Machado, Luiz Fernando Almeida; Azevedo, Vânia Nakauth; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo; Lemos, José Alexandre Rodrigues de; Vallinoto, Antônio Carlos Rosário

doi:10.1590/s0074-02762007000800015

Cited by 9 publications

(9 citation statements)

References 17 publications

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“…The search for host immunogenetic markers, possibly associated with HTLV-1 infection and progression to disease was pursued by our research group in the Amazon region of Brazil and other groups elsewhere ( Nishimura et al, 1991 ; Jeffery et al, 2000 ; Pontes et al, 2005 ; Alves et al, 2007 ; Vallinoto et al, 2012 , 2015 ; de Sá et al, 2016 ; Rosado et al, 2017 ). Polymorphisms rs1800450 (allele B, codon 54) and rs1800682 (-670A/G) located in MBL2 and FAS genes, respectively, were strongly associated with HTLV-1 infection.…”

Section: Introductionmentioning

confidence: 99%

Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report

et al. 2018

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Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with ATL and inflammatory diseases but remains a neglected health problem. HTLV-1 associated diseases were originally described as sporadic entities, but family aggregations have been reported. Viral, genetic, immunological and behavioral factors were used to explain family clusters, but until now a clear explanation remains uncertain. In the present study we report, for the first time, a family cluster of diseased persons presenting the infection across three generations associated with FAS -670A/G polymorphism.

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Section: Introductionmentioning

confidence: 99%

Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report

et al. 2018

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“…Three mutations of the wild allele MBL*A have been identified in the structural region of the molecule (codons 52, 54 and 57) with three allelic variants named MBL*D, MBL*B and MBL*C, respectively 4 . These variants have been associated with MBL serum deficiency and, consequently, variations in the susceptibility or resistance to infection in carriers by a number of pathogens [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Characterization of mannose-binding lectin plasma levels and genetic polymorphisms in HIV-1-infected individuals

Vallinoto

Freitas

Guirelli

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and serum levels with infection by HIV-1. Methods: Blood samples (5mL) were collected from 97 HIV-1-infected individuals resident in Belém, State of Pará, Brazil, who attended the Special Outpatient Unit for Infections and Parasitic Diseases (URE-DIPE). CD4 + T-lymphocyte count and plasma viral load were quantified. A 349bp fragment of exon 1 of the MBL was amplified via PCR, using genomic DNA extracted from controls and HIV-1-infected individuals, following established protocols. MBL plasma levels of the patients were quantified using an enzyme immunoassay kit. Results: Two alleles were observed: MBL*O, with a frequency of 26.3% in HIV-1-infected individuals; and the wild allele MBL*A (73.7%). Similar frequencies were observed in the control group (p > 0.05). Genotype frequencies were distributed according to the Hardy-Weinberg equilibrium in both groups. Mean MBL plasma levels varied by genotype, with statistically significant differences between the AA and AO (p < 0.0001), and AA and OO (p < 0.001) genotypes, but not AO and OO (p = 0.17). Additionally, CD4+ T-lymphocytes and plasma viral load levels did not differ significantly by genotype (p > 0.05). Conclusions: The results of this study do not support the hypothesis that MBL gene polymorphism or low plasma MBL concentrations might have a direct influence on HIV-1 infection, although a broader study involving a large number of patients is needed.

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“…The occurrence of these variants has been associated with MBL serum deficiency and, consequently, variations in susceptibility/ resistance to infection by various pathogens [7,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Mannose-binding lectin gene polymorphisms are not associated with susceptibility to hepatitis C virus infection in the Brazilian Amazon region

Vallinoto¹,

Silva²,

Hermes³

et al. 2009

Human Immunology

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Polymorphism in the promoter region of the mannose-binding lectin gene among human T-cell lymphotropic virus infected subjects

Abstract: The present study investigated the frequency of the mutations at positions -550 and -221

Cited by 9 publications

References 17 publications

Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report

Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report

Characterization of mannose-binding lectin plasma levels and genetic polymorphisms in HIV-1-infected individuals

Mannose-binding lectin gene polymorphisms are not associated with susceptibility to hepatitis C virus infection in the Brazilian Amazon region

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