Population structure of the malaria vector Anopheles darlingi in Rondônia, Brazilian Amazon, based on mitochondrial DNA

Angella, Aline; Gil, Luiz Herman Soares; Silva, Luis Hildebrando Pereira da; Ribolla, Paulo Eduardo Martins

doi:10.1590/s0074-02762007000800010

Cited by 15 publications

(13 citation statements)

References 28 publications

(19 reference statements)

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“…darlingi phylogenetic network represents various feasible topologies (areas full of boxes), indicating the relationships among specimens from different sites from Central and South America, the result suggests that a more intense sampling should be conducted to gain a clearer picture of the general population structure and evolutionary history of this species through its distribution range. 63 Haplotype M found by Mirabello and Conn 19 in Nechi, a locality in Antioquia, was identical to haplotype B found widely dispersed in the present work ( Figures 3 and 5 15,67 have shown that An. darlingi populations were highly homogeneous, and there were no clear correlations among genetic and geographic distance.…”

supporting

confidence: 83%

“…darlingi populations were highly homogeneous, and there were no clear correlations among genetic and geographic distance. 15 As in previous reports, 20,28,33 the MS markers used in the present work have not been physically mapped to An. darlingi chromosomes.…”

mentioning

confidence: 76%

“…13 The prediction of the dispersal of genes important for insecticide resistance or refractoriness to the parasite 14 could improve vector control strategies. 15 Anopheles darlingi has been incriminated as a competent vector of all human Plasmodium species present in the Americas, P. falciparum Welch, P. vivax Grassi and Felleti, variants VK210 and VK247, and P. malariae Laveran. 10,[16][17][18] The importance of…”

Section: Introductionmentioning

confidence: 99%

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Microgeographic Genetic Variation of the Malaria Vector Anopheles darlingi Root (Diptera: Culicidae) from Córdoba and Antioquia, Colombia

Gutiérrez¹,

Gómez²,

González³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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Abstract. Anopheles darlingi is an important vector of Plasmodium spp. in several malaria-endemic regions of Colombia. This study was conducted to test genetic variation of An. darlingi at a microgeographic scale (approximately 100 km) from localities in Córdoba and Antioquia states, in western Colombia, to better understand the potential contribution of population genetics to local malaria control programs. Microsatellite loci: nuclear white and cytochrome oxidase subunit I ( COI ) gene sequences were analyzed. The northern white gene lineage was exclusively distributed in Córdoba and Antioquia and shared COI haplotypes were highly represented in mosquitoes from both states. COI analyses showed these An. darlingi are genetically closer to Central American populations than southern South American populations. Overall microsatellites and COI analysis showed low to moderate genetic differentiation among populations in northwestern Colombia. Given the existence of high gene flow between An. darlingi populations of Córdoba and Antioquia, integrated vector control strategies could be developed in this region of Colombia.

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confidence: 83%

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confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Microgeographic Genetic Variation of the Malaria Vector Anopheles darlingi Root (Diptera: Culicidae) from Córdoba and Antioquia, Colombia

Gutiérrez¹,

Gómez²,

González³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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“…The size and structure of cytochrome oxidase subunit 1 (COI) gene has been well conserved in the animal groups analysed so far, a feature which makes it especially suitable for evolutionary studies (Lunt et al 1996). In recent years, comparison of mitochondrial DNA sequences has been used for population genetics and phylogenetic studies in several dipterans of medical, veterinary and economic importance (Hall et al 2001;Zehner et al 2004;Cummings and Krafsur 2005;Segura et al 2006;Angella et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA sequence-based phylogenetic relationship among flesh flies of the genus Sarcophaga (Sarcophagidae: Diptera)

Bajpai

Tewari

2010

J Genet

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The phylogenetic relationships among flesh flies of the family Sarcophagidae has been based mainly on the morphology of male genitalia. However, the male genitalic character-based relationships are far from satisfactory. Therefore, in the present study mitochondrial DNA has been used as marker to unravel genetic relatedness and to construct phylogeny among five sympatric species of the genus Sarcophaga. Two mitochondrial genes viz., cytochrome oxidase subunit 1 (COI) and NAD dehydrogenase subunit 5 (ND5) were sequenced and genetic distance values were calculated on the basis of sequence differences in both the mitochondrial genes. The data revealed very few genetic difference among the five species for the COI and ND5 gene sequences.

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“…Charlwood [8] found chromosomal, morphological and behavioural differences between A. darlingi from central Amazon and further north (Venezuela and Guyana). However, several isozyme and DNA-based studies reported levels of genetic differentiation consistent with a monotypic species throughout the species' range [9-11]. Although mtDNA history revealed some genetic divergence between South and Central American populations [12-14], complete mtDNA genomes of A. darlingi did not provide support for speciation within the taxon [6].…”

Section: Introductionmentioning

confidence: 99%

Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi

Angella

Salgueiro

Gil³

et al. 2014

Malar J

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BackgroundAnopheles darlingi is the main malaria mosquito vector in the Amazonia region. In spite of being considered a riverine, forest-dwelling species, this mosquito is becoming more abundant in peri-urban areas, increasing malaria risk. This has been associated with human-driven environmental changes such as deforestation.MethodsMicrosatellites were used to characterize A. darlingi from seven localities along the Madeira River, Rondônia (Brazil), collected in the early and late periods of the rainy season.ResultsTwo genetically distinct subpopulations were detected: one (subpopulation A) was associated with the late rainfall period and seems to be ecologically closer to the typical forest A. darlingi; the other (subpopulation B) was associated with the early rainfall period and is probably more adapted to drier conditions by exploiting permanent anthropogenic breeding sites. Results suggest also a pattern of asymmetric introgression, with more subpopulation A alleles introgressed into subpopulation B. Both subpopulations (and admixed mosquitoes) presented similar malaria infection rates, highlighting the potential for perennial malaria transmission in the region.ConclusionsThe co-occurrence of two genetically distinct subpopulations of A. darlingi adapted to different periods of rainfall may promote a more perennial transmission of malaria throughout the year. These findings, in a context of strong environmental impact due to deforestation and dam construction, have serious implications for malaria epidemiology and control in the Amazonian region.

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Population structure of the malaria vector Anopheles darlingi in Rondônia, Brazilian Amazon, based on mitochondrial DNA

Cited by 15 publications

References 28 publications

Microgeographic Genetic Variation of the Malaria Vector Anopheles darlingi Root (Diptera: Culicidae) from Córdoba and Antioquia, Colombia

Microgeographic Genetic Variation of the Malaria Vector Anopheles darlingi Root (Diptera: Culicidae) from Córdoba and Antioquia, Colombia

Mitochondrial DNA sequence-based phylogenetic relationship among flesh flies of the genus Sarcophaga (Sarcophagidae: Diptera)

Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi

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