Antigenic and genomic characterization of adenovirus associated to respiratory infections in children living in Northeast Brazil

Moura, Fernanda Edna Araújo; Mesquita, Jacó Ricarte Lima de; Portes, Silvana Augusta Rodrigues; Ramos, Eduardo Antônio Gonçalves; Siqueira, Marilda Mendonça

doi:10.1590/s0074-02762007000800008

Cited by 18 publications

(16 citation statements)

References 42 publications

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“…Subgroup E was only seen in Peru after August 2008 and represents 3% of the total HAdvs found. This distribution agrees with recently published studies 4,13,14 but differs from previous studies showing that the predominant species circulating in Latin America was B 7,13,15,16 …”

Section: Resultssupporting

confidence: 90%

Molecular characterization of adenovirus circulating in Central and South America during the 2006–2008 period

Garcia

Sovero

Laguna-Torres

et al. 2009

Influenza Resp Viruses

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Background Human Adenoviruses are recognized pathogens, causing a broad spectrum of diseases. Serotype identification is critical for epidemiological surveillance, detection of new strains and understanding of HAdvs pathogenesis. Little data is available about HAdvs subtypes in Latin America. Methods In this study, we have molecularly characterized 213 adenoviruses collected from ILI presenting patients, during 2006‐08, in Central and South America. Results Our results indicate that 161(76%) adenoviruses belong to subgroup C, 45 (21%) to subgroup B and 7 (3%) to subtype E4.

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Section: Resultssupporting

confidence: 90%

Molecular characterization of adenovirus circulating in Central and South America during the 2006–2008 period

Garcia

Sovero

Laguna-Torres

et al. 2009

Influenza Resp Viruses

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“…In Colombia, 2.6% (47/1743) of respiratory samples from children under 5 with ILI or SARI contained HAdv [38]. In Brazil, samples collected from pediatric patients with ILI or SARI (<5 years old) demonstrated a broad range of proportions containing HAdv: 6.8% (23/336) in São Paulo [39], 6.0% (52/862) in Rio Grande do Sul [40], and 2.3% (11/482) in Salvador, Bahia [41]. Among samples only from children with SARI, proportions of HAdv ranged between: 2.8% (28/1002) from 1984 to 1987 [42] and 1.9% (916/48544) from 1999 to 2010 [43] in Argentina; 9.3% (457/4927) from 1989 to 2001 in Chile [44], and 7.0% (9/128) from 1996 to 1997 [45] and 6.2% (2/32) from 2006 to 2007 [46] in Cuba.…”

Section: Discussionmentioning

confidence: 99%

“…In all four regions (northern coast, central coast, southern highlands, and jungle) subgroup C predominated, subgroup B was the second most common, and subgroup E was the least common (except for the central coast where B and E were identified in the same number). Likewise, the bordering country of Brazil [41], [56], as well as the non-bordering Latin American countries of Mexico [57] and Cuba [45], also observed a predominance of subgroup C. On the other hand, two other countries bordering Peru, Colombia [38], [58] and Argentina [43], noted a predominance of subgroup B.…”

Section: Discussionmentioning

confidence: 99%

Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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BackgroundCurrently, there is a paucity of data regarding human adenovirus (HAdv) circulation in Andean regions of South America. To address this shortcoming, we report the clinical, phylogenetic, and epidemiologic characteristics of HAdv respiratory tract infection from a large sentinel surveillance study conducted among adults and children in Peru.Methods/Principal FindingsOropharyngeal swabs were collected from participants visiting any of 38 participating health centers, and viral pathogens were identified by immunofluorescence assay in cell culture. In addition, molecular characterization was performed on 226 randomly selected HAdv samples. Between 2000 and 2010, a total of 26,375 participants with influenza-like illness (ILI) or severe acute respiratory infection (SARI) were enrolled in the study. HAdv infection was identified in 2.5% of cases and represented 6.2% of all viral pathogens. Co-infection with a heterologous virus was found in 15.5% of HAdv cases. HAdv infection was largely confined to children under the age of 15, representing 88.6% of HAdv cases identified. No clinical characteristics were found to significantly distinguish HAdv infection from other respiratory viruses. Geographically, HAdv infections were more common in sites from the arid coastal regions than in the jungle or highland regions. Co-circulation of subgroups B and C was observed each year between 2006 and 2010, but no clear seasonal patterns of transmission were detected.Conclusions/SignificanceHAdv accounted for a significant fraction of those presenting with ILI and SARI in Peru and tended to affect the younger population disproportionately. Longitudinal studies will help better characterize the clinical course of patients with HAdv in Peru, as well as determine the role of co-infections in the evolution of illness.

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“…10,13,20 Only a few studies were conducted to investigate the prevalence and seasonal patterns of different viral infections among children with an episode of LRTI seen at hospitals from Northeastern Brazil, where the winter is warm and wet. 14,16,[21][22][23][24] Such studies were typically conducted in only 1 major city in the region and have not allowed for concurrent assessments within different areas of the Northeastern region of Brazil. Moreover, they have used different eligibility criteria and methods for viral identification.…”

Section: Introductionmentioning

confidence: 99%

Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil

et al. 2016

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Few studies, each limited to a single major city, have investigated the prevalence and seasonal patterns of different viruses among children with low respiratory tract infections (LRTI) in Northeastern Brazil. The aim of this study was to determine the frequency of respiratory syncytial virus (RSV) and of 7 other viruses in children for LRTI in 4 capitals from this region, and investigate their association with several risk factors, including meteorological data.From April 2012 to March 2013, 507 children, aged up to 24 months and hospitalized with LRTI in one of the participating centers at Aracajú, Salvador, Recife, and Maceió, had a sample of nasopharyngeal aspirate collected and analyzed for the following viruses by reverse-transcription polymerase chain reaction followed by hybridization on low-density microarrays: RSV, influenza, parainfluenza, adenovirus, rhinovirus, metapneumovirus, bocavirus, and coronavirus.The result was positive in 66.5% of cases, RSV was the most common virus (40.2%). Except for rhinovirus (17%), all other virus had frequency rates lower than 6%. Viral coinfections were detected in 13.8% of samples. Possible related risk factors for RSV infection were low age upon entry, attendance of daycare, low gestational age, and low educational level of the father. The relative frequency of viral infections was associated with increasing temperature and decreasing humidity separately, but the results also suggested both associated with increased frequency of RSV. Some of these findings differ from those reported for other regions in Brazil and may be used to guide policies that address LRTI.

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Antigenic and genomic characterization of adenovirus associated to respiratory infections in children living in Northeast Brazil

Cited by 18 publications

References 42 publications

Molecular characterization of adenovirus circulating in Central and South America during the 2006–2008 period

Molecular characterization of adenovirus circulating in Central and South America during the 2006–2008 period

Adenovirus Respiratory Tract Infections in Peru

Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil

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