Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure

Lenzi, Henrique Leonel; Romanha, W. de S; Santos, Rita Maria Zorzenon dos; Rosas, Alexandre; Mota, Eduardo; Manso, Pedro Paulo de Abreu; Caputo, Luzia Fátima Gonçalves; Pelajo-Machado, Marcelo

doi:10.1590/s0074-02762006000900034

Cited by 31 publications

(53 citation statements)

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“…Inflammatory granuloma is the initiation factor in the development of schistosome-induced fibrosis (Andrade, 2009;Lenzi et al, 2006). NF-kB has a central function in liver homeostasis, pathophysiology and regulation of the inflammation-fibrosis-cancer axis (Shen et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni

Chen

Hsu

et al. 2015

Acta Tropica

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Section: Discussionmentioning

confidence: 99%

Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni

Chen

Hsu

et al. 2015

Acta Tropica

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“…This process leads to inflammation, tissue eosinophilia, collagen deposition, fibrous expansion of the portal spaces and intra-hepatic portal-vein obstruction (Abath et al 2006). Granuloma formation has been described as a two-stage process with a pre-granulomatous stage, characterised by a disorganised aggregation of cells, and a granulomatous stage, during which the cells become organised (Lenzi et al 1998(Lenzi et al , 2006.…”

Section: Table IVmentioning

confidence: 99%

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Corrêa

Lisboa

Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Schistosomiasis is one of the most important causes of liver fibrosis, which is characterized by egg deposition, granulomatous inflammatory reaction and then subsequent hepatic fibrosis formation 7, 8 . Many researchers have demonstrated the anti-fibrotic effect of schistosoma eggs and soluble egg antigens (SEA).…”

Section: Introductionmentioning

confidence: 99%

Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway

Chen

Zhu

et al. 2017

Sci Rep

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Schistosomiasis is characterized by egg deposition, granulomatous inflammatory reaction and then subsequent hepatic fibrosis formation. Activated HSCs are regarded as the main effector cells in the progression of liver fibrosis and induction of senescence in hepatic stellate cells (HSCs) is vital to the reversion of hepatic fibrosis. Our previous work has showed that S. japonicum egg antigen p40 (Sjp40) could promote HSCs senescence via a STAT3/p53/p21 mechanism. In this paper, the major aim was to explore whether there are other signaling pathways in the process of Sjp40-induced HSCs aging and the underlying effect of SKP2/P27 signal pathway in this procedure. We observed the Sjp40-induced decrease of α-SMA and the senescence of LX-2 cells, and Sjp40 could upregulate P27 and downregulate the protein level of SKP2. The senescence induced by Sjp40 might be reversed in LX-2 cells that treated with P27-specific siRNA or with SKP2-special over-expression plasmid. In addition, we also demonstrated that the decreased expression of P-Rb and α-SMA induced by Sjp40 were partly restored by SKP2-overexpression. These data suggest that Sjp40 might inhibit HSCs activation by promoting cellular senescence via SKP2/P27 signaling pathway, which put forward novel mechanism in the treatment of liver fibrosis.

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Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure

Abstract: This paper centers on some whole-istic organizational and functional aspects of hepatic

Cited by 31 publications

References 34 publications

Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni

Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway

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