Differential lectin labelling of circulating hemocytes from Biomphalaria glabrata and Biomphalaria tenagophila resistant or susceptible to Schistosoma mansoni infection

Martins-Souza, Raquel Lopes; Pereira, Cíntia Aparecida de Jesus; Filho, Olindo Assis Martins; Coelho, P. M. Z.; Corrêa, Angelita Duarte; Negrão-Corrêa, Déborah

doi:10.1590/s0074-02762006000900029

Cited by 29 publications

(25 citation statements)

References 32 publications

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“…It should be remembered that Martins-Souza et al (2006) detected different lectins binding to the amoebocytes, with strong indications of a correlation with the susceptibility or resistance of the snails to S. mansoni. Does the biochemistry of the production of melanin by the melanocytes in the melanic variant of B. glabrata interfere in the snails' defense mechanisms?…”

Section: Discussionmentioning

confidence: 90%

“…The presence of degenerate sporocysts surround by a slight amoebocitary reaction shortly after infection (30 minutes, and 2 hours) might lead to the conclusion that soluble factors may be involved. Evidence of the action of the amoebocytes and the participation of different lectins in binding the larvae of the trematode with the amoebocytes (Martins-Souza et al, 2006) can be tested by the technique of cultures of the amoebocyte producing organ (APO) as first described by .…”

Section: Discussionmentioning

confidence: 99%

“…Tripp (1974) and Abdul Salam and Michelson (1980) observed that the ability of granulocyte to stick to glass and spread out depends on factors existing in the plasma. Martins-Souza et al (2006) suggest that the binding of different lectins to the amoebocytes may have some correlation with the susceptibility or resistance to the parasite.…”

Section: Introductionmentioning

confidence: 99%

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Behaviour of albino and melanic variants of Biomphalaria glabrata Say, 1818 (Mollusca: Planorbidae) following infection by Schistosoma mansoni Sambon, 1907

Allegretti

et al. 2009

Braz. J. Biol.

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The behaviour of the albino and melanic variants of Biomphalaria glabrata of Belo Horizonte (MG. Brazil) was studied comparatively, in terms of their respective susceptibilities to infection by Schistosoma mansoni of the same origin, through observation of the elimination of cercariae for a three-month period and the calculation of mortality and infection rates, in control and in infected snails. The number of amoebocytes, granulocytes and hyalinocytes in the circulating hemolymph during different periods of infection was analyzed. The evolution of the infection in the tissues was observed by means of histological cross-sections. The melanic variant showed greater susceptibility to infection and a higher mortality rate. The albino variant showed a higher number of circulating amoebocytes, both granulocytes and hyalinocytes. A higher number of degenerated sporocysts were seen in the histological cross-sections of the albino variant. The results suggest that the melanic variant of B. glabrata was more susceptible to infection by S. mansoni than was the albino variant.Keywords: Biomphalaria glabrata, amoebocytes, Schistosoma mansoni, sporocysts. Comportamento de Biomphalaria glabrata variantes albina e melânica frente à infecção pelo Schistosoma mansoni ResumoFoi estudado comparativamente o comportamento das variantes albina e melânica de Biomphalaria glabrata de Belo Horizonte (MG. Brasil), em relação à susceptibilidade à infecção pelo Schistosoma mansoni de mesma origem, através da observação da eliminação de cercárias por um período de três meses e a verificação das taxas de mortalidade e infecção nos moluscos controles e infectados. Analisou-se também, o número de amebócitos granulócitos e hialinócitos na hemolinfa circulante em diferentes períodos de infecção. A evolução da infecção nos tecidos foi observada através de cortes histológicos. A variante melânica apresentou maior susceptibilidade à infecção e maior taxa de mortalidade. A variante albina apresentou maior número de amebócitos circulantes, tanto granulócitos quanto hialinócitos. Nos cortes histológicos foi verificado maior número de esporocistos degenerados na variedade albina. Por estes resultados sugere-se que nas populações estudadas a variante melânica de B. glabrata, foi mais susceptível à infecção pelo S. mansoni.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Behaviour of albino and melanic variants of Biomphalaria glabrata Say, 1818 (Mollusca: Planorbidae) following infection by Schistosoma mansoni Sambon, 1907

Allegretti

et al. 2009

Braz. J. Biol.

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“…The carbohydrates of glycoproteins and glycolipids represent the major chemical components of the schistosome intramollusc stage (Zelck & Becker 1990, Uchikawa & Loker 1991. These carbohydrates can be recognised by lectins present in the snail's IDS and it has been demonstrated that lectins play an important role in the parasite/mollusc interaction (Uchikawa & Loker 1991, Johnston & Yoshino 1996, Martins-Souza et al 2006. Lectins (carbohydrate-binding proteins) are also important receptors for the non-self recognition capabilities of snails and others invertebrates (Renwrantz 1986).…”

Section: Discussionmentioning

confidence: 99%

Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite

Mattos

Martins-Souza

Kusel

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…E-mail: kah201017@yahoo.com. primary effectors of the snail defense system and its resistance lies in the ability of circulating hemocytes to recognize and bind the parasite surface and then undergo a cytotoxic activation, resulting in the effective killing of the parasite (Matricon-Gondran and Letocart, 1999;Bahgat et al, 2002;Martins-Souza et al, 2006). Some gene combinations allow the parasite to develop and proliferate because the snail fails to recognize it as foreign.…”

Section: Introductionmentioning

confidence: 99%

Histopathological study on susceptible and resistant Bulinus truncatus snails to infection with Schistosoma haematobium

Saad¹,

Gawish²,

El-Einin³

et al. 2013

Afr. J. Pharm. Pharmacol.

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In this study, the distribution pattern of Schistosoma haematobium miracidia level to host susceptibility/resistance and the basic cellular responses during the parasite development was investigated. Several snail stocks showed a wide spectrum of host reaction to the parasite. A vigorous "resistant-type" cellular response to invading miracidia was seen in the histological sections of non-susceptible snails. In this respect, they were classified as "resistant snails". Bulinus truncatus infected with S. haematobium exhibited a wide range of histopathological change, suggesting the presence of endogenous factors preventing the immune system of susceptible snails from destroying the developed parasite larvae. Therefore, the mechanism underlying the susceptibility of the snails should be investigated by studying the host-parasite interactions by light and electron microscopy.

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Differential lectin labelling of circulating hemocytes from Biomphalaria glabrata and Biomphalaria tenagophila resistant or susceptible to Schistosoma mansoni infection

Cited by 29 publications

References 32 publications

Behaviour of albino and melanic variants of Biomphalaria glabrata Say, 1818 (Mollusca: Planorbidae) following infection by Schistosoma mansoni Sambon, 1907

Behaviour of albino and melanic variants of Biomphalaria glabrata Say, 1818 (Mollusca: Planorbidae) following infection by Schistosoma mansoni Sambon, 1907

Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite

Histopathological study on susceptible and resistant Bulinus truncatus snails to infection with Schistosoma haematobium

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