Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection

Mota, Eduardo; Lenzi, Henrique Leonel

doi:10.1590/s0074-02762005000400012

Cited by 38 publications

(35 citation statements)

References 21 publications

(27 reference statements)

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“…One of the areas that require more research is the parasitic cycle in the final host, which was first described by Morera in 1973 and then reviewed by Mota and Lenzi in 2005. One of the factors that is still unclear is the reason why larvae in stage 3 show a preference for mesenteric lymphatic vessels (where they evolve to L4), or what is the influence of intestinal hormones when the male and female meet [34] [35].…”

Section: Discussionmentioning

confidence: 99%

<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports

Romero‐Alegría¹,

Belhassen‐García²,

Velasco‐Tirado³

et al. 2014

AID

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Introduction: Abdominal angiostrongyliasis is an infrequently diagnosed disease because it is little known and is usually well tolerated. Methods: We carried out a systematic review with PubMed as a search engine for the MedLine database, and we analysed the clinical, epidemiological and analytical parameters of this disease. Results: In total, reports of 27 case have been found, together with a series of 116 patients, which were later augmented up to 194 patients. In the results, we have observed a predominance of male patients, and Costa Rica, Brazil and the United States as the main countries of origin. Typical symptoms include abdominal pain on the right iliac fossa, with leukocytosis and eosinophilia. Discussion: There are some serological diagnostic methods, although lack of standardization leads to most of the diagnoses being reached via pathology. Surgery is the usual treatment approach. Although there are medical options, this is a controversial subject because of the low number of cases published in the literature, which implies an absence of solid studies.

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Section: Discussionmentioning

confidence: 99%

<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports

Romero‐Alegría¹,

Belhassen‐García²,

Velasco‐Tirado³

et al. 2014

AID

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“…However, MOTA & LENZI 12,13 , using two different animal models (Swiss Webster and Sigmodon hispidus) showed that the A. costaricensis presents, during its life cycle, an alternative migration to hepatic veins as a normal event of venous portal pathway, where the nematode matures and lays fertile eggs inside the liver. Then, according to MOTA & LENZI 12,13 , A. costaricensis adult worms can reach the liver by branches of hepatic artery and portal vein. Although identification of A. costaricensis in tissue specimen is confirmatory of AA, in many cases this is quite difficult due to the limited number of parasites causing the disease 15 .…”

Section: Discussionmentioning

confidence: 99%

Abdominal angiostrongyliasis: report of two cases with different clinical presentations

Rodriguez

Dequi

Peruzzo

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAbdominal angiostrongyliasis is a sporadic infectious disease caused by the nematode Angiostrongylus costaricensis. It usually presents as acute abdomen, secondary to mesenteric ischemia, and pronounced eosinophilia. In some cases its course is insidious and transient, and the diagnosis is suspicious. The disease is confirmed by the detection of A. costaricensis elements in surgical specimen. The treatment is supportive, with avoidance of antihelminthic administration due to a possible erratic migration followed by worsening of the disease. We report two cases, both with intense eosinophilia and serum IgG-ELISA positive to A. costaricensis. The first case presented ileal perforation and was surgically treated. The second one showed hepatic nodules at ultrasound and was only symptomatically treated, evolving to an apparent protracted resolution. These two cases exemplify different clinical forms of the disease, one of them with liver involvement.

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“…When rodents ingest the intermediate host or contaminated food, the infective larvae penetrate the intestinal wall and migrate through blood/lymphatic vessels to the heart, lungs, heart again and arterial circulation to reach the mesenteric arteries. There, the juveniles (L 5 ) grow to maturity, lay eggs in the vessels that migrate to the intestinal wall 19 . First stage larvae L 1 develop within eggs and, after hatching, they move to the intestinal wall toward the lumen.…”

Section: Morera and Céspedes (1971) Describedmentioning

confidence: 99%

Human infection by Angiostrongylus costaricensis in Venezuela: first report of a confirmed case

Incani

Caleiras²,

Rodríguez‐Martín³

et al. 2007

Rev. Inst. Med. trop. S. Paulo

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SUMMARYA proven case of human infection caused by Angiostrongylus costaricensis is reported for the first time in Venezuela. The patient was a 57-year-old female surgically operated because of signs of peritonitis with a palpable mass at the lower right quadrant of the abdomen. WBC count reported 16,600 cells/mm 3 , with 46% eosinophils. The tumoral aspect of ileocolic area and peritoneal lymph nodes prompted the resection of a large area of the terminal ileum, cecum, part of the ascending colon and a small part of the jejunum, where a small lesion was found. The pathology showed thickened areas of the intestinal wall with areas of hemorrhage and a perforation of the cecum. Histology showed intense eosinophil infiltration of the whole intestinal wall, granulomas with giant cells and eosinophils. Some of the granuloma surrounded round or oval eggs with content characterized by a large empty area, cells or embryo in the center, and sometimes nematode larvae. A cross section of an adult nematode worm was observed inside a branch of mesenteric artery. The intestinal affected area, the characteristics of the lesions, the presence of eggs in the submucosa with nematode larvae inside, and the observation of a nematode inside a mesenteric artery, makes sufficient criteria for the diagnosis of an infection by Angiostrongylus costaricensis.

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Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection

Cited by 38 publications

References 21 publications

<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports

<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports

Abdominal angiostrongyliasis: report of two cases with different clinical presentations

Human infection by Angiostrongylus costaricensis in Venezuela: first report of a confirmed case

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Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection

Cited by 38 publications

References 21 publications

&lt;i&gt;Angiostrongylus costaricensis&lt;/i&gt;: Systematic Review of Case Reports

&lt;i&gt;Angiostrongylus costaricensis&lt;/i&gt;: Systematic Review of Case Reports

Abdominal angiostrongyliasis: report of two cases with different clinical presentations

Human infection by Angiostrongylus costaricensis in Venezuela: first report of a confirmed case

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<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports

<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports