Analysis of expressed sequence tags from Trypanosoma cruzi amastigotes

Cerqueira, Gustavo C.; DaRocha, Wanderson D.; Campos, Priscila C.; Zouain, Claudia S.; Teixeira, Santuza Maria Ribeiro

doi:10.1590/s0074-02762005000400008

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…The EST sequencing projects that have followed this first initiative, including a larger numbers of clones, did not diverge from this first project. However, cDNAs from other developmental stages (e.g., trypomastigote and amastigote) were included in sequence database (Verdun et al 1998, Aguero et al 2004, Cerqueira et al 2005. These numbers show that a great deal of research effort should be focused on deciphering the codes behind the T. cruzi genome.…”

Section: What Information Can Be Extracted From a Trypanosomatid Est mentioning

confidence: 99%

Trypanosomatid EST: a neglected information resource regarding flagellated protozoa?

Brandão

2008

Mem. Inst. Oswaldo Cruz

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Section: What Information Can Be Extracted From a Trypanosomatid Est mentioning

confidence: 99%

Trypanosomatid EST: a neglected information resource regarding flagellated protozoa?

Brandão

2008

Mem. Inst. Oswaldo Cruz

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“…In the majority of the cases individual analyses of these datasets have been published (4,5,7–10). In previous versions of TcruziDB, EST data obtained from NCBI were available for download and sequence similarity searches, but they were not integrated with available genome data.…”

Section: Data Inventory Updatesmentioning

confidence: 99%

“…Since that time, the genome sequence has been published (1) together with a whole-genome proteomic analysis covering the four main life cycle stages of the parasite (3). Also during this period, new EST sequences were deposited in GenBank, adding EST coverage to the two life-cycle stages that occur in the mammalian host (4,5). …”

Section: Introductionmentioning

confidence: 99%

TcruziDB: an integrated, post-genomics community resource for Trypanosoma cruzi

Agüero¹

2006

Nucleic Acids Research

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TcruziDB () is an integrated post-genomics database for the parasitic organism, Trypanosoma cruzi, the causative agent of Chagas' disease. TcruziDB was established in 2003 as a flat-file database with tools for mining the unannotated sequence reads and preliminary contig assemblies emerging from the Tri-Tryp genome consortium (TIGR/SBRI/Karolinska). Today, TcruziDB houses the recently published assembled genomic contigs and annotation provided by the genome consortium in a relational database supported by the Genomics Unified Schema (GUS) architecture. The combination of an annotated genome and a relational architecture has facilitated the integration of genomic data with expression data (proteomic and EST) and permitted the construction of automated analysis pipelines. TcruziDB has accepted, and will continue to accept the deposition of genomic and functional genomic datasets contributed by the research community.

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