Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001 - A review

Arbiza, Juan; Delfraro, Adriana; Frabasile, Sandra

doi:10.1590/s0074-02762005000300001

Cited by 28 publications

(29 citation statements)

References 36 publications

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“…In Finland, the HRSV subgroup dominance changed every 2 years over 10 consecutive years (46), while in Rochester, NY, a cyclic pattern, consisting of 1 to 2 consecutive years of high subgroup A dominance followed by a single intervening year of subgroup B dominance or by codominance of both subgroups, was observed over a 15-year period (18). Similar subgroup occurrence patterns have been seen in Kenya, Uruguay, and the United States, where HRSV-B became predominant after 2 consecutive seasons of high subgroup A prevalence (3,7,37). During the 10 successive epidemic seasons investigated in Belgium, a regular 3-year cyclic pattern of subgroup occurrence was observed.…”

Section: Discussionsupporting

confidence: 57%

“…This genotype was reported to be predominant among HRSV-A strains during 3 consecutive seasons in a community in Japan (35) and in India (30) and has been the most frequently detected HRSV-A genotype in Sweden (34) and New Zealand (24) in recent years. Higher antigenic diversity among the GA5 strains is most likely responsible for the ability of this genotype to persist and prevail more frequently in certain communities (3,30). This study included only one hospital in Belgium, and the majority of patients were inhabitants of the Flemish part of Belgium.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological surveys have revealed that strains from both HRSV subgroups can be present in the same community during outbreaks; however, their relative proportions may differ between epidemics (3,4,10,20). HRSV has complex circulation patterns, with multiple genotypes or lineages cocirculating within the same community and replacement of the predominating genotypes with new ones over successive epidemic seasons (1,5,6,13,18,33).…”

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confidence: 99%

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Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons

et al. 2007

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Human respiratory syncytial virus (HRSV) is the leading viral cause of severe respiratory illness for infants and young children worldwide. Two major antigenic groups (A and B) of HRSV exist, and viruses from both subgroups can cocirculate during epidemics; however, their frequencies might differ between seasons. The subgroup prevalence and genotype distribution patterns of HRSV strains were investigated in a community in Belgium during 10 successive epidemic seasons (1996 to 2006). A regular 3-year cyclic pattern of subgroup dominance was observed, consisting of two predominant HRSV-A seasons, followed by a single HRSV-Bdominant year. HRSV infections with both subgroups were more prevalent among children younger than 6 months and had a peak incidence in December. The most frequently detected genotypes were GA5 and GB13, the latter including strains with the 60-nucleotide duplication in the G gene. Furthermore, GA5 remained the dominant HRSV genotype in two consecutive epidemic seasons twice during the study period. Additional variability was detected among the GB13 isolates, due to the usage of a novel termination codon in the G gene. Dual infections with both HRSV subgroups were detected for 9 patients, and subsequent infections with the heterologous HRSV subgroup were documented for 15 patients. Among five patients with homologous reinfections, only one was caused by HRSV-B. Our results support the hypothesis that the overall prevalence of HRSV-A over HRSV-B could be due to a more-transient subgroup A-specific immune protection.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons

et al. 2007

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“…In temperate climates, outbreaks occur yearly in the late fall, winter, or spring but not in the summer (22,29,61). Both RSV groups can be present in the same community, and their relative proportions may differ between epidemics (2,4,13,20), although group A viruses tend to predominate (8).…”

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confidence: 99%

Genetic Variability of Group A Human Respiratory Syncytial Virus Strains Circulating in Germany from 1998 to 2007

2009

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The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study the molecular epidemiology of RSV, more than 1,400 RSV isolates from human nasopharyngeal aspirates or nasal or throat swabs from patients with respiratory illness were identified and differentiated by TaqMan reverse transcription-PCR into groups A and B. RSV group A was dominant in seven out of nine epidemic seasons. Phylogenetic analysis revealed that RSV group A genotypes GA2 and GA5 circulated from 1998 to 2007. Genotype GA7 was present in only two seasons (1999 to 2000 and 2002 to 2003). Comparison of the synonymous mutation/nonsynonymous mutation ratios showed greater evidence for selection pressure for genotype GA2 (1.18) than for GA5 (4.34). Partial protein sequences were predicted to encode G proteins of 298 amino acids in length and in a few cases of G proteins of 297 amino acids in length. Amino acid analysis also revealed genotype-specific amino acid substitutions: two substitutions for genotype GA2, seven for GA5, and three for GA7. Two to four putative, genotype-specific N-linked glycosylation sites were determined. Predicted Oglycosylation sites included 22 to 34 residues. This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons.

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“…RSV is an enveloped RNA virus, classified into the genus Pneumovirus and Paramixoviridae family (Santos et al 2002;Hacking & Hull, 2002;Arbiza et al 2005). Seasonality is the main epidemiological feature of RSV, with annual outbreaks observed at regular intervals that vary according to the climate ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Climatic Factors Impact on RSV Infection Distribution in Children Attending Childcare at Northwest Region of São Paulo, Brazil

Simas¹,

Gardinassi²,

Nogueira³

et al. 2012

VR&R

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Respiratory syncytial virus (RSV) was detected in samples collected from children from 0 to 6 years of age with acute respiratory infection, attending public childcare on Northwest region of São Paulo, Brazil. RSV distribution was associated to seasonal climatic variables as temperature, rainfall and relative air humidity. We utilized samples of nasopharyngeal aspirate collected during the period of July 2003 to September 2005. RT-PCR was the chosen method for viral identification. Results showed that from the 817 samples (collected from 179 children), 7.7% (63/817) were RSV positive. In 2003, RSV was detected from July until October. In 2004, RSV infections occurred in March, May, June, July, October, November, and December. In 2005, RSV was detected in March, April, May, August, and September. RSV circulation patterns in childcare children showed seasonal distribution associated to decreases in temperature and relative air humidity. RSV was detected in childcare children as an important viral agent causing respiratory infections, with varying patterns of circulation into the cohort during the study period. Moreover, RSV distribution showed to be associated with the dry season on Northwest region of São Paulo, Brazil.

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Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001 - A review

Abstract: The variability of the G glycoprotein from human respiratory syncytial viruses (HRSV) (groups A and B)

Cited by 28 publications

References 36 publications

Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons

Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons

Genetic Variability of Group A Human Respiratory Syncytial Virus Strains Circulating in Germany from 1998 to 2007

Analysis of Climatic Factors Impact on RSV Infection Distribution in Children Attending Childcare at Northwest Region of São Paulo, Brazil

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