Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae

Correia, Heriberto; Medina, Rafael; Hernández, Alexandra; Bustamante, Ekaterina; Chakraburtty, Kalpana; Herrera, Flor

doi:10.1590/s0074-02762004000700012

Cited by 5 publications

(1 citation statement)

References 36 publications

(34 reference statements)

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“…First, we showed that inactive ribosomes from glucose‐depleted yeast are biochemical substrates of the complex (Fig ). Second, deletion of Stm1, that stabilizes ribosomal subunit interaction (Correia et al , ; Ben‐Shem et al , ) and therefore antagonizes dissociation, abolishes the need for the Dom34‐Hbs1 complex for recovery.…”

Section: Discussionmentioning

confidence: 99%

Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress

Elzen

Schuller

Green

et al. 2014

EMBO J

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Following translation termination, ribosomal subunits dissociate to become available for subsequent rounds of protein synthesis. In many translation-inhibiting stress conditions, e.g. glucose starvation in yeast, free ribosomal subunits reassociate to form a large pool of non-translating 80S ribosomes stabilized by the 'clamping' Stm1 factor. The subunits of these inactive ribosomes need to be mobilized for translation restart upon stress relief. The Dom34-Hbs1 complex, together with the Rli1 NTPase (also known as ABCE1), have been shown to split ribosomes stuck on mRNAs in the context of RNA quality control mechanisms. Here, using in vitro and in vivo methods, we report a new role for the Dom34-Hbs1 complex and Rli1 in dissociating inactive ribosomes, thereby facilitating translation restart in yeast recovering from glucose starvation stress. Interestingly, we found that this new role is not restricted to stress conditions, indicating that in growing yeast there is a dynamic pool of inactive ribosomes that needs to be split by Dom34-Hbs1 and Rli1 to participate in protein synthesis. We propose that this provides a new level of translation regulation.

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Section: Discussionmentioning

confidence: 99%

Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress

Elzen

Schuller

Green

et al. 2014

EMBO J

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Current awareness on yeast

2005

Yeast

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In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts. Each bibliography is divided into 10 sections. 1 Books, Reviews & Symposia; 2 General; 3 Biochemistry; 4 Biotechnology; 5 Cell Biology; 6 Gene Expression; 7 Genetics; 8 Physiology; 9 Medical Mycology; 10 Recombinant DNA Technology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. (4 weeks journals ‐ search completed 13th. Apr. 2005)

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Stm1p, a Ribosome-associated Protein, is Important for Protein Synthesis in Saccharomyces cerevisiae under Nutritional Stress Conditions

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Baby

Dyke

2006

Journal of Molecular Biology

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Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae

Abstract: A ribosome association factor (AF)

Cited by 5 publications

References 36 publications

Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress

Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress

Current awareness on yeast

Stm1p, a Ribosome-associated Protein, is Important for Protein Synthesis in Saccharomyces cerevisiae under Nutritional Stress Conditions

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