Respiratory syncytial virus infections during an epidemic period in Salvador, Brazil: viral antigenic group analysis and description of clinical and epidemiological aspects

Moura, Fernanda Edna Araújo; Borges, Leonardo Carletto; Portes, Silvana Augusta Rodrigues; Ramos, Eduardo Antônio Gonçalves; Siqueira, Marilda Mendonça

doi:10.1590/s0074-02762003000600005

Cited by 26 publications

(29 citation statements)

References 23 publications

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“…The finding that RSV infections were mainly associated with bronchiolitis and pneumonia/bronchopneumonia (60 and 46% of the cases, respectively), demonstrated that this agent was an important cause of lower respiratory tract infections, results that were also found by Nascimento et al (1991), Vieira et al (2001), Moura et al (2003), and Tsuchiya et al (2005). Moreover, the fact that approximately half of RSV infections (52/100) occurred in children under 6 mo., showed that patients in this age group are the most vulnerable to infections caused by RSV, despite the presence of maternal antibodies (Queiróz et al 2002).…”

Section: Discussionmentioning

confidence: 89%

Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil

Costa

Yokosawa²,

Mantese³

et al. 2006

Mem. Inst. Oswaldo Cruz

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The main viruses involved in acute respiratory diseases among children are: respiratory syncytial virus (RSV), influenzavirus (FLU), parainfluenzavirus (PIV), adenovirus (AdV), human rhinovirus (HRV), and the human metapneumovirus (hMPV). The purpose of the present study was to identify respiratory viruses that affected children younger than five years old in Uberlândia, Midwestern Brazil. Nasopharyngeal aspirates from 379 children attended at Hospital de Clínicas (HC/UFU), from 2001 to 2004, with acute respiratory disease, were collected and tested by immunofluorescence assay (IFA) to detect RSV, FLU A and B, PIV 1, 2, and 3 and AdV, FLU A and B in 9.5% (36/379), PIV 1, 2 and 3 in 6.3% (24/ 379) and AdV in 3.7% (14/379). HRV were detected in 29. 6% (112/379) Viruses are the most frequent agents that cause acute respiratory infections (ARIs) and are responsible for a considerable percentage of childhood mortality (Williams et al. 2002). In Brazil, some reports from different geographical areas has revealed the viruses as the main cause of respiratory infections, as related in the cities of Fortaleza (Arruda et al. 1991), Rio de Janeiro (Nascimento et al. 1991), São Paulo (Miyao et al. 1999, Vieira et al. 2001), and Curitiba (Tsuchiya et al. 2005.The most important viruses involved in ARI are: respiratory syncytial virus (RSV), influenzaviruses types A and B (FLU A/B), parainfluenzavirus (PIV), adenovirus (AdV), human rhinovirus (HRV), and the human metapneumovirus (hMPV) (Miyao et al. 1999, Kuiken et al. 2003, Tsuchiya et al. 2005). The last one was recently identified by Hoogen et al. (2001).RSV is the main cause of viral lower respiratory tract illness in children (Miyao et al. 1999), particularly in those younger than six months old (mo.) (Queiróz et al. 2002. In addition, RSV infections are responsible for most cases of severe symptoms such as bronchiolitis with recurrent wheezing and pneumonia (Calegari et FLU is a serious public health problem worldwide, were children constitute the age group most affected (Neuzil et al. 2002). Although many infections caused by FLU could be prevented by effective vaccination program, it has been predicted that a pandemic is likely to emerge in a near future (Cox et al. 2003), caused by a virus variant not covered by the current vaccine, requiring, thus, a constant epidemiological surveillance.PIV seems to have pattern of seasonal occurrence and is considered an important cause of respiratory illnesses, particularly among young children (Monto 2002).AdV infections are common in all age groups, causing both hospital-and community-acquired epidemics. Moreover, AdV has been associated with hospitalizations of near-fatal asthma patients (Tan et al. 2003) and with cases of acute otitis media in children younger than two years old (Monobe et al. 2003).HRV is responsible for the majority of common colds during winter, causing upper respiratory infections (Arruda et al. 1991, Savolainen et al. 2003 and is considered a risk factor for acute otitis media (Monobe at al. 2003). ...

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Section: Discussionmentioning

confidence: 89%

Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil

Costa

Yokosawa²,

Mantese³

et al. 2006

Mem. Inst. Oswaldo Cruz

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“…Several studies indicate that RSV A and B alternate in prevalence during successive years (Mufson et al 1988, Sullender 2000. In Brazil, studies have identified the simultaneous circulation of the RSV groups in different years in the Northern (Mello & Silva 1992), Northeastern (Moura et al 2003), Southeastern (Siqueira et al 1991, Cintra et al 2001 and Southern regions (Straliotto et al 2001), but, to date, no epidemiological pattern for each specific RSV group has been established for Central Brazil.…”

mentioning

confidence: 99%

Prevalence and clinical aspects of respiratory syncytial virus A and B groups in children seen at Hospital de Clínicas of Uberlândia, MG, Brazil

Oliveira¹,

Freitas²,

Ribeiro³

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…Na última década, houve descrição de mais um genótipo (SAV1) do grupo A (totalizando oito subgrupos) e mais 3 genótipos (SAB1, SAB2 e SAB3) do grupo B (totalizando 7 subgrupos). Outros trabalhos identificaram mais um genótipo BA do grupo B do hRSV, circulando na América do Sul e nordeste da Ásia (Venter et al, 2001;Moura et al, 2003;Trentro et al, 2006;Nagai et al, 2004;Scott et al, 2004).…”

Section: Características Antigênicasunclassified

“…Para algumas amostras seqüenciadas da proteína F e da proteína G não foi possível fazer a comparação entre as duas proteínas, por não obtermos a genotipagem da proteína G (amostras: 86/2004, 148/2004, 84/04, 197/04, 224/04, 222/04, 136/2004, 100/2004, 92/2004, 87/2004 e 315/2004). Com esses dados podemos constatar que o hRSV é uma importante causa de doença respiratória em lactentes, concordando com os dados da literatura de países desenvolvidos e em alguns países em desenvolvimento, onde o hRSV foi o principal agente de infecção viral das vias aéreas inferiores em crianças (Herreira-Rodriguez et al, 2007;Myao et al, 1999;Moura et al, 2003;Cintra et al, 2001;doNascimento et al, 2008;Souza et al, 2003). Um trabalho realizado por Herrera-Rodríguez et al Constatamos em nosso estudo que as infecções causadas pelo hRSV ocorreram nas estações de outono e inverno, com início no mês de março até junho.…”

Section: Comparação Entre As Sequências Da Proteína F E Os Genótipos unclassified

Ausência de escapes mutantes para o medicamento palivizumab® do Vírus Respiratório Sincicial Humano (hRSV) circulante, na cidade de São Paulo durante o ano de 2004.

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Respiratory syncytial virus infections during an epidemic period in Salvador, Brazil: viral antigenic group analysis and description of clinical and epidemiological aspects

Cited by 26 publications

References 23 publications

Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil

Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil

Prevalence and clinical aspects of respiratory syncytial virus A and B groups in children seen at Hospital de Clínicas of Uberlândia, MG, Brazil

Ausência de escapes mutantes para o medicamento palivizumab® do Vírus Respiratório Sincicial Humano (hRSV) circulante, na cidade de São Paulo durante o ano de 2004.

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