Coexistence of antibodies to tick-borne agents of babesiosis and Lyme borreliosis in patients from Cotia county, State of São Paulo, Brazil

Yoshinari, Natalino Hajime; Abrão, Milena Garcia; Bonoldi, Virgínia Lúcia Nazário; Soares, Cleber Oliveira; Madruga, C. R.; Scofield, Alessandra; Massard, Carlos Luiz; Fonseca, Adivaldo Henrique da

doi:10.1590/s0074-02762003000300004

Cited by 38 publications

(54 citation statements)

References 21 publications

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“…[23][24][25] South America has a low number of reports of human babesiosis, including the first suspect case from the State of Pernambuco, a serological study in Colombia, a possible positive case in Poland that seems to have been acquired in Brazil, antibodies to Babesia in a study of co-infection with Lyme disease, and a case of a child with hepatoblastoma with a positive blood smear that suggests Babesia infection. [26][27][28][29][30] With the aim to investigate tick-borne zoonoses and to establish epidemiological data about these diseases in the northern region of the State of Espírito Santo, we visited six counties in this area, and performed serology and molecular biology to the most common tick-borne diseases in humans and domestic animals in Brazil. These counties were selected because of their recent history of BSF laboratory-confirmed cases, including fatal cases (State of Espírito Santo Health Secretary, unpublished data), and/or suspect cases of BYS (Yoshinari NH, unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Survey for Tick-Borne Zoonoses in the State of Espirito Santo, Southeastern Brazil

Spolidorio¹,

Labruna²,

Machado³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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Section: Introductionmentioning

confidence: 99%

Survey for Tick-Borne Zoonoses in the State of Espirito Santo, Southeastern Brazil

Spolidorio¹,

Labruna²,

Machado³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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“…On the contrary, it was reported emergence of Brazilian LD in a laboratory researcher, accidentally bitten by Amblyomma cajennense tick (Yoshinari NH-personal communication). Ticks of genus Rhipicephalus were also suspected to transmit spirochetes, due to coexistence of antibodies to B. burgdorferi and Babesia bovis in Brazilian LD patients 44 .…”

Section: Introductionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this study was to evaluate the epidemiological, clinical and laboratorial profile of patients with Baggio-Yoshinari Syndrome (BYS), who underwent internment at the Instituto de Infectologia Emilio Ribas in São Paulo, Brazil, during the period from July 1990 to July 2006. BYS is a new Brazilian tick-borne disease caused by Borrelia burgdorferi sensu lato microorganisms that resembles features of Lyme disease (LD), except for its epidemiological, clinical and laboratorial particularities. From 60 patients' records with positive serology to B. burgdorferi done by ELISA and Western-blotting methods, 19 cases were diagnosed as having BYS, according to criteria adopted at LIM-17 HCFMUSP, the Brazilian Reference Laboratory for the research of BYS. The other 41 remaining patients displayed miscellaneous infections or auto-immune processes. The beginning of symptoms in BYS group varied from one day to six years, from the onset of the disease. Four of 19 patients were included in acute disease stage, and 15 in latent. General unspecific symptoms were identified in almost all cases, with high frequencies of fever (78.9%) and lymphadenomegaly (36.8%). Six patients had skin lesions (31.5%); six arthralgia or arthritis (31.5%) and eight neurological symptoms (42%). Interestingly, two patients showed antibodies directed to B. burgdorferi exclusively in cerebrospinal fluid. Since BYS is a new emergent Brazilian zoonosis and its diagnosis is sometimes complex, all the new knowledge about BYS must be scattered to Brazilian Medical specialists, aiming to teach them how to diagnose this amazing tick-borne disease and to avoid its progression to chronic irreversible sequels.

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“…There are few studies concerning tick-borne diseases like babesiosis, ehrlichiosis, bartonellosis, rickettsiosis other than Brazilian spotted fever in Brazil. We have recently shown that patients with LDLS present a high incidence of serum antibodies against Babesia bovis, suggesting that the tick transmitter of LDLS could also carry Babesia (51). When the fever is very high (more than 40ºC) and is accompanied by important hematological findings such as anemia, reduced platelet numbers or evidence of peripheral hemolysis, the hypothesis of co-infection with Babesia should be considered, and serology for this blood parasite should be performed.…”

Section: Treatment Of Lyme Disease-like Syndromementioning

confidence: 99%

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Mantovani

Costa²,

Gauditano

et al. 2007

Braz J Med Biol Res

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An emerging clinical entity that reproduces clinical manifestations similar to those observed in Lyme disease (LD) has been recently under discussion in Brazil. Due to etiological and laboratory particularities it is named LD-like syndrome or LD imitator syndrome. The condition is considered to be a zoonosis transmitted by ticks of the genus Amblyomma, possibly caused by interaction of multiple fastidious microorganisms originating a protean clinical picture, including neurological, osteoarticular and erythema migrans-like lesions. When peripheral blood of patients with LD-like syndrome is viewed under a dark-field microscope, mobile uncultivable spirochete-like bacteria are observed. PCR carried out with specific or conservative primers to recognize Borrelia burgdorferi sensu stricto or the genus Borrelia has been negative in ticks and in biological samples. Two different procedures, respectively involving hematoxylin and eosin staining of cerebrospinal fluid and electron microscopy analysis of blood, have revealed spirochetes not belonging to the genera Borrelia, Leptospira or Treponema. Surprisingly, co-infection with microorganisms resembling Mycoplasma and Chlamydia was observed on one occasion by electron microscopy analysis. We discuss here the possible existence of a new tick-borne disease in Brazil imitating LD, except for a higher frequency of recurrence episodes observed along prolonged clinical follow-up.

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Coexistence of antibodies to tick-borne agents of babesiosis and Lyme borreliosis in patients from Cotia county, State of São Paulo, Brazil

Cited by 38 publications

References 21 publications

Survey for Tick-Borne Zoonoses in the State of Espirito Santo, Southeastern Brazil

Survey for Tick-Borne Zoonoses in the State of Espirito Santo, Southeastern Brazil

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

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