Achievements of schistosomiasis control in China

Yuan, Hao; Jiang, Qingwu; Zhao, Genming; He, Na

doi:10.1590/s0074-02762002000900036

Cited by 40 publications

(25 citation statements)

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“…Historically, Jiangsu Province suffered from a very high prevalence of schistosomiasis japonica in China, 10 out of the 13 cities of the province were endemic for S. japonicum , with accumulated schistosomiasis cases of more than 2.5 million, and accumulated snail habitats of about 1.5 billion m 2 [7,9,10,38]. During the past 5 decades, the Jiangsu Provincial government placed a high priority on the control of schistosomiasis and had carried out many control programs.…”

Section: Discussionmentioning

confidence: 99%

“…In China, concerted control effects since the 1950s have dramatically reduced the number of the areas endemic for the parasite as well as the burden of disease among humans [7-10]. Nevertheless, in the remaining core endemic regions, mainly located along the middle and lower reaches of the Yangtze River and some mountainous areas of provinces of Yunnan and Sichuan, over 0.7 million people are estimated to be infected, with a further 30 million at risk of infection [11].…”

Section: Introductionmentioning

confidence: 99%

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Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008

Wang

Liang

et al. 2011

Parasites Vectors

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BackgroundSchistosomiasis japonica remains a major public health concern in China. There are many interventions implemented to control the transmission of the disease. The purpose of the present study was to investigate the effects of an integrated control strategy for schistosomiasis control.MethodsAn integrated control strategy for schistosomiasis japonica with emphasis on removing cattle from snail-infested grasslands, providing farmers with mechanized farm equipment, improving sanitation by supplying tap water and building lavatories and latrines and providing boats with fecal-matter containers was implemented in 107 villages of the lower reaches of the Yangtze River, Jiangsu Province, China, during a 32-month period from May 2005 to 2008, and the effectiveness was investigated.ResultsFollowing the effects of the comprehensive control, the snail habitat, infected snail habitat, snail infection rate, and S. japonicum prevalence in both humans and livestock all appeared a declining trend year by year, with reductions of 47.88%, 94.29%, 92.55%, 96.94%, and 100% compared with those before the comprehensive control. In addition, all of the 17 counties achieved the infection control in 2007, and 7 reached the criteria of transmission control in 2008. The confirmed snail habitats reduced from 107 to 20, and the acute infections have also been controlled for 2 successive years since 2007.ConclusionsThe integrated control strategy for schistosomiasis japonica is effective to control the transmission of S. japonicum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008

Wang

Liang

et al. 2011

Parasites Vectors

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“…Based on the epidemiological profiles and status of schistosomiasis and the national social and economic situation, integrated strategies have been proposed for schistosomiasis control in China [62], aiming to eliminate this public health concern in the country through integration of multi-sectoral resources and multidisciplinary tools [63–65]. Until late 1990s, schistosomiasis elimination had been achieved in 5 out of the 12 endemic provinces in China [66–68]. Notably, the wide implementation of the integrated strategy with emphasis on infectious source control throughout the main endemic foci of China since 2004 has been proved to greatly facilitate the progress towards the elimination of schistosomiasis in the country [26, 27, 69–80].…”

Section: Discussionmentioning

confidence: 99%

A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014

Wang

YinPing³

et al. 2017

Infect Dis Poverty

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BackgroundAlthough great success has been achieved, schistosomiasis remains a major public health concern in China, and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangtze River. In this longitudinal study, we evaluated the effectiveness of a multidisciplinary, integrated approach for schistosomiasis elimination in a historically hyper-endemic region in the lower reaches of the Yangtze River, China over the 10-year period from 2005 through 2014.MethodsA three-step roadmap for schistosomiasis elimination was designed in the study site, and multidisciplinary, integrated interventions were implemented by the health, agriculture, water resources development, land and resources, and forestry sectors from 2005 to 2014, including chemotherapy for infected individuals, health education, management of the source of Schistosoma japonicum infection, and intermediate host snail control. The annual number of schistosomiasis patients, S. japonicum infection in humans, bovines and Oncomelania hupensis snails, and water infectivity were observed to assess the effectiveness of the multidisciplinary, integrated approach for the elimination of schistosomiasis.ResultsThere was a tendency towards a gradual decline in both the number of schistosomiasis cases and the prevalence of S. japonicum human infection across the study period from 2005 through 2014. No S. japonicum human infection was detected since 2012, and no acute infection was seen since 2006. During the study period, no infection was found in bovines, and a 0.03% overall infection rate was observed in O. hupensis snails. Since 2009, no infected snails were identified, and the area of both snail habitats and infected snail habitats appeared a reduction over the study period. Following the 3-year multidisciplinary, integrated control, infection control was achieved, and transmission control was achieved after 6-year implementation, with all infected snails and water infectivity eliminated; in addition, the 10-year implementation resulted in interruption of schistosomiasis transmission in the study site in 2014.ConclusionsThe results of the present 10-year longitudinal study demonstrate that the multidisciplinary, integrated approach is effective for the elimination of schistosomiasis as a public health problem in the lower reaches of the Yangtze River, China.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-017-0270-x) contains supplementary material, which is available to authorized users.

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“…When compared with cPCR and qPCR assays, ddPCR has higher diagnostic accuracy, and is able to provide absolute quantification, both features being beneficial in the support of disease control and elimination programs. These characteristics are particularly important in low schistosomiasis transmission areas with low prevalence/intensity infections common in areas in China where an extensive control program has been ongoing for many years (Minggang and Zheng, 1999;Yuan et al, 2002). …”

Section: Accepted Manuscriptmentioning

confidence: 99%

Optimisation of a droplet digital PCR assay for the diagnosis of Schistosoma japonicum infection: A duplex approach with DNA binding dye chemistry

Weerakoon

Gordon

Gobert

et al. 2016

Journal of Microbiological Methods

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Schistosomiasis is a chronically debilitating helminth infection with a significant socioeconomic and public health impact. Accurate diagnostics play a pivotal role in achieving current schistosomiasis control and elimination goals. However, many of the current diagnostics procedures, which rely on detection of schistosome eggs, have major limitations including lack of accuracy and the inability to detect pre-patent infections. DNA-based detection methods provide a viable alternative to the current tests commonly used for schistosomiasis diagnosis. Here we describe the optimisation of a novel droplet digital PCR (ddPCR) duplex assay for the diagnosis of Schistosoma japonicum which provides improved detection sensitivity and specificity. The assay involves the amplification of two specific and abundant target gene sequences in S. japonicum; a retrotransposon (SjR2) and a portion of a mitochondrial gene (nad1). The assay detected target sequences in different sources of schistosome DNA isolated from adult worms, schistosomules and eggs, and exhibits a high level of specificity, thereby representing an ideal tool for the detection of low levels of parasite DNA in different clinical samples including parasite cell free DNA in the host circulation and other bodily fluids. Moreover, being quantitative, the assay can be used to determine parasite infection intensity and, could provide an important tool for the detection of low intensity infections in low prevalence schistosomiasis-endemic areas.

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Achievements of schistosomiasis control in China

Cited by 40 publications

References 1 publication

Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008

Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008

A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014

Optimisation of a droplet digital PCR assay for the diagnosis of Schistosoma japonicum infection: A duplex approach with DNA binding dye chemistry

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