Studies on the production and regulation of interleukin, IL-13, IL-4 and interferon-gamma in human Schistosomiasis mansoni

Morais, Clarice Neuenschwander Lins de; Souza, Joelma Rodrigues de; Melo, Wlademir; Aroucha, Marcílio L; Domingues, Ana Lúcia Coutinho; Wynn, Thomas A.; Abath, Frederico G. C.; Montenegro, Sílvia Maria Lucena

doi:10.1590/s0074-02762002000900023

Cited by 7 publications

(13 citation statements)

References 9 publications

(14 reference statements)

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“…However type 1 (IFN-γ) cytokines and type 2 (IL-4 and IL-13) cytokines exhibit opposing roles in human schistosomiasis mansoni (Morais et al 2002, Abath et al 2006.…”

Section: Discussionmentioning

confidence: 99%

“…However, other authors suggested that IL-13 levels tend to be higher during the pre-fibrosis phase and can function as an intermittent inducer of fibrosis (Morais et al 2002, Ribeiro de Jesus et al 2004.…”

mentioning

confidence: 97%

“…On the other hand, type 2-associated cytokines such as interleukin (IL), IL-4, IL-13 and IL-10 inhibit classical macrophage activation and have been implicated in granuloma formation and fibrogenesis around tissue-deposited eggs (Wynn & Cheever 1995, Hesse et al 2001, Morais et al 2002. Most importantly, it has been observed that IL-13, but not IL-4, is the major type 2 cytokine driving type I and III collagen mRNA production and hepatic fibrosis in infected mice (Wynn et al 1993, Chiaramonte et al 1999a).…”

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confidence: 99%

“…Most importantly, it has been observed that IL-13, but not IL-4, is the major type 2 cytokine driving type I and III collagen mRNA production and hepatic fibrosis in infected mice (Wynn et al 1993, Chiaramonte et al 1999a). In the context of the type 1/type 2 cytokine paradigm, data from mice and humans have categorized schistosomiasis as a predominantly type 2 disease (Wynn & Cheever 1995, Abbas et al 1996, Allen & Maizels 1997, Fallon 2000, Morais et al 2002. A type 2 response generally causes morbidity and is detrimental to the host.…”

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confidence: 99%

“…However, recent data generated in the murine model suggests that the original distinct categorization of schistosome pathology being caused by type 2 cytokines is misleading. More convincing evidence from schistosome-infected humans suggests that a pro-inflammatory type 1 response is the real cause of morbidity (Fallon 2000, Morais et al 2002. Previous studies have shown that the pattern of cytokine production changes at different stages of human schistosomiasis.…”

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confidence: 99%

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Cytokine profile associated with chronic and acute human schistosomiasis mansoni

Morais

Souza

Melo

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…However type 1 (IFN-γ) cytokines and type 2 (IL-4 and IL-13) cytokines exhibit opposing roles in human schistosomiasis mansoni (Morais et al 2002, Abath et al 2006.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cytokine profile associated with chronic and acute human schistosomiasis mansoni

Morais

Souza

Melo

et al. 2008

Mem. Inst. Oswaldo Cruz

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Cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin

et al. 2014

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The purpose of this study was to determine cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin. The study was conducted upon 100 mice that were divided into five groups; 20 each: uninfected control group, Schistosoma mansoni infected untreated mice (infected control), infected mice treated with praziquantel (PZQ), infected mice treated with silymarin and infected mice treated with both praziquantel and silymarin. 10 mice from each group were sacrificed at 10th and 18th weeks post infection respectively. Histopathological investigations were performed. Liver sections were stained with hematoxylin-eosin and Masson's trichrome stain to evaluate changes of granuloma sizes and numbers. Serum levels of the cytokines (TNF-a, IFN-c, IL-4 and TGF-b1) were assessed in the sera of all groups by immunoassay. The measured levels of cytokines (IFN-c, IL-4, TNF-a, TGF-b1) were found to be significantly increased in infected mice compared to normal control. At the same time, treated groups with silymarin alone or combined with PZQ showed significant decrease in IL-4, TNF-a and TGF-b1 levels compared to infected control. On the other hand, there was a significant increase in IFN-c level observed in all treated groups compared to infected control. In addition, the histopathological examination of the liver in the group treated with PZQ showed a reduction in the number of livers eggs granuloma at all periods of sacrification compared with the infected untreated group. However, there was more decrease in granulomas diameter in both silymarin treated group or combined with PZQ at all periods of sacrification when compared to infected untreated group. In conclusion; treatment with silymarin combined with PZQ in murine schistosomiasis could reduce hepatic fibrosis by their action on the production of pro-inflammatory cytokines.

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Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

et al. 2010

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Interleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway, which underlies both the host defense to helminthic infection and atopic diseases, including asthma. Although IL10 promoter polymorphisms are associated with increased atopy risk, IL10 variation has not been thoroughly explored in schistosomiasis-endemic populations. Three atopyrelated IL10 promoter polymorphisms (rs1800896, rs1800871 and rs1800872), complemented by six tagging single-nucleotide polymorphisms (SNPs), were genotyped in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area in Brazil. Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg counts, indicating burden of infection reflecting effectiveness of schistosomiasis host immunity, were performed using family-based transmission disequilibrium tests for quantitative traits (QTDTs). Alleles A, T and A at the three promoter SNPs rs1800896, rs1800871 and rs1800872 were associated with high tIgE levels in the same direction as in atopy populations (P ¼ 0.0008, 0.026 and 0.045), but not with egg counts. IL10 promoter polymorphisms appear to influence non-specific tIgE levels, but not schistosomiasis-specific immunity. The tagging SNP rs3024495 was associated with high S. mansoni egg counts (P ¼ 0.005), suggesting a novel locus in IL10 may influence clinically relevant burden of infection.

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Studies on the production and regulation of interleukin, IL-13, IL-4 and interferon-gamma in human Schistosomiasis mansoni

Abstract: The production and regulation of interleukin (IL)

Cited by 7 publications

References 9 publications

Cytokine profile associated with chronic and acute human schistosomiasis mansoni

Cytokine profile associated with chronic and acute human schistosomiasis mansoni

Cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin

Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

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