IS6110 fingerprinting of sensitive and resistant strains (1991-1992) of Mycobacterium tuberculosis in Colombia

Gómez‐Marín, Jorge Enrique; Franco, Clara Inés León; Guerrero, Martha Inírida; Rigouts, Leen; Portaels, Françoise

doi:10.1590/s0074-02762002000700013

Cited by 3 publications

(2 citation statements)

References 15 publications

(8 reference statements)

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“…Adenocarcinoma is the most common histologic type in this situation (2,3,10,11). Increased LC in patients with PT occurrence may be related to immunosuppression (1,9); On the other hand, the immunodepression caused by cancer or chemotherapy might increase the reactivation of TB in patients with solid tumors (4.9). When PT is diagnosed simultaneously with the diagnosis of neoplasia appears to be no change in the prognosis (7,10).…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer and Tuberculosis: A Case Report on a Patient with Concurrent Comorbidities in a Hospital of High Complexity in Fortaleza - CE-BR

Rocha¹

2014

CRJ

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Section: Discussionmentioning

confidence: 99%

Lung Cancer and Tuberculosis: A Case Report on a Patient with Concurrent Comorbidities in a Hospital of High Complexity in Fortaleza - CE-BR

Rocha¹

2014

CRJ

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“…These limitations could soon be overcome with advances in the field of PCR base genotyping techniques. Moreover, there are now some reference laboratories in developing countries with genotyping capabilities that want to support the tuberculosis control program with these new technologies (68). In theory these techniques could allow the widespread use of molecular epidemiology as a control measure in the activities of national tuberculosis programs in developing countries.…”

Section: Transmission and Tuberculosis Controlmentioning

confidence: 99%

Epidemiología molecular de la tuberculosis: métodos y aplicaciones

2004

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The resurgence of tuberculosis around the world has renewed interest in understanding the epidemiology and pathogenesis of this disease. A revolutionary advance in the field of tuberculosis research has been the development of molecular techniques that permit identification and tracking of individual strains of Mycobacterium tuberculosis. With these techniques, molecular epidemiology has been established as a new discipline that adds another dimension to the classical epidemiology of tuberculosis and has increased our understanding of the transmission dynamics of M. tuberculosis. The increased epidemiological knowledge has led to discovery of inadequacies in tuberculosis control programs; this information has helped garner resources for program improvement and has highlighted the need for the continuous surveillance of tuberculosis. Additional genetic methods are being developed based on the knowledge of the genome sequence of M. tuberculosis. These simpler and less costly genotyping techniques promise to expand the application of molecular epidemiology to developing nations (where 90% of the disease burden occurs) in support of national tuberculosis programs. Furthermore, these tools permit ever more effective probes into the dynamics of transmission, the population structure, evolution and pathogenesis of M. tuberculosis.Key words: tuberculosis, Mycobacterium tuberculosis/pathogenicity/drug effects, molecular epidemiology, genotype, DNA fingerprinting/methods, restriction fragment length polymorphins. Epidemiología molecular de la tuberculosis: métodos y aplicacionesLa reemergencia de la tuberculosis en el mundo ha despertado el interés en el entendimiento de la epidemiología y patogénesis de esta enfermedad. Un revolucionario avance en este campo de investigación ha sido el desarrollo de técnicas moleculares que permiten identificar y establecer la huella particular de cada cepa de M. tuberculosis. Con el uso de estas técnicas, y el establecimiento de la epidemilogia molecular como nueva disciplina se adicionó otra dimensión a la epidemiologia clásica de la tuberculosis y ha incrementado el conocimiento de la dinámica de la transmisión de M. tuberculosis dentro de una población. En el proceso han sido identificados problemas en los programas de control, lo cual ha ayudado a obtener recursos para su mejoramineto e implementación. Aún más, se ha resaltado la necesidad de continuar vigilando esta enfermedad. Otras metodologías genotípicas han sido desarrolladas a partir del conocimiento de la secuencia del genoma de M. tuberculosis. Estas metodologías genotípicas de fácil implementación y bajo costo se deben aplicar en países en vía de desarrollo, donde existe el 90% de la enfermedad, como apoyo a los programas de control de la tuberculosis. Estas herramientas permitirán conocer la dinámica de transmisión de la tuberculosis, la estructura de la población, la evolución y patogénesis de M. tuberculosis.Palabras clave: tuberculosis, Mycobacterium tuberculosis/patogenicidad/efecto de drogas, epidemiología molecular,...

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Diagnosis of pulmonary and extrapulmonary tuberculosis using an in-house PCR method in clinical samples from a middle-income resource setting

2011

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IS6110 fingerprinting of sensitive and resistant strains (1991-1992) of Mycobacterium tuberculosis in Colombia

Abstract: The standardized method to study the polymorphism of IS 6110 was used to characterize 53 isolates of Mycobacterium tuberculosis obtained during [1991][1992]

Cited by 3 publications

References 15 publications

Lung Cancer and Tuberculosis: A Case Report on a Patient with Concurrent Comorbidities in a Hospital of High Complexity in Fortaleza - CE-BR

Lung Cancer and Tuberculosis: A Case Report on a Patient with Concurrent Comorbidities in a Hospital of High Complexity in Fortaleza - CE-BR

Epidemiología molecular de la tuberculosis: métodos y aplicaciones

Diagnosis of pulmonary and extrapulmonary tuberculosis using an in-house PCR method in clinical samples from a middle-income resource setting

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