Concurrent cutaneous, visceral and ocular leishmaniasis caused by Leishmania (Viannia) braziliensis in a kidney transplant patient

Gontijo, Célia Maria Ferreira; Pacheco, Raquel S.; Oréfice, Fernando; Lasmar, Euler Pace; Silva, Eduardo Sérgio da; Melo, Maria Norma

doi:10.1590/s0074-02762002000500029

Cited by 63 publications

(73 citation statements)

References 16 publications

(14 reference statements)

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“…When this patient was treated with an antileishmaniacidal regimen of Amphotericin B, his meningitis resolved [43]. Finally, there are reports of patients who have cutaneous and ocular manifestations of leishmaniasis after renal transplant and immunosuppression [20].…”

Section: Recent Case Reports Of Neurologic Manifestations During Leismentioning

confidence: 90%

Neurologic Manifestations ofLeishmania spp.Infection

Petersen¹,

Greenlee²

2011

J. Neuroparasitolog.

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When listing common clinical signs of the spectra of Leishmania-derived diseases, neurologic malfunctions are not commonly included. Despite this, there are multiple reported instances both in human and veterinary medicine where neurologic manifestations, whether central or peripheral, are described. In this review, we describe neurologic manifestations seen during infection with Leishmania spp. with some discussion of the implicit effect of inflammation on the blood brain barrier in both medical and veterinary cases. Taken together, the material discussed here suggests that in patients from Leishmania-endemic areas, when observing neurologic symptoms, causation secondary to infection with Leishmania spp. should be highly considered.

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Section: Recent Case Reports Of Neurologic Manifestations During Leismentioning

confidence: 90%

Neurologic Manifestations ofLeishmania spp.Infection

Petersen¹,

Greenlee²

2011

J. Neuroparasitolog.

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“…While MCL usually follows a cutaneous infection, MCL has been reported as the first clinical manifestation of AIDS even before CL or other more typical AIDS-defining illnesses (135). In a kidney transplant patient, concurrent cutaneous, visceral, and ocular leishmaniases as a result of L. braziliensis infection were also described (239). Interestingly, one report noted that 20% to 40% of HIV-infected patients with VL do not exhibit splenomegaly, which is a typical clinical feature of VL in ICT individuals (395).…”

Section: Leishmaniamentioning

confidence: 99%

“…The antimonial compounds (usually sodium stibogluconate and meglumine antimoniate), miltefosine, and amphotericin B are the mainstay of antileishmanial therapy (10,17,158,239,464,488).…”

Section: Leishmaniamentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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“…Although DNA detection may not show the presence of viable parasites, additional results (observation of amastigotes and ELISA and IFAT positivity) confirmed the infection. Currently, L. braziliensis is considered a dermotrophic species in the human leishmaniasis disease complex, with isolation and detection of this species in the viscera only in cases of immunologically compromised patients GONTIJO et al, 2002). In wild and synantropic animals (considered potential reservoirs for L. braziliensis), such a distinction regarding tissue tropism does not exist (ROQUE et al, 2010;ROQUE & JANSEN, 2014), and the parasite may be detected in many organs.…”

Section: Discussionmentioning

confidence: 99%

Hepatozoon canis and Leishmania spp. coinfection in dogs diagnosed with visceral leishmaniasis

Morgado

Cavalcanti

Miranda

et al. 2016

Rev. Bras. Parasitol. Vet.

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This study describes the occurrence of dogs naturally co-infected with Hepatozoon canis and two Leishmania species: L. infantum or L. braziliensis. Four dogs serologically diagnosed with Visceral Leishmaniasis were euthanized. Liver and spleen samples were collected for histopathological analysis and DNA isolation. H. canis meronts were observed in tissues from all four dogs. H. canis infection was confirmed by PCR followed by sequencing of a fragment of 18S rRNA gene. Leishmania detection and typing was confirmed by ITS1' PCR-RFLP and parasite burden was calculated using ssrRNA quantitative qPCR. A DPP -Dual Path platform test was performed. One out (Dog #2) of four animals was asymptomatic. Dogs #1 and #4 were infected by L. infantum and were DPP test positive. Dogs #2 and #3 were infected by L. braziliensis and were DPP test negative. Furthermore, visceral dissemination was observed in Dogs #2 and #3, since L. braziliensis was detected in liver and spleen samples. The visceral dissemination of L. braziliensis associated with systemic signs suggested that this co-infection could influence the parasite burden and disease progression.Keywords: Hepatozoonosis, canine visceral leishmaniasis, Leishmania infantum, Hepatozoon canis, co-infection, Leishmania braziliensis. ResumoO presente estudo descreve a ocorrência de coinfecção com Hepatozoon canis e duas espécies de Leishmania (L. infantum ou L. braziliensis) em cães. Quatro cães sorologicamente diagnosticados com leishmaniose visceral foram eutanasiados. Amostras do baço e fígado foram submetidas à histopatologia e extração de DNA. Merontes de H. canis foram observados nos quatro cães. A infecção por H. canis foi confirmada por PCR e sequenciamento de um fragmento do gene 18S rRNA. A infecção por Leishmania e tipagem foram realizadas por PCR-RFLP do região intergênica ITS1. A carga parasitária foi calculada pela qPCR quantitativa baseada no gene ssrRNA. O teste DPP -Dual Path platform foi realizado. Apenas o Cão #2 era assintomático. Os cães #1 e #4 estavam infectados com L. infantum e foram positivos no DPP. Os cães #2 e #3 estavam infectados com L. braziliensis e foram negativos no DPP. Além disso, visceralização foi observada nos cães #2 e #3, nos quais L. braziliensis foi detectada em amostras de baço e fígado. A visceralização da L. braziliensis associada a sinais clínicos sistêmicos sugerem que esta coinfecção pode ter influenciado na carga parasitária e progressão da doença.Palavras-chave: Hepatozoonose, leishmaniose visceral canina, Leishmania infantum, Hepatozoon canis, coinfecção, Leishmania braziliensis.

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Concurrent cutaneous, visceral and ocular leishmaniasis caused by Leishmania (Viannia) braziliensis in a kidney transplant patient

Abstract: Although cases of leishmaniasis co-infection have been described in acquired immunodeficiency

Cited by 63 publications

References 16 publications

Neurologic Manifestations ofLeishmania spp.Infection

Neurologic Manifestations ofLeishmania spp.Infection

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Hepatozoon canis and Leishmania spp. coinfection in dogs diagnosed with visceral leishmaniasis

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