Search for Borrelia sp. in ticks collected from potential reservoirs in an urban forest reserve in the State of Mato Grosso do Sul, Brazil: a short report

Costa, Izaías Pereira da; Bonoldi, Virgínia Lúcia Nazário; Yoshinari, Natalino Hajime

doi:10.1590/s0074-02762002000500006

Cited by 24 publications

(28 citation statements)

References 8 publications

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“…B. burgdorferi had never been isolated or cultured in BSK, even when many enriched media were employed to culture biological materials from patients 12,38 , potential reservoir animals 1 or ticks collected at risk areas 6 .…”

Section: Introductionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this study was to evaluate the epidemiological, clinical and laboratorial profile of patients with Baggio-Yoshinari Syndrome (BYS), who underwent internment at the Instituto de Infectologia Emilio Ribas in São Paulo, Brazil, during the period from July 1990 to July 2006. BYS is a new Brazilian tick-borne disease caused by Borrelia burgdorferi sensu lato microorganisms that resembles features of Lyme disease (LD), except for its epidemiological, clinical and laboratorial particularities. From 60 patients' records with positive serology to B. burgdorferi done by ELISA and Western-blotting methods, 19 cases were diagnosed as having BYS, according to criteria adopted at LIM-17 HCFMUSP, the Brazilian Reference Laboratory for the research of BYS. The other 41 remaining patients displayed miscellaneous infections or auto-immune processes. The beginning of symptoms in BYS group varied from one day to six years, from the onset of the disease. Four of 19 patients were included in acute disease stage, and 15 in latent. General unspecific symptoms were identified in almost all cases, with high frequencies of fever (78.9%) and lymphadenomegaly (36.8%). Six patients had skin lesions (31.5%); six arthralgia or arthritis (31.5%) and eight neurological symptoms (42%). Interestingly, two patients showed antibodies directed to B. burgdorferi exclusively in cerebrospinal fluid. Since BYS is a new emergent Brazilian zoonosis and its diagnosis is sometimes complex, all the new knowledge about BYS must be scattered to Brazilian Medical specialists, aiming to teach them how to diagnose this amazing tick-borne disease and to avoid its progression to chronic irreversible sequels.

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Section: Introductionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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“…Epidemiological data have shown that 50% of the patients report a history of tick bite or have had close contact with these parasites, such as finding a tick on their clothing or on animals or soil of the visited areas. Veterinarians, geologists, botanists, fishermen, and hikers are more predisposed to contracting the infection since they frequently enter the ecosystems where ticks and bacterium-contaminated animals are found (3,4).…”

Section: Epidemiologymentioning

confidence: 99%

“…Studies carried out in risk areas, i.e., those with confirmed clinical LDLS cases, have shown that different wild animals such as small rodents, marsupials, and possibly other larger animals, participate as "reservoirs", since spirochetes can be visualized in the peripheral blood of these animals by dark-field microscopy (3)(4)(5). Uncultivable spirochetes have also been observed in the peripheral blood of cattle with arthritis and opossums (6).…”

Section: Epidemiologymentioning

confidence: 99%

“…In Brazil, there have been reports of accidental bites by A. cajennense causing erythema migrans and systemic complications. Furthermore, Costa et al (4,9) identified cases of LDLS patients associated with A. cajennense ticks in Campo Grande county, State of Mato Grosso do Sul, a geographic region where arthropods of the genus Ixodes were not collected during the studies described above.…”

Section: Epidemiologymentioning

confidence: 99%

“…Finally, from a clinical point of view, despite the presence of all the clinical manifestations of classic LD, the Brazilian disease differed by the high frequency of recurrence, especially in patients that had received delayed therapy during the initial phase of the disease (13). The differences described suggested the existence of a unique infectious disease in Brazil that was similar to LD, but with an unclear etiology, which initially received the denomination of Brazilian Lyme-like disease (2,4,5,9,14). Currently, we have chosen the denomination of LDLS or LDIS due to the presence of clinical manifestations similar to those found in LD, which imitate this zoonosis, but are caused by microorganisms that do not belong to the B. burgdorferi sensu lato complex.…”

Section: Background Of the Study Of Lyme Disease-like Syndrome In Brazilmentioning

confidence: 99%

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Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Mantovani

Costa²,

Gauditano

et al. 2007

Braz J Med Biol Res

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An emerging clinical entity that reproduces clinical manifestations similar to those observed in Lyme disease (LD) has been recently under discussion in Brazil. Due to etiological and laboratory particularities it is named LD-like syndrome or LD imitator syndrome. The condition is considered to be a zoonosis transmitted by ticks of the genus Amblyomma, possibly caused by interaction of multiple fastidious microorganisms originating a protean clinical picture, including neurological, osteoarticular and erythema migrans-like lesions. When peripheral blood of patients with LD-like syndrome is viewed under a dark-field microscope, mobile uncultivable spirochete-like bacteria are observed. PCR carried out with specific or conservative primers to recognize Borrelia burgdorferi sensu stricto or the genus Borrelia has been negative in ticks and in biological samples. Two different procedures, respectively involving hematoxylin and eosin staining of cerebrospinal fluid and electron microscopy analysis of blood, have revealed spirochetes not belonging to the genera Borrelia, Leptospira or Treponema. Surprisingly, co-infection with microorganisms resembling Mycoplasma and Chlamydia was observed on one occasion by electron microscopy analysis. We discuss here the possible existence of a new tick-borne disease in Brazil imitating LD, except for a higher frequency of recurrence episodes observed along prolonged clinical follow-up.

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Borreliosis

Mafra¹,

Montandon²

2016

Arthropod Borne Diseases

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Search for Borrelia sp. in ticks collected from potential reservoirs in an urban forest reserve in the State of Mato Grosso do Sul, Brazil: a short report

Cited by 24 publications

References 8 publications

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Borreliosis

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