Schistosomal myeloradiculopathy due to Schistosoma mansoni: report on 23 cases

Nobre, Vandack; Silva, Cleison Sanches; Ribas, João Gabriel Ramos; Rayes, Abdunnabi Ahmed Mustafa; Serufo, José Carlos; Lana-Peixoto, M. A.; Marinho, Rosana F. Z.; Lambertucci, José Roberto

doi:10.1590/s0074-02762001000900020

Cited by 46 publications

(51 citation statements)

References 12 publications

(13 reference statements)

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“…Literature data demonstrate that there is a clear predominance of schistosomiasis in men compared to women (Peregrino et al 1988, 2002, Brito et al 1992, Nobre et al 2001, Santos et al 2001. In the present study, among the patients with SMR, 66.2% were male.…”

Section: Discussionsupporting

confidence: 49%

“…Nobre et al (2001) and Santos et al (2001) found higher frequencies of SMR cases among adults at mean ages of 24 and 28 years, respectively. Silva et al (2004) reported a mean of 26 years of age and a range from 1-68 years.…”

Section: Discussionmentioning

confidence: 91%

“…In the present study, among the patients with SMR, 66.2% were male. The predominance of the infection in the male sex may be explained by the fact that men are more frequently exposed to schistosomes, for example in rivers and lakes, because of their professional and/or leisure activities which also require greater physical strength (Nobre et al 2001, Santos et al 2001.…”

Section: Discussionmentioning

confidence: 99%

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Clinical-epidemiologic profile of the schistosomal myeloradiculopathy in Pernambuco, Brazil

Araújo

Silva

Santos

et al. 2010

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Clinical-epidemiologic profile of the schistosomal myeloradiculopathy in Pernambuco, Brazil

Araújo

Silva

Santos

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…Dada a necessidade de critérios para o diagnóstico presuntivo da esquistossomose medular, o Centers for Disease Control and Prevention (CDC) estabeleceu como parâmetros, a presença de sintomas neurológicos envolvendo a porção inferior da medula torácica e superior da lombar, além da demonstração da infestação pelo Schistosoma por método complementar, microscópico ou sorológico, associada à exclusão de outras causas de mielite transversa 9,10 . No entanto, embora seja inquestionável a contribuição desses exames para o diagnós-tico da neuroesquistossomose, não há método que forneça alterações patognomônicas da doença.…”

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Aspectos eletromiográficos preditores da evolução motora de pacientes com neuroesquistossomose

Correia

Júnior

Lins³

et al. 2007

Arq. Neuro-Psiquiatr.

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RESUMO -A neuroesquistossomose na forma mielorradicular é freqüentemente observada nos pacientes que residem no Nordeste do Brasil. Apesar disso, a evolução dos seus distúrbios neurológicos e padrões eletromiográficos são pouco estudados nesse grupo de pacientes. O objetivo deste estudo foi descrever e comparar a evolução motora com as anormalidades eletromiográficas de pacientes com neuroesquistossomose. Foram realizadas eletromiografias dos membros inferiores em 21 pacientes com diagnóstico presuntivo de radiculomielite esquistossomótica. O padrão eletromiográfico de 95,2% dos casos foi de multirradiculopatia axonal lombo-sacra, havendo extensão variável de desnervação, com predomínio de L 2 a S 2 . Foram identificados graus variáveis de paraparesia, havendo evolução motora mais favorável nos pacientes com envolvimento de menor número de raízes. A eletromiografia poderá fornecer dados prognósticos da evolução motora dos pacientes com radiculomielite esquistossomótica.PALAVRAS-CHAVE: neuroesquistossomose, eletromiografia, prognóstico. Electromyografic patterns predictive of motor evolution in neuroschistosomiasisABSTRACT -Neuroschistosomiasis in myeloradicular pattern is frequently observed in patients from Northeast of Brazil. Despite of this, the evolution of neurologic and electromyografic patterns is not well studied in this group of patients. The aims of this study were to describe and compare the clinic and electromyografic abnormalities of patients with neuroschistosomiasis and radicular involvement. We analyzed 21 electromyographic exams of the lower limbs carried out in the initial presentation of the disease. Electromyographic pattern of 95.2% of patients was compatible to axonal lombosacral multirradiculopathy, with variable denervation extension, but predominanthy from levels L 2 to S 2 . There was variable degree of deficit in the lower limbs, and the follow-up of motor disturbances was better more frequently when the roots were involved in smaller number. Electromyography should permit to know the motor prognosis of patients with myeloradiculitis due schistosomiasis.KEY WORDS: neuroschistosomiasis, electromyography, diagnosis. Do ponto de vista epidemiológico, a esquistossomose mansônica acomete cerca de 10% da população brasileira, estimando-se haver 17 milhões de esquistossomóticos no Brasil 1 . Segundo a Organização Mundial de Saúde, a maioria dos dados clínicos e laboratoriais, relativos ao Schistosoma mansoni, provêm do Brasil 2 . No mundo, estima-se ser a segunda doença parasitária de maior incidência, sendo sobrepujada apenas pela malária 3,4 . As formas de acometimento neurológico, na infestação pelo S. mansoni, são classificadas de maneira não uniforme na literatura [5][6][7] . Em diversos estudos foi adotada a classificação de Peregrino, cujas formas e freqüências são: mielorradiculítica (44%), mielítica (29,4%), pseudotumoral (24,7%), além da forma radiculítica pura e da síndro-me da artéria espinhal anterior, relatadas com menor freqüência na literatura 8 .O diagnóstico de certeza da n...

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“…The prevalence of schistosomal myelopathy is probably under-estimated and the disorder under-diagnosed 14,23 . A favorable outcome depends on early diagnosis with immediate treatment 51 as this approach is frequently associated with a full recovery of all neurological functions 37 . Diagnosis remains difficult.…”

Section: Resultsmentioning

confidence: 99%

Neuroschistosomiasis due to Schistosoma mansoni: a review of pathogenesis, clinical syndromes and diagnostic approaches

Nascimento‐Carvalho

Moreno-Carvalho²

2005

Rev. Inst. Med. trop. S. Paulo

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SUMMARYNeuroschistosomiasis (NS) is the second most common form of presentation of infection by the trematode, Schistosoma mansoni. Granulomatous inflammatory reaction occurs as a result of schistosome eggs being transmitted to spinal cord or brain via the vascular system, or by inadvertent adult worm migration to these organs. The two main clinical syndromes are spinal cord neuroschistosomiasis (acute or subacute myelopathy) and localized cerebral or cerebellar neuroschistosomiasis (focal CNS impairment, seizures, increased intracranial pressure). Presumptive diagnosis of NS requires confirming the presence of S. mansoni infection by stool microscopy or rectal biopsy for trematode eggs, and serologic testing of blood and spinal fluid. The localized lesions are identified by signs and symptoms, and confirmed by imaging techniques (contrast myelography, CT and MRI). Algorithms are presented to allow a stepwise approach to diagnosis.

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Schistosomal myeloradiculopathy due to Schistosoma mansoni: report on 23 cases

Cited by 46 publications

References 12 publications

Clinical-epidemiologic profile of the schistosomal myeloradiculopathy in Pernambuco, Brazil

Clinical-epidemiologic profile of the schistosomal myeloradiculopathy in Pernambuco, Brazil

Aspectos eletromiográficos preditores da evolução motora de pacientes com neuroesquistossomose

Neuroschistosomiasis due to Schistosoma mansoni: a review of pathogenesis, clinical syndromes and diagnostic approaches

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