Antimalarial chemotherapy. Mechanisms of action, resistance, and new directions in drug discovery

Krettli, Antoniana U.

doi:10.1590/s0074-02762001000800028

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quinine was originally extracted from the bark of the Cinchona (quina-quina) tree, used by native inhabitants of South America for the alleviation of malaria symptoms (Achan et al, 2011). The compound was isolated by Pierre Joseph Pelletier and Joseph Caventou in 1820 (Krettli, 2001) and completely synthesized in 1945 by Woodward & Doering (1945). Quinine has long been used to treat malaria.…”

Section: Resultsmentioning

confidence: 99%

Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum

Pereira

Luca

Abichabki

et al. 2021

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting in significant economic losses. There is no commercial treatment for neosporosis, and drug repositioning is a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine and tetracycline on N. caninum proliferation. The IC50 concentrations in N. caninum were compared to the current information based on previous studies for Plasmodium and Toxoplasma gondii, correlating to the described mechanisms of action of each tested drug. The inhibitory patterns indicate similarities and differences among N. caninum, Plasmodium and T. gondii. For example, atovaquone demonstrates high antiparasitic activity in all the analyzed models, while chloroquine does not inhibit N. caninum. On the other hand, tetracycline is effective against Plasmodium and N. caninum, despite its low activity in T. gondii models. The repurposing of antimalarial drugs in N. caninum is a fast and inexpensive way to develop novel formulations using well-established compounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum

Pereira

Luca

Abichabki

et al. 2021

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

show abstract

Diagnosis and management of malaria in the intensive care unit

Akafity,

Kumi,

Ashong

2024

Journal of Intensive Medicine

View full text Add to dashboard Cite

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

124

View full text Add to dashboard Cite

Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemotherapeutical agents are needed for the treatment of malaria. Many plant species are used in traditional medicines of malarious countries and a relatively few number of these have been investigated for evaluation of their antimalarial effect. Still lower is the number of those that have had the active natural compounds isolated and the toxicity determined. This area is, then, of great research interest. A discovery project of antimalarial natural products from plants traditionally used to treat malaria must include in vitro and in vivo assays as well as bioguided isolation of active compounds. The final products would be antimalarial chemical entities, potential new drugs or templates for new drugs development, and/or standardized antimalarial extracts which are required for pre-clinical and clinical studies when the aim is the development of effective and safe phythomedicines. This review discusses these two approaches, presents briefly the screening methodologies for evaluation of antimalarial activity and focuses the activity of alkaloids belonging to different structural classes as well as its importance as new antimalarial drugs or leads and chemical markers for phytomedicines.

show abstract

Antimalarial chemotherapy. Mechanisms of action, resistance, and new directions in drug discovery

Cited by 3 publications

References 0 publications

Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum

Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum

Diagnosis and management of malaria in the intensive care unit

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Contact Info

Product

Resources

About