Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model

Abstract

Interferon-α is used in antiviral therapy

Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia

“…MF even completely disappeared when combining high-dose interferon-a with low-dose cytosine arabinoside. Therefore, an antifibrotic in vivo effect of interferon-a could be ascertained supporting results from animal models and earlier in vitro evaluations [28][29][30] and confirming a recent comparison of interferon-a with chemotherapy on a random basis. 10 The favorable response of MF to the combination of high-dose interferon-a with low-dose cytosine arabinoside, furthermore, is in agreement with superior cytogenetic response rates and prolonged survival of patients observed in two randomized studies comparing this combination with interferon-a monotherapy.…”

“…Indeed, an antifibrotic effect of interferon-a on fibrosis has recently been reported on the basis of BMBs taken prospectively during the course of disease, 10 thus supporting the results from animal models and in vitro studies showing inhibition of procollagen production and fibroblast growth by this cytokine. [28][29][30] However, the possible influences of the interferon dosage and of a combination with cytosine arabinoside have not yet been considered although they may influence the probability of cytogenetic remission. [31][32][33][34] Therefore, BMBs from 200 patients recruited in two prospective therapeutic studies on CML, 16,32,35,36 using different doses of interferon-a with or without cytosine arabinoside, were analyzed with respect to the presence and the evolution of MF.…”

Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

“…Its usefulness for testing antifibrotic drug has been demonstrated (Souza et al 2000(Souza et al , 2001. Several studies have been dedicated to the understanding of the pathogenesis of septal fibrosis.…”

Worm load and septal fibrosis of the liver in Capillaria hepatica-infected rats

“…Souza et al (2000) used the C. hepatica model to study the effect of anti-fibrosis drugs, and also to test the antifibrosing potential of interferon-α (Souza et al 2001). They used inocula of approximately 800 eggs and obtained uniform production of septal fibrosis in all experimental groups.…”