Overview of some biomedical research projects in tropical medicine conducted at the Instituto Venezolano de Investigaciones Cientificas

Romano, Egidio; Cesari, Italo M.; Escalante, Ananías A.; Liprandi, Ferdinando; O'Daly, José A.; Pérez, H.; Takiff, Howard

doi:10.1590/s0074-02762000000700005

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2002

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“…36 Interestingly, a high percentage of the patients with DF (53) were also positive for serotype 2 (serotype 4, 45%; serotype 1, 2%); however, they had higher levels of NO, suggesting that virus serotype is not involved in the increased production of NO. The reason for the basal levels of NO in patients with DHF is not clear to us, but damage of endothelial cells and failure of endothelial NO synthase could be involved.…”

Section: Introductionmentioning

confidence: 98%

Short report: increased level of serum nitric oxide in patients with dengue.

Valero¹,

Espina²,

Áñez³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. Nitric oxide (NO) has been involved in several infectious diseases. Virus dengue is capable of inducing increased levels of NO when cocultured with human Kupffer and spleen cells. However, no reports describe the levels of NO in patients with dengue infection. Increased levels of NO were found in patients with the classic form of the disease; however, in the hemorrhagic form of the disease, similar levels to those of healthy controls were found. In vitro studies showed no increased levels of NO when human platelets were incubated with the virus. Increased NO in classical dengue could be important in the evolution from the nonhemorrhagic to the hemorrhagic forms of dengue.

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Section: Introductionmentioning

confidence: 98%