Characterization of Trypanosoma cruzi

Influence of the long-term Trypanosoma cruzi infection in vertebrate host on the genetic and biological diversity of the parasite

“…The existence of biological and genetic variability in T. cruzi populations has been clearly demonstrated (Marques de Arau´jo and Chiari 1988; Murta and Romanha 1999;Toledo et al 2002). Several studies have Fig.…”

Trypanosoma cruzi I genotype among isolates from patients with chronic Chagas disease followed at the Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ, Brazil)

“…The high genetic variability of T. cruzi has been confirmed by different approaches, and this species was classified in different sub-groups, as zymodemes 6,7,9 , major groups or lineages 10,11 , and thereafter in six discrete typing units (DTUs) 12 , which correspond to the six clusters of isozyme genotypes found by Tibayrenc and Ayala 13 . According to consensus among specialists, the main T. cruzi genetic types were correlated to those six DTUs, and they were renamed Trypanosoma cruzi I-VI (TcI-TcVI) 7,14,15 .…”

Weekly electrocardiographic pattern in mice infected with two different Trypanosoma cruzi strains

“…Initial studies by Miles et al [14] suggested some correlation between Venezuela and Brazil T. cruzi strains and clinical forms, but Apt et al [30] and Breniere et al [12] did not find any relationship between these parameters. On the other hand, Montamat et al [15] observed a correspondence between Z12 parasites A recent study of 45 T. cruzi strains susceptible and naturally resistant to benznidazole and nifurtimox was analyzed by different molecular markers showing that zimodeme B contained exclusively susceptible strains [31].…”