Relevant glycoconjugates on the surface of Trypanosoma cruzi

Colli, Walter; Alves, Maria Júlia M.

doi:10.1590/s0074-02761999000700004

Cited by 36 publications

(20 citation statements)

References 113 publications

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“…Unfortunately, most lineages revealed in the present study lack such obvious synapomorphies due to a high degree of homoplasy across numerous morphological characters previously used for distinguishing individual genera and subfamilies, such as scolex morphology and the position of reproductive organs in relation to the inner longitudinal musculature (Rego 1994, 1999). Thus, the delineation of many taxonomic groups using morphological features remains currently impossible.…”

Section: Discussionmentioning

confidence: 89%

A large 28S rDNA-based phylogeny confirms the limitations of established morphological characters for classification of proteocephalidean tapeworms (Platyhelminthes, Cestoda)

Chambrier¹,

Waeschenbach²,

Fisseha³

et al. 2015

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Proteocephalidean tapeworms form a diverse group of parasites currently known from 315 valid species. Most of the diversity of adult proteocephalideans can be found in freshwater fishes (predominantly catfishes), a large proportion infects reptiles, but only a few infect amphibians, and a single species has been found to parasitize possums. Although they have a cosmopolitan distribution, a large proportion of taxa are exclusively found in South America. We analyzed the largest proteocephalidean cestode molecular dataset to date comprising more than 100 species (30 new), including representatives from 54 genera (80%) and all subfamilies, thus significantly improving upon previous works to develop a molecular phylogeny for the group. The Old World origin of proteocephalideans is confirmed, with their more recent expansion in South America. The earliest diverging lineages are composed of Acanthotaeniinae and Gangesiinae but most of the presently recognized subfamilies (and genera) appear not to be monophyletic; a deep systematic reorganization of the order is thus needed and the present subfamilial system should be abandoned. The main characters on which the classical systematics of the group has been built, such as scolex morphology or relative position of genital organs in relation to the longitudinal musculature, are of limited value, as demonstrated by the very weak support for morphologically-defined subfamilies. However, new characters, such as the pattern of uterus development, relative ovary size, and egg structure have been identified, which may be useful in defining phylogenetically well-supported subgroups. A strongly supported lineage infecting various snakes from a wide geographical distribution was found. Although several improvements over previous works regarding phylogenetic resolution and taxon coverage were achieved in this study, the major polytomy in our tree, composed largely of siluriform parasites from the Neotropics, remained unresolved and possibly reflects a rapid radiation. The genus Spasskyellina Freze, 1965 is resurrected for three species of Monticellia bearing spinitriches on the margins of their suckers.

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Section: Discussionmentioning

confidence: 89%

A large 28S rDNA-based phylogeny confirms the limitations of established morphological characters for classification of proteocephalidean tapeworms (Platyhelminthes, Cestoda)

Chambrier¹,

Waeschenbach²,

Fisseha³

et al. 2015

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“…They all have been implicated in host-cell attachment and invasion [62, 92–94]. These proteins have complete or degenerate Asp box motifs (SxDxGxTW); the VTVxNVxLYNR motif characteristic of all TS members; and a signal sequence for cleavage/addition of GPI anchor at the C-terminal region (Figure 3) [60, 62, 95].…”

Section: Trans-sialidase Superfamilymentioning

confidence: 99%

A Brief View of the Surface Membrane Proteins fromTrypanosoma cruzi

Pech-Canul

Monteón

Solís-Oviedo

2017

Journal of Parasitology Research

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Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people around the world mostly in Central and South America. T. cruzi expresses a wide variety of proteins on its surface membrane which has an important role in the biology of these parasites. Surface molecules of the parasites are the result of the environment to which the parasites are exposed during their life cycle. Hence, T. cruzi displays several modifications when they move from one host to another. Due to the complexity of this parasite's cell surface, this review presents some membrane proteins organized as large families, as they are the most abundant and/or relevant throughout the T. cruzi membrane.

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“…Sugar residues on the surface of cells, generally components of glycoproteins or glycolipids, are valuable markers for discriminating between distinct cell populations of similar morphology (Nakamura et al 1992). Additionally, cumulative evidence indicates that, in trypanosomatids, glycoconjugates are relevant in several phases of host-parasite interactions such as cellular recognition, adhesion, penetration, survival within host cells, and cell antigenicity (De Souza 1995;Colli and Alves 1999;Descoteaux and Turco 1999).…”

Section: Introductionmentioning

confidence: 99%

Changes of sialomolecules during the dimethylsulfoxide-induced differentiation of Herpetomonas samuelpessoai

Santos¹,

Rodrigues

Alviano³

et al. 2002

Parasitology Research

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The expression of sialoglycoconjugates during the dimethylsulfoxide (DMSO)-induced differentiation of Herpetomonas samuelpessoai was analyzed by flow cytometry and Western blotting using sialic acid-specific lectins. Parasites reacted strongly with Limax flavus (LFA) and Sambucus nigra (SNA) agglutinins, and only weakly with Maackia amurensis (MAA) lectin. However, analysis of crude protein extracts by Western blotting revealed that bands with molecular masses corresponding to 15 and 40 kDa are recognized by MAA, and that treatment with DMSO induced the expression of two additional polypeptides with molecular masses of 65 and 90 kDa. Profiles of binding to LFA were indistinguishable when protein extracts from control or differentiated cells were analyzed. SNA recognized a major molecule with 25 kDa in extracts from non-differentiated forms and two low-molecular-weight bands from differentiated cells. These results indicate that molecules containing alpha2,6 and alpha2,3 sialyl-galactosyl sequences are present in H. samuelpessoai, and that their biosynthesis and expression are influenced by DMSO-induced differentiation.

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Relevant glycoconjugates on the surface of Trypanosoma cruzi

Cited by 36 publications

References 113 publications

A large 28S rDNA-based phylogeny confirms the limitations of established morphological characters for classification of proteocephalidean tapeworms (Platyhelminthes, Cestoda)

A large 28S rDNA-based phylogeny confirms the limitations of established morphological characters for classification of proteocephalidean tapeworms (Platyhelminthes, Cestoda)

A Brief View of the Surface Membrane Proteins fromTrypanosoma cruzi

Changes of sialomolecules during the dimethylsulfoxide-induced differentiation of Herpetomonas samuelpessoai

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