Efficacy of a new schistosomicidal agent 2-[(methylpropyl)amino]-1-octanethiosulfuric acid against an oxamniquine resistant Schistosoma mansoni isolate

In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms

“…Reduced cure rates and the failure of treatment after PZQ administration have been reported in patients (Botros et al 2003). In addition, the existence of resistant strains reinforces the need to develop new safe and effective schistosomicidal drugs (Penido et al 1999;Ribeiro-dosSantos et al 2006).…”

The Use of Brazilian Medicinal Plants to Combat Schistosoma mansoni

“…Still in 1976, Nelson and Pellegrino (1976) described the schistosomicidal activity of alkylaminoalkanethio-sulfuric acids for the first time. Preclinical assays with S. mansoni provided evidence of preferential activity against adult females (Penido et al, 1999), but so far no clinical assays have been carried out. In 1978, screening of benzodiazepine derivatives showed that some of the compounds of this group have strong schistosomicidal activity, in particular (+)-5-(-o-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepine-2-one, which was named Ro 11-3128 www.intechopen.com (Stohler, 1978).…”

Antibody reactivity against potato apyrase, a protein that shares epitopes with Schistosoma mansoni ATP diphosphohydrolase isoforms, in acute and chronically infected mice, after chemotherapy and reinfection

“…For chemotherapy, on day 127 post-infection, infected and uninfected mice were treated with a single dose of oxamniquine (400 mg/Kg body weight) (Penido et al 1999) by an oral route. Serum samples were obtained at four and 11 months after treatment (mAT).…”