Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines

Lima, Valdirene S.; Mangia, Regina Helena Riccioppo; Carreira, João Carlos Araújo; Marchewski, Renato S; Jansen, Ana Maria

doi:10.1590/s0074-02761999000300021

Cited by 8 publications

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References 19 publications

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“…Comparing two fresh isolates, both originating from T. vitticeps, one isolate infected 61% and the other one 39% of T. infestans (Kollien et al 1998). Clone or strain specificities are indicated not only by different numbers of parasites in the gut but also by different percentages of metacyclic trypomastigotes (e.g., Perlowagora-Szumlewicz et al 1990;Perlowagora-Szumlewicz and Moreira 1994;Alvarenga and Bronfen 1997;Pinto et al 1998;Lana et al 1998;Lima et al 1999). Using two T. cruzi strains from the same locality and T. infestans also originating from there, the number of metacyclics differed strongly .…”

Section: Disadvantages Of Xenodiagnosis Of Chagas Disease: Sensitivitymentioning

confidence: 99%

Xenodiagnosis

Meiser¹,

Schaub²

2011

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In xenodiagnosis, the vector of a pathogenic agent is infected to make identification of the parasite easier after a period of multiplications. This enables a diagnosis if the strain of the pathogen possesses a low virulence or if very low numbers of parasites occur in the blood, for example Trypanosoma cruzi in the chronic phase of Chagas disease. In 1914, 5 years after the discovery of T. cruzi in the triatomines, its blood-sucking vectors, these were used for the first time as a diagnostic tool of this disease. For many decades thereafter xenodiagnosis represented the golden standard. Meanwhile serological and molecular biological methods are preferably used for diagnosis today, but xenodiagnosis and in vitro cultivation are still the best methods for a proof of the living parasites or for the isolation of the flagellate. In this context, the different methodological variations and the disadvantages and advantages of xenodiagnosis are discussed in our review.

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