A New Enzymatic Variant of Leishmania (Leishmania) forattinii Isolated from Proechimys iheringi (Rodentia, Echimydae) in Espírirto Santo, Brazil

Falqueto, Aloísio; Cupolillo, Elisa; Machado, Gerzia Maria C.; Carvalho-Paes, Luiz Eduardo de; Grimaldi, Gabriel

doi:10.1590/s0074-02761998000600017

Cited by 6 publications

(6 citation statements)

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“…Furthermore, the role of the opossum in SCHALLIG ET AL. 390 disease transmission can also be little, as some of the species found in Didelphis or other animals are most likely not transmitted to humans (Falqueto et al 1998). On the other hand, the presence of parasites causing severe disease is a concern.…”

Section: Discussionmentioning

confidence: 99%

Didelphis marsupialis(Common Opossum): A Potential Reservoir Host for Zoonotic Leishmaniasis in the Metropolitan Region of Belo Horizonte (Minas Gerais, Brazil)

Schallig

Silva

Meide

et al. 2007

Vector-Borne and Zoonotic Diseases

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Identification of the zoonotic reservoir is important for leishmaniasis control program. A number of (wild) animal species may serve as reservoir hosts, including the opossum Didelphis marsupialis. A survey carried out in Didelphis specimens (n = 111) from the metropolitan region of Belo Horizonte, an important focus of human leishmaniasis in Brazil, is reported. All animals were serologically tested with indirect fluorescence antibody test (IFAT) and direct agglutination tests (DAT) based on L. (L.) donovani or L. (V.) braziliensis antigen. A sub-population (n = 20) was analyzed with polymerase chain reaction (PCR) for the presence of Leishmania-specific DNA. For species identification, PCR-positive samples were subjected to restriction enzyme fragment polymorphism (RFLP) analysis. Depending on the sero-diagnostic test employed, the sero-prevalence varied between 8.1% (9/111 animals positive with DAT test based on L. braziliensis antigen) and 21.6% (24/111 animals positive with IFAT). Five out of 20 samples analyzed with PCR tested positive for the presence of Leishmania-specific DNA. RFLP analysis revealed that two samples contained L. braziliensis complex DNA, one contained L. donovani complex DNA, and two samples could not be typed with the methodology used. These data suggest a potential role for the opossum as a reservoir host for zoonotic leishmaniasis in the region.

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Section: Discussionmentioning

confidence: 99%

Didelphis marsupialis(Common Opossum): A Potential Reservoir Host for Zoonotic Leishmaniasis in the Metropolitan Region of Belo Horizonte (Minas Gerais, Brazil)

Schallig

Silva

Meide

et al. 2007

Vector-Borne and Zoonotic Diseases

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“…L. (L.) chagasi associa-ted with visceral leishmaniasis (VL) in humans and dogs has also been recorded in the state (Grimaldi et al 1989). Natural infections of spiny-rats (Proechimys iheringi) were detected in a secondary forest located in the municipality of Viana, but the three isolates were identified as a new enzymatic variant of L. (L.) forattinii (Falqueto et al 1998), probably transmitted by Lutzomyia gasparviannai .…”

Section: Epidemiological and Clinical Features Of Leishmania (Vianniamentioning

confidence: 99%

Epidemiological and clinical features of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in the State of Espírito Santo, Brazil

Falqueto¹,

Sessa²,

Ferreira³

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…These could either be domestic, such as cats [23] and horses [24], or part of the wild life in a so-called sylvatic cycle. In particular in South and Central America, not only Leishmania species are known to affect humans, but sylvatic species such as L. forattinii , L. enrietti , and L. deanei have been encountered in wild animals such as tree-porcupines [25], foxes ( Dusicyon vetulus and Cerdocyon thous ) [26, 27], rodents [28, 29], and opossums ( Didelphis marsupialis ) [30–32]. Future studies on incriminating possible reservoirs for leishmaniasis in Suriname should therefore also consider the fauna of the interior.…”

Section: Discussionmentioning

confidence: 99%

Is the Dog a Possible Reservoir for Cutaneous Leishmaniasis in Suriname?

Kent

Ramkalup²,

Mans

et al. 2013

Journal of Tropical Medicine

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Cutaneous leishmaniasis (CL) is an emerging disease in Suriname, with at least 200 cases per year. Little is known about the biology of CL in the country. The most important parasite species is Leishmania Viannia guyanensis, but possible vectors and reservoirs are hardly incriminated. In the present study, it was investigated whether the dog could possibly be a zoonotic reservoir for the disease in Suriname. Forty-seven dogs were examined for overt clinical signs of leishmaniasis, and blood samples were collected on filter paper for serology (direct agglutination test) and molecular biology (by polymerase chain reaction). Three dogs had clinical signs that could be compatible with canine cutaneous leishmaniosis: dermatitis (two) or nasal lesion (one). Two dogs were seropositive with DAT (titre > 1 : 1600), and three animals had a borderline titre (1 : 800). All other animals (n = 42) were DAT negative. PCR analysis found Leishmania DNA equivalent to 1 parasite per mL in only one dog at a first round of analysis, but this animal was negative after retesting. The clinical, serological, and molecular data show some preliminary lines of evidence that canine leishmaniosis is present in Suriname, but further studies are needed to incriminate the reservoir, including a possible sylvatic cycle.

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A New Enzymatic Variant of Leishmania (Leishmania) forattinii Isolated from Proechimys iheringi (Rodentia, Echimydae) in Espírirto Santo, Brazil

Cited by 6 publications

References 0 publications

Didelphis marsupialis(Common Opossum): A Potential Reservoir Host for Zoonotic Leishmaniasis in the Metropolitan Region of Belo Horizonte (Minas Gerais, Brazil)

Didelphis marsupialis(Common Opossum): A Potential Reservoir Host for Zoonotic Leishmaniasis in the Metropolitan Region of Belo Horizonte (Minas Gerais, Brazil)

Epidemiological and clinical features of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in the State of Espírito Santo, Brazil

Is the Dog a Possible Reservoir for Cutaneous Leishmaniasis in Suriname?

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