Study on the Elimination of Angiostrongylus costaricensis First Stage Larvae in the Experimental Infection of Swiss Mice

Canali, Cibele; Goulart, Aline Hamilton; Graeff-Teixeira, Carlos

doi:10.1590/s0074-02761998000200026

Cited by 6 publications

(9 citation statements)

References 8 publications

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“…This is in agreement with other studies, which have described high rates of mortality in M. musculus and Swiss mice experimentally infected with A. costaricensis (Canali et al 1998;dos Santos et al 1996). We emphasize that Swiss mice has been considered a suitable animal model for studying angiostrongyliasis.…”

Section: Discussionsupporting

confidence: 93%

“…1 Correlation between L1 count in feces and survival (n=12) consumption, physical activity, and defecation at this period. In agreement with the literature (Canali et al 1998), we observed a huge variation in the amount of L1 eliminated in feces in both inter-and intra-subject comparisons. This was also observed when comparing diurnal and nocturnal periods.…”

Section: Discussionsupporting

confidence: 92%

“…Canali et al (1998) studied A. costaricensis in domestic mouse Mus musculus and found a substantial variation in daily elimination of L1 in feces.…”

Section: Introductionmentioning

confidence: 99%

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Elimination of Angiostrongylus costaricensis larvae in feces from experimentally infected Swiss mice: circadian rhythm and correlation with survival

et al. 2010

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Angiostrongylus costaricensis is a nematode which harbors mesentery arteries of rodents. In these animals, a circadian rhythm of elimination of first-stage larvae (L1) and a relation between the amount of L1 in feces and survival are unknown. We assessed fecal elimination of A. costaricensis L1 from experimentally infected Swiss mice and tried to correlate L1 elimination with survival. Thirteen Swiss mice were infected by gavage with ten A. costaricensis L3 larvae obtained from Phyllocaulis slugs. Feces were weighed at 7 A.M: . and 7 P.M: . starting from the 24th day post-infection until animal death. Feces sediment was examined in microscope for L1 counting. The mice were dead after a period ranging 19-61 days post-infection. Compared to diurnal samples, both feces' weight (2.3 ± 0.7 vs. 1.8 ± 0.5 g; P < 0.0001) and L1 total count [median 1,950 vs. 1,250; P = 0.015] were higher in feces eliminated at night. No difference was observed between diurnal and nocturnal elimination when counting L1 by gram of feces (725 vs. 650 L1/g; P = 0.821). A significant correlation was observed between survival and total number of L1 in feces (r = 0.84; P = 0.0007). This study suggests that mice experimentally infected with A. costaricensis eliminate more L1 at night due to higher fecal volume at this period. The correlation between number of L1 in feces and survival suggests a phenomenon of tolerance to A. costaricensis infection in mice with longer survival.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

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Elimination of Angiostrongylus costaricensis larvae in feces from experimentally infected Swiss mice: circadian rhythm and correlation with survival

et al. 2010

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“…Similar results with an enormous variation in the excretion of L1 and a high mortality have been reported by Canali et al (1999) for Swiss mice. These authors considered their observations to be an indication of how little adaptation between the parasite and the murine host was present, and they concluded that Mus musculus does not play an important role in the natural parasite life cycle and epidemiology of the disease.…”

Section: Discussionsupporting

confidence: 88%

Long-term observations on mouse strains experimentally infected with Angiostrongylus costaricensis

et al. 2004

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BALB/c and C57BL/6 mice were experimentally infected with Angiostrongylus costaricensis and the parasitic parameters and antibody response during the acute and chronic phases of infection were analyzed. Following administration of six third-stage larvae (L3), there was no significant difference in the mean worm recovery or mean larval output. Coinciding with the maturation of worms in infected animals and with the egg output in mesenteric arteries, a strong increase in the humoral immune response was observed in both mouse strains. This response was characterized by a hypergammaglobulinemia, with a predominance of IgA and IgG1 during the acute phase of infection, and IgG1 and total IgE during the patent and post-patent periods. Significantly higher levels of IgM, IgG and IgG1 were found in BALB/c mice compared with C57BL/6 mice. On the other hand, a significantly higher concentration of IgA was detected at 6 and 7 weeks post-infection in C57BL/6 mice compared with BALB/c mice. Specific IgE could not be detected in any of the mouse strains. Our results suggest that immunoglobulins, mainly IgG1, contribute to the outcome of a primary A. costaricensis infection with respect to the period of patency and to mortality during the chronic phase.

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“…The adult worm lives inside the mesenteric arteries or its branches and may accidentally infect man 1 . There is a report from Costa Rica of a natural infection of Canis familiaris with intestinal lesions similar to those described in humans 2 . For this reason a preliminar experiment was planned to evaluate the usefullness of dogs as an experimental model for pathological studies on abdominal angiostrongyliasis.…”

Section: Abstract: Metastrongyloidea; Angiostrongylus Costaricensis; mentioning

confidence: 59%

dogs may be a reservoir host for Angiostrongylus costaricensis

Rodriguez

Agostini

Porto

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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Angiostrongylus costaricensis is a parasitic nematode of wild rodents. Several other vertebrate species including man may become infected by ingestion of the third stage larvae produced by the intermediate hosts, usually slugs from the family Veronicellidae. There is a report of the diagnosis of abdominal angiostrongyliasis in Canis familiaris with lesions resembling those found in human disease. As a preliminar evaluation of the adequacy of a canine model for pathogenetic studies, a dog was inoculated with 75 L3 of A. costaricensis. Infection was established and fist stage larvae were found in feces up to 88 days post infection, sometimes in very large numbers (9.5 x 10(4) L1/g). No clinical manifestations or significant lesions were detected. These are indications that dog may play a role as a reservoir host for A. costaricensis.

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Study on the Elimination of Angiostrongylus costaricensis First Stage Larvae in the Experimental Infection of Swiss Mice

Abstract: Abdominal angiostrongylosis is a nematode infection of wild rodents. Human infection may result in

Cited by 6 publications

References 8 publications

Elimination of Angiostrongylus costaricensis larvae in feces from experimentally infected Swiss mice: circadian rhythm and correlation with survival

Elimination of Angiostrongylus costaricensis larvae in feces from experimentally infected Swiss mice: circadian rhythm and correlation with survival

Long-term observations on mouse strains experimentally infected with Angiostrongylus costaricensis

dogs may be a reservoir host for Angiostrongylus costaricensis

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