Differential Regulation of Granuloma Size and Hepatic Fibrosis in Schistosome Infections

Cheever, Allen W.

doi:10.1590/s0074-02761997000500024

Cited by 20 publications

(21 citation statements)

References 23 publications

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“…larger granulomas are not always associated with greater hepatic fibrosis (Olds et al 1989, Cheever et al 1994c, Phillips et al 1996, Cheever 1997, Chiramonte et al 1999b, Fallon et al 2000b). Hepatic fibrosis in schistosome infected mice is clearly linked to IL-13 and the Th2 response, although fibrosis also clearly sometimes occurs around granulomas formed in the Th1 melieu (Chen & Boros 1999, Hoffmann et al 2000, Hesse et al 2000.…”

Section: Generalmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

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121

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Section: Generalmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

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121

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“…The regulation of fibrosis in the liver may differ from the regulation of granuloma size (Olds et al 1989, Phillips et al 1996, Cheever 1997. In addition, the absence of regulatory idiotypes correlated with the development of pipestem portal fibrosis (a qualitative microscopic assessment) in mice but not with altered regulation of granuloma size (Henderson et al 1993).…”

Section: Are There Different Types/mechanisms Of Immunologic Regulatimentioning

confidence: 99%

“…Downmodulation of granuloma size in the liver may differ from regulation of granuloma size in the gut (Weinstock & Boros 1981) or lungs (Souza Vidal et al 1993) of infected mice and regulation of hepatic fibrosis frequently differs from that of hepatic granuloma size (Olds et al 1989, Cheever 1997.…”

Section: Are There Different Types/mechanisms Of Immunologic Regulatimentioning

confidence: 99%

Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice

Cheever

Janković²,

Yap³

et al. 1998

Mem. Inst. Oswaldo Cruz

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Variations in the size of granulomas in acute (8 week) infections may be influenced primarily by the number and state of activation of T cells. In chronic (12-16 week) infections immunologic downmodulation proceeded normally in mice without functional CD8+ cells and in IFN-g KO mice but not in B cell KO (mMT) mice or in mice deficient in FcR expression in spite of the fact that these mice downregulated their T cell and cytokine responses. It is evident that the participation of cytokines in granuloma formation and regulation is complicated and that the mechanisms controlling both these phenomena are likely to involve both T cells and antibody/FcR interactions.

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“…In contrast, in chronic infections, downregulation of granuloma size requires an antibody and downmodulated T cells (8). The regulation of fibrosis in the liver may differ from the regulation of granuloma size (7,(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers

Lenzi

Kimmel

Schechtman

et al. 1999

Braz J Med Biol Res

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The collagen structure of isolated and in situ liver granuloma from Swiss Webster mice infected with Schistosoma mansoni was sequentially and three-dimensionally analyzed during different times of infection (early acute, acute, transitional acute-chronic, and chronic phases) by laser scanning confocal microscopy and electron scanning variable vacuum microscopy. The initial granuloma structure is characterized by vascular collagen residues and by anchorage points (or fiber radiation centers), from where collagenous fibers are angularly shed and self-assembled. During the exudative-productive stage, the self-assembly of these fibers minimizes energy and mass through continuous tension and focal compression. The curvature or angles between collagen fibers probably depends on the fibroblastic or myofibroblastic organization of stress fibers. Gradually, the loose unstable lattice of the exudative-productive stage transforms into a highly packed and stable architecture as a result of progressive compactness. The three-dimensional architecture of granulomas provides increased tissue integrity, efficient distribution of soluble compounds and a haptotactic background to the cells.

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Differential Regulation of Granuloma Size and Hepatic Fibrosis in Schistosome Infections

Cited by 20 publications

References 23 publications

Experimental models of Schistosoma mansoni infection

Experimental models of Schistosoma mansoni infection

Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice

Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers

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