The immunopathology of human schistosomiasis-III: immunoglobulin isotype profiles and response to praziquantel

Ramirez, R; Ceballos, E; Noya, Belkisyolé Alarcón de; Noya, Óscar; Bianco, N. E.

doi:10.1590/s0074-02761996000500010

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…In elements of complement system C 3 and C 4, there is a significant decrease in level of C 4 in pregnant subjects with sym UTI in comparison to subjects without sym UTI and any significant result is not observed in level of C 3 and C 4 between pregnant and non-pregnant with sym bacteriuria. The present study showed elevated levels of IgG in sym UTI subjects, both pregnant and non-pregnant women, others have documented similar observation in their studies about protective immunity against parasite [32], [33], [34] and its level has been shown to correlate with the intensity of infection [35]. The protective role of IgG against pathogens could explain the significantly high serum IgG found in symUTI subjects in the present study, since it is the immunoglobulin secreted during secondary immune response.…”

Section: Immunological Study:-supporting

confidence: 88%

Immunoligical study among pregnant and non-pregnant women with symptomatic and asymptomatic Urinary tract infection in Kirkuk city-Iraq

Abbas¹,

Shareef²,

Jabbar³

2013

J.Edu.Sci.

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Immunoligical study among pregnant and non-pregnant women with ... 69‫رضي‬ ‫ال‬ ‫تالحاالت‬ ‫نة‬ ‫مشار‬ ‫ة‬ ‫امن‬ ‫الحو‬ ‫النساا‬ ‫ن‬ ‫التوليه‬ ‫المجار‬ ‫اللتباتات‬ ‫أابرت‬ ‫الحاالت‬ ‫ـه‬ ‫عالي‬ ‫ـتويات‬ ‫مس‬ ‫ـيه‬ ‫اض‬ ‫الالاعر‬ ‫ـخ‬ ‫م‬ ‫ـن‬ ‫ك‬ ‫ـخ‬ ‫م‬ IgG ‫و‬ IgM ‫و‬ C3 ‫و‬ C4 ‫ل‬ ‫ـدت‬ ‫وج‬ ‫ـا‬ ‫تينم‬ IgA ‫ـي‬ ‫ـ‬ ‫رض‬ ‫ال‬ ‫ـاالت‬ ‫ـ‬ ‫الح‬ ‫ـن‬ ‫ـ‬ ‫ـه‬ ‫ـ‬ ‫عالي‬ ‫ة‬ ‫ـتنتجت‬ ‫ـ‬ ‫اس‬ : ‫ـتنتا‬ ‫ـ‬ ‫االس‬ . ‫ـة‬ ‫ـ‬ ‫اس‬ ‫الدر‬ ‫ـة‬ ‫ـ‬ ‫الحالي‬ ‫ـه‬ ‫ـ‬ ‫التولي‬ ‫ـار‬ ‫ـ‬ ‫المج‬ ‫ـات‬ ‫ـ‬ ‫التبات‬ ‫اخ‬ ‫ـاهر‬ ‫ما‬ ‫ـ‬ ‫مخت‬ ‫ـخ‬ ‫م‬ ‫ـر‬ ‫ي‬ ‫ت‬ ‫سد‬ ‫الحمن‬ ‫و‬ ‫ـة‬ ‫المناع‬ ‫ـ‬ ‫طي‬ ‫الخ‬ ‫ة‬ ‫ـدهما‬ ‫اح‬ ‫ـدهر‬ ‫ي‬ ‫ـا‬ ‫تم‬ ‫ر‬ ‫ـا‬ ‫م‬ ‫ـدهما‬ ‫اج‬ ‫تو‬ ‫ـاخ‬ ‫ـذا‬ ‫ل‬ ‫ل‬ ‫ع‬ ‫ايخر‬ . AbstractIn this study an attempt was carried out to: estimate the: 1prevalence of asymptomatic bacteriuria in pregnancy, its causative agents and their sensitivity pattern in Kirkuk city.2-Role of humoral immune response in women with symptomatic and a symptomatic urinary tract infection through the measuring of IgG,IgA, IgM,C 3 and C 4 levels in urine and serum of patients and comparing them with corresponding levels of healthy control groups.The results showed that the prevalence of asymptomatic (UTI) in pregnancy was (10%). E.coli was the commonest causative bacteria in both pregnant and non-pregnant with symptomatic and a symptomatic (UTI).The antibiotic ciprofloxacin, ceftriaxone and gentamicin was the most effectiveRegarding the immunological study: pregnant and non-pregnant subjects with symptomatic (UTI) showed significant increase in the level of IgG and IgA and no significant differences was noticed in the level of IgM as compared with control group. Significant differences between pregnant and non-pregnant subjects with symptomatic (UTI) was observed only in the level of IgM.Pregnant subjects with symptomatic (UTI) showed a significant decrease in the level of C 4 as compared to control group, any significant differences were not observed between pregnant and non-pregnant in the level of C 3 and C 4 .Compared to symptomatic (UTI) in pregnant subject asymptomatic (UTI) subjects recorded the highest serum levels of IgG,IgM, C 3 andC 4, while the highest values of IgA was found in symptomatic UTI. Conclusion:-Bacteriuria or pregnancy changes different aspects of humoral immunity, thus the co-existence of pregnancy and bacteriuria may influence each other.

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Section: Immunological Study:-supporting

confidence: 88%

Immunoligical study among pregnant and non-pregnant women with symptomatic and asymptomatic Urinary tract infection in Kirkuk city-Iraq

Abbas¹,

Shareef²,

Jabbar³

2013

J.Edu.Sci.

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“…Helminth infections, as reconfirmed in this study, are well known to be associated with high IgE levels. [19][20][21] Basophils bind IgE through high-affinity receptors on their surface and degranulate and release histamine and other inflammatory mediators after cross-linking of these receptors. 22 Basophils from Toxocara-, Ascaris-, Onchocerca-, Wuchereria-, Strongyloides-, and Schistosoma-infected patients have been shown to release histamine in response to parasite antigen.…”

Section: Discussionmentioning

confidence: 99%

Lack of Basophilia in Human Parasitic Infections

Mitre¹,

Nutman²

2003

The American Journal of Tropical Medicine and Hygiene

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While basophilia is often found in animal models of parasitic infection, it has not yet been established whether it occurs in parasite-infected humans. We investigated the relationship between basophilia and parasitic infections in humans by reviewing charts from 668 patients with confirmed parasitic infection (472 with only helminths, 146 with only protozoa, and 50 with both helminth and protozoan infections) and from 50 patients without parasitic infections. Basophilia (> 290 cells/mm3) occurred in only four of the 668 parasite-infected patients (0.6%), and there were no statistically significant differences in the percentages of patients with basophilia or in the absolute basophil counts among either the helminth-infected, protozoa-infected, or uninfected populations. Analysis with regard to relative basophil levels revealed that basophils constituted more than 3% of the peripheral white blood cell population in only four patients. Thus, basophilia occurs only rarely in human parasitic infections and is consequently not a useful clinical marker in the evaluation of suspected parasitic disease. * Statistically greater than frequency in protozoa only patients and in uninfected patients (P < 0.0001). † Statistically greater than frequency in uninfected patients (P < 0.001).

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“…[1][2][3] In contrast to bacterial, viral, and protozoan infections, the human immune response to helminths is characterized by elevated serum levels of antigen-specific and polyclonal IgE. [4][5][6] Indeed, antigen-specific IgE has been shown to be an important component of protective immunity in multiple animal models of helminth infection [7][8][9] and to be associated with decreased rates of helminth infection in human beings. [10][11][12] Although several studies have examined the duration of antigen-specific IgE responses in allergy, [13][14][15][16] there have been only 2 longitudinal studies quantifying parasitespecific IgE levels after helminth infection.…”

mentioning

confidence: 99%

IgE memory: Persistence of antigen-specific IgE responses years after treatment of human filarial infections

Mitre¹,

Nutman²

2006

Journal of Allergy and Clinical Immunology

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The immunopathology of human schistosomiasis-III: immunoglobulin isotype profiles and response to praziquantel

Abstract: Immunoglobulin (Ig)

Cited by 10 publications

References 39 publications

Immunoligical study among pregnant and non-pregnant women with symptomatic and asymptomatic Urinary tract infection in Kirkuk city-Iraq

Immunoligical study among pregnant and non-pregnant women with symptomatic and asymptomatic Urinary tract infection in Kirkuk city-Iraq

Lack of Basophilia in Human Parasitic Infections

IgE memory: Persistence of antigen-specific IgE responses years after treatment of human filarial infections

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