Co-Infection with HIV and Mycobacterium tuberculosis: immunologic interactions, disease progression, and survival

Ho, John L.

doi:10.1590/s0074-02761996000300025

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Most patients with HIV/TB co-infection had not been exposed to TB carriers previously. We suggest that active TB is a result of either fast primary progression of a recent infection or reactivation of a latent infection, a conclusion also reached by Ho [20].…”

Section: Discussionsupporting

confidence: 69%

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital

Carvalho¹,

Monteiro²,

Neto³

et al. 2008

Braz J Infect Dis

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Infection with both Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis is currently the world's leading cause of death due to infectious agents. We evaluated factors related to the development of tuberculosis (TB) in HIV-infected patients who were being treated at an infectious diseases hospital in Fortaleza, Ceará, Brazil. From January 2004 to December 2005, we made an epidemiological study through the analysis of the medical records of 171 patients, who were diagnosed as having both HIV and tuberculosis. Among these co-infected patients, most (81%, p=0.0006) were male. Co-infection was more frequent (87.8%) among patients over 40 years of age and those with lower educational levels (less than eight years of schooling). Forty-one percent of the patients in the study had not had a smear culture test for acid-fast bacilli (AFB). CD4 cell counts were lower than 200 cells/µ µ µ µ µL in 71.9% of the patients, the mean being 169 cells/µ µ µ µ µL. This type of data is important for establishing strategies to improve the control of tuberculosis in HIV-infected patients.

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Section: Discussionsupporting

confidence: 69%

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital

Carvalho¹,

Monteiro²,

Neto³

et al. 2008

Braz J Infect Dis

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“…This is worsened when there is TB coinfection where all blood cell lineages are involved [4, 11]. These often pose a great challenge in the comprehensive management such as cytopenias, anemia, and neutropenia which are caused by inadequate production of cells because of suppression of the bone marrow by the HIV infection through abnormal cytokine expression and alteration of bone marrow microenvironment [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Hematological Abnormalities of Pulmonary Tuberculosis Patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study

Abay

Yalew

Shibabaw

et al. 2018

Tuberculosis Research and Treatment

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Background Hematological abnormalities are common in pulmonary tuberculosis (PTB) patients, which is one of the major public health problems worldwide. However, there is paucity of information about the hematological profile of PTB patients with and without HIV in the study area. Therefore, this study aimed to assess hematological abnormalities of pulmonary tuberculosis patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia. Methods A comparative cross-sectional study was conducted at the University of Gondar Hospital. Sociodemographic data was collected using a pretested, structured questionnaire. Five milliliters of venous blood sample was collected and divided into a 3 ml EDTA tube for complete blood count with the Cell Dyn 1800 hematological analyzer and a 2 ml citrated tube for erythrocyte sedimentation rate determination. Data were entered into Epi Info version 3.5.3 and then transferred to SPSS 20 for analysis. The independent samples t-test was used to compare the mean values of hematological parameters between PTB patients and PTB-HIV coinfected patients. Result A total of 100 study subjects (50 PTB and 50 PTB-HIV coinfected) were included with a mean age of 31.3 ± 10.3 years for PTB patients and 32.1 ± 9.2 years for PTB-HIV coinfected patients. In this study, there were significantly lower mean values of Hgb (P = 0.049), platelet count (P < 0.001), and neutrophils counts (P = 0.007) among PTB-HIV coinfected patients when compared with PTB patients. Of the PTB infected patients 46% were anemic, 6% leukopenic, 22% neutropenic, 8% lymphopenic, and 8% thrombocytopenic. On the other hand, of the PTB-HIV coinfected patients 60% were anemic, 14% leukopenic, 66% neutropenic, 12% lymphopenic, and 20% thrombocytopenic. ESR value was increased in all patients. Conclusion This study demonstrated high prevalence of neutropenia, anemia, and thrombocytopenia among PTB-HIV coinfected patients. HIV coinfection worsens hematological abnormalities of PTB patients. Assessment of hematological parameters can be used as an indicator in the diagnosis and follow-up of PTB patients coinfected with HIV. We recommended assessment of PTB patients with or without HIV for various hematological disorders such as neutropenia, anemia, and thrombocytopenia.

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“…HIV infection increases the risk of developing active TBC, either from reactivation of latent infection or rapid progression of newly ac-quired infection and co-infection can enhance HIV replication, thereby shortening survival and potentially enhance HIV transmission (Ho 1996).…”

mentioning

confidence: 99%

Comparison between Human Immunodeficiency Virus Positive and Negative Patients with Tuberculosis in Southern Brazil

Henn

Nagel

Dal‐Pizzol

1999

Mem. Inst. Oswaldo Cruz

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Co-Infection with HIV and Mycobacterium tuberculosis: immunologic interactions, disease progression, and survival

Cited by 4 publications

References 19 publications

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital

Hematological Abnormalities of Pulmonary Tuberculosis Patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study

Comparison between Human Immunodeficiency Virus Positive and Negative Patients with Tuberculosis in Southern Brazil

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