Use of the 2,3-diacyl-trehalose and the purified protein derivative in the serodiagnosis of tuberculosis in AIDS

Abstract

The effect of the human immunodeficiency virus (HIV) infection on IgG production against purified protein derivative (PPD) and 2,

Improved diagnosis of tuberculosis in HIV-positive patients using RD1-encoded antigen CFP-10

“…The routine diagnostic methods for TB (smear and X-ray) are not ideal for use in HIV-TB, due to lower sensitivity and nonspecificity. Serologic diagnostic tests using crude mycobacterial antigens such as culture filtrate antigen (CFA), PPD, and antigen A60, 10,11 as well as purified lipid antigens [21][22][23][24] and protein antigens, [6][7][8][9] have been tried with varying results. Among the available purified protein antigens, 38-kDa and its epitopes have been well studied due to their specificity.…”