Assessment of immunity induced in mice by glycoproteins derived from different strains and species of Leishmania

Guimarães, Talita Antunes; Toledo, Vicente de Paulo Coelho Peixoto de; Costa, Carlos Alberto da; Costa, Rosane Dias; Genaro, Odair; Williams, Paul; Mayrink, Wilson

doi:10.1590/s0074-02761996000100010

Cited by 9 publications

(2 citation statements)

References 34 publications

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“…While a few polypeptides, including the dominant 62-to 64-kDa polypeptide, demonstrated seroreactivity in neutral and positively charged liposomes, a larger number were seroreactive in association with negatively charged vesicles, with antisera obtained through the corre- (37), and its role in induction of protection against murine cutaneous leishmaniasis has been extensively investigated (25,51,64). The subjects of the studies range from the use of the native protein (13,16,51) to the use of recombinant gp63 (rgp63) expressed in Salmonella spp. (64) or plasmid pCMV, which encodes gp63 (62), to the use of T-cell epitopes within gp63 (25,63).…”

Section: Discussionmentioning

confidence: 99%

Characterization ofLeishmania donovaniAntigens Encapsulated in Liposomes That Induce Protective Immunity in BALB/c Mice

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Characterization ofLeishmania donovaniAntigens Encapsulated in Liposomes That Induce Protective Immunity in BALB/c Mice

et al. 2002

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“…Absorbance was determined in an automatic ELISA reader at 492 nm. A sample with gp63 kDa was considered preserved when the average absorbance was equal or higher than 0.500 (Guimarães et al, 1996).…”

Section: Study Of Gp63 Kda Stabilitymentioning

confidence: 99%

Immuno-biochemical evaluations of phenol and thimerosal as antigen preservatives in Montenegro skin test

Mayrink¹,

Machado-Coelho²,

Guimarães³

et al. 2006

Acta Tropica

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IgA detection in human neurocysticercosis using different preparations of heterologous antigen

2010

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Neurocysticercosis (NC) is the most important neurological disease of parasitic origin in humans. IgA and IgG detection in serum from neurocysticercosis patients was tested using some antigenic preparations of total saline extract from Taenia saginata: detergent (D) and aqueous (A) phases extracted with Triton X-114 and the jacalin bound (JBF) and unbound fractions (JUF) obtained by affinity chromatography using jacalin column. Samples were obtained from 45 patients with definitive NC, who were subdivided into active-NC group and inactive-NC group; 35 patients with other parasitoses; and 30 apparently healthy individuals. Sensitivity and specificity were calculated. Specificity to detect IgA and IgG for D phase, respectively, were 89.8% and 86.9% and for IgG detection 91.3% and 76.8% when using D phase and JUF, respectively. D phase and JBF proved to be specific and efficient and could be efficiently utilized as an alternative antigen for IgA detection in NC, with comparable results with IgG.

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Assessment of immunity induced in mice by glycoproteins derived from different strains and species of Leishmania

Cited by 9 publications

References 34 publications

Characterization ofLeishmania donovaniAntigens Encapsulated in Liposomes That Induce Protective Immunity in BALB/c Mice

Characterization ofLeishmania donovaniAntigens Encapsulated in Liposomes That Induce Protective Immunity in BALB/c Mice

Immuno-biochemical evaluations of phenol and thimerosal as antigen preservatives in Montenegro skin test

IgA detection in human neurocysticercosis using different preparations of heterologous antigen

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