Parasitism of adipocytes by Trypanosoma cruzi

Andrade, Zilton A.; Silva, Honassys R. Rocha

doi:10.1590/s0074-02761995000400018

Cited by 22 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prior to 2005, there were some scattered reports of T. cruzi being found in AT. In a mouse model, T. cruzi was seen in brown adipose tissue (BAT) [9] and Andrade and Silva published electron micrographs of amastigotes of T. cruzi within adipocytes [10]. Combs et al .…”

Section: Parasites Find a Home In Adipose Tissuementioning

confidence: 99%

Adipose Tissue: A Safe Haven for Parasites?

Tanowitz

Scherer

Mota

et al. 2017

Trends in Parasitology

View full text Add to dashboard Cite

Adipose tissue (AT) is no longer regarded as an inert lipid storage, but as an important central regulator in energy homeostasis and in immunity. Three parasite species are uniquely associated with AT during part of their life cycle: Trypanosoma cruzi, the causative agent of Chagas disease, Trypanosoma brucei, the cause of African sleeping sickness and Plasmodium spp, the cause of malaria. In the AT, T. cruzi resides inside adipocytes, T. brucei is found in the interstitial spaces between adipocytes, while Plasmodium spp. infect red blood cells that may adhere to the blood vessels supplying AT. We will discuss how each parasite species adapts to this tissue environment and what the implications are for pathogenesis, clinical manifestations and therapy.

show abstract

Section: Parasites Find a Home In Adipose Tissuementioning

confidence: 99%

Adipose Tissue: A Safe Haven for Parasites?

Tanowitz

Scherer

Mota

et al. 2017

Trends in Parasitology

View full text Add to dashboard Cite

show abstract

“…T. cruzi was first described as parasitizing adipose tissue and adipocytes in the 1970s [40,41] and 1990s [42]. Combs et al in 2005 [43] published the functional consequences of parasitism of adipose tissue and adipocytes in a mouse model.…”

Section: Clinical Chagas Disease and Pathologymentioning

confidence: 99%

Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease

et al. 2012

View full text Add to dashboard Cite

Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in non-endemic areas due to immigration. The parasite may persist in any tissue, but in recent years there has been increased recognition of adipose tissue both as an early target of infection and a reservoir of chronic infection. The major complications of this disease are cardiomyopathy and megasyndromes involving the gastrointestinal tract. The pathogenesis of Chagas disease is complex and multifactorial involving many interactive pathways. The significance of innate immunity, including the contributions of cytokines, chemokines, reactive oxygen species, and oxidative stress, has been emphasized. The role of the components of the eicosanoid pathway such as thromboxane A2 and the lipoxins has been demonstrated to have profound effects as both pro-and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A2 and endothelin-1n Chagas disease. Human immunity to T. cruzi infection and its role in pathogen control and disease progression have not been fully investigated. However, recently, it was demonstrated that a reduction in the anti-inflammatory cytokine IL-10 was associated with clinically significant chronic chagasic cardiomyopathy.

show abstract

“…Although we were not the first group to observe T. cruzi in fat cells (Andrade & Silva 1995), we published the first systematic analysis of the detailed events occurring during acute and chronic stages of T. cruzi infection in fat (Combs et al 2005, Nagajyothi et al 2008). Intracellular amastigotes were monitored by electron microscopy (Fig.…”

Section: T Cruzi Infection Diabetes and Adipose Tissuementioning

confidence: 99%