Studies on the replication of Mayaro virus grown in interferon treated cells

Rebello, Maria Christina Soares; Fonseca, M. E. F.; Marinho, J. O.; Rebello, M. A.

doi:10.1590/s0074-02761994000400019

Cited by 2 publications

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“…According to Rebello, Fonseca et al (1993) the replication of the MAYV is drastically inhibited by INF activity [33]. However, our study revealed that the challenge performed in cells constitutively expressing shRNA with MAYV did not present differences in the number of plaques formed among cells and controls.…”

Section: Discussionmentioning

confidence: 63%

RNA interference inhibits yellow fever virus replication in vitro and in vivo

et al. 2009

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RNA interference (RNAi) is a process that is induced by double stranded RNA and involves the degradation of specific sequences of mRNA in the cytoplasm of the eukaryotic cells. It has been used as an antiviral tool against many viruses, including flaviviruses. The genus Flavivirus contains the most important arboviruses in the world, i.e., dengue (DENV) and yellow fever (YFV). In our study, we investigated the in vitro and in vivo effect of RNAi against YFV. Using stable cell lines that expressed RNAi against YFV, the cell lines were able to inhibit as much as 97% of the viral replication. Two constructions (one against NS1 and the other against E region of YFV genome) were able to protect the adult Balb/c mice against YFV challenge. The histopathologic analysis demonstrated an important protection of the central nervous system by RNAi after 10 days of viral challenge. Our data suggests that RNAi is a potential viable therapeutic weapon against yellow fever.

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Section: Discussionmentioning

confidence: 63%

RNA interference inhibits yellow fever virus replication in vitro and in vivo

et al. 2009

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Mayaro Virus: The State-of-the-Art for Antiviral Drug Development

Andreolla

Borges

Bordignon

et al. 2022

Viruses

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Mayaro virus is an emerging arbovirus that causes nonspecific febrile illness or arthralgia syndromes similar to the Chikungunya virus, a virus closely related from the Togaviridae family. MAYV outbreaks occur more frequently in the northern and central-western states of Brazil; however, in recent years, virus circulation has been spreading to other regions. Due to the undifferentiated initial clinical symptoms between MAYV and other endemic pathogenic arboviruses with geographic overlapping, identification of patients infected by MAYV might be underreported. Additionally, the lack of specific prophylactic approaches or antiviral drugs limits the pharmacological management of patients to treat symptoms like pain and inflammation, as is the case with most pathogenic alphaviruses. In this context, this review aims to present the state-of-the-art regarding the screening and development of compounds/molecules which may present anti-MAYV activity and infection inhibition.

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Studies on the replication of Mayaro virus grown in interferon treated cells

Cited by 2 publications

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RNA interference inhibits yellow fever virus replication in vitro and in vivo

RNA interference inhibits yellow fever virus replication in vitro and in vivo

Mayaro Virus: The State-of-the-Art for Antiviral Drug Development

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