Sialoglycoconjugates in Trypanosoma cruzi-host cell interaction: possible biological model - a review

Vermelho, Alane Beatriz; Meirelles, Maria de Nazareth Leal de

doi:10.1590/s0074-02761994000100013

Cited by 17 publications

(12 citation statements)

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“…Although parasites generally cannot transfer sialic acid to their glycoproteins from CMP-sialic acid, sialic acid is an important ligand for trypanosomes on the host cell surface [Vermelho and Meirelles, 1994]. Epimastigotes and trypomastigotes of Trypanosoma cruzi contain a surface trans-sialidase that utilizes host cell surface α2-3-linked sialic acid as a substrate to sialylate their own glycoproteins [Schenkman et al, 1993;Takahashi et al, 1995].…”

Section: Parasitic Infectionsmentioning

confidence: 99%

Glycoproteins and Their Relationship to Human Disease

Brockhausen

Schutzbach

Kuhns

1998

Cells Tissues Organs

164

105

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Glycoproteins are proteins that carry N- and O-glycosidically-linked carbohydrate chains of complex structures and functions. N-glycan chains are assembled in the endoplasmic reticulum and the Golgi by a controlled sequence of glycosyltransferase and glycosidase processing reactions involving dolichol intermediates. The assembly of O-glycans occurs in the Golgi and does not involve dolichol. For most reactions, families of glycosyltransferases exist; the expression of the individual enzymes within a family is often subject to complex regulation. The biosynthesis of N- and O-glycan is controlled at the level of gene expression, mRNA, enzyme protein activity and localization, and through substrate and cofactor concentrations at the site of synthesis. This complex regulation results in many hundreds of structures, the range of which varies in different species, cell types, tissue types, states of development and differentiation. In diseased cells, the relative proportions of these structures are often characteristically different from normal, and may be useful for the assessment of the stage of the disease and for diagnosis. Knowledge of disease-specific glycoprotein structures and their functions may be used therapeutically, in immunotherapy, in blocking cell adhesion or interfering with other binding or biological processes. Recently, some of the mechanisms underlying glycoprotein alterations in disease have been elucidated. This opens the possibility of an active interference in the disease process. The functions of glycans in diseased cells will become more clear with the tools of molecular biology and transgenic animal models.

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Section: Parasitic Infectionsmentioning

confidence: 99%

Glycoproteins and Their Relationship to Human Disease

Brockhausen

Schutzbach

Kuhns

1998

Cells Tissues Organs

164

105

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“…Culture-derived metacyclic forms had decreased their capacity to invade cells and whenever becoming intracellular were destroyed inside phagolysosomes (Contreras et al 1994). There is increasing evidence that the entry of T. cruzi invasive forms into mammalian cells involves glycoconjugates-dependent attachment followed by parasite internalization (Andrews et al 1984, Yoshida et al 1990, 1997, Schenkman et al 1993, Ramirez et al 1993, Vermelho & Meirelles 1994, Burleigh & Andrews 1995. The glycoconjugates, including glycolips and glycoproteins may therefore play a role important in the virulence of the parasites.…”

mentioning

confidence: 99%

Trypanosoma cruzi: Maintenance in Culture Modify Gene and Antigenic Expression of Metacyclic Trypomastigotes

Contreras

Lima²,

Zorrilla³

1998

Mem. Inst. Oswaldo Cruz

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“…It has been described that during the formation of the PV some host cell plasma membrane components will be part of the membrane of the PV, but other components will not be found in the membrane which lines the PV. The involvement of glycoconjugates in this invasion have shown that a number of carbohydrates -such as galactose, N-acetyl galactosamine, Nacetyl glucosamine, mannose and sialic acid -components of glycoproteins and glycolipids present on the surface of both parasite and/or host cell may participate in the interaction process (Andrews & Coli 1981, Crane & Dvorak 1982, Vilalta & Kierzenbaum 1983, Zingales & Coli 1985, Meirelles et al 1986, Piras et al 1987, Ouassi 1988, Vermelho et al 1992, Barbosa & Meirelles 1992, Schenkman & Eichinger 1993, Vermelho & Meirelles 1994, Soeiro et al 1995. Mannosyl residues and their counter-receptors play an important role during the interaction of T. cruzi and host cells.…”

Section: Cardiomyocytes (Cm) Are the Main Targets Formentioning

confidence: 99%