Declaration of Brazil to the Ministerial Conference on Malaria

A Diterpene fromMikania obtusataActive onTrypanosoma cruzi

“…With the control of the insect vector, transfusion with infected blood has become the most importailt mode of transmission of the disease. In the 1970's blood transfusion was responsible for 20,000 new cases per year in Brazil alone (2). Besides the serological screening of the donors, the clearing of banked blood with gentian violet is an important measure to prevent this mode of transmission.…”

“…Besides the serological screening of the donors, the clearing of banked blood with gentian violet is an important measure to prevent this mode of transmission. However, due to some undesired effect over elements of blood (3), controversies about its mutagenic effect (4) and the bluish color it impairs to treated patients, its use is in decline (2).…”

Trypanosomicidal Kaurane Diterpenes fromWedelia paludosa

“…Besides the screening of the donors, the chemosterilization of the blood for transfusion with gentian violet is the only prophylactic measure available. However, due to some undesired effects on elements of blood, its use is decreasing significantly (2).…”