Successful vaccination against Boophilus microplus and Babesia bovis using recombinat antigens

Willadsen, Peter; Kemp, D. H.; Cobon, Gary S.; Wright, I. G.

doi:10.1590/s0074-02761992000700049

Cited by 16 publications

(4 citation statements)

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“…Additionally, vaccines can complement other ixodid control tactics with the aim of mitigating the development of resistance to acaricides [ 250 ] Vaccines can be designed to deploy multiple antigens, enabling protection for a wide range of host species against multiple ixodid species [ 251 ]. As an example of current efforts to develop anti-ixodid vaccines, candidate vaccines are being investigated with the goal of providing prophylactic protection of cattle from R. microplus [ 252 ], while recent efforts using recombinant antitick vaccines afforded nearly 82% efficacy against tick infestation [ 253 ]. Additional vaccine development opportunities exist, with a current focus on improving identification and characterization of ixodid antigens that can then be generated in the laboratory [ 254 ].…”

Section: Vaccinesmentioning

confidence: 99%

Integrative Alternative Tactics for Ixodid Control

Showler

Saelao

2022

Insects

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Ixodids (hard ticks), ectoparasitic arthropods that vector the causal agents of many serious diseases of humans, domestic animals, and wildlife, have become increasingly difficult to control because of the development of resistance against commonly applied synthetic chemical-based acaricides. Resistance has prompted searches for alternative, nonconventional control tactics that can be used as part of integrated ixodid management strategies and for mitigating resistance to conventional acaricides. The quest for alternative control tactics has involved research on various techniques, each influenced by many factors, that have achieved different degrees of success. Alternative approaches include cultural practices, ingested and injected medications, biological control, animal- and plant-based substances, growth regulators, and inert desiccant dusts. Research on biological control of ixodids has mainly focused on predators, parasitoid wasps, infective nematodes, and pathogenic bacteria and fungi. Studies on animal-based substances have been relatively limited, but research on botanicals has been extensive, including whole plant, extract, and essential oil effects on ixodid mortality, behavior, and reproduction. The inert dusts kaolin, silica gel, perlite, and diatomaceous earth are lethal to ixodids, and they are impervious to environmental degradation, unlike chemical-based toxins, remaining effective until physically removed.

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Section: Vaccinesmentioning

confidence: 99%

Integrative Alternative Tactics for Ixodid Control

Showler

Saelao

2022

Insects

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“…Several publications have outlined the stages in the development of Bm86-based vaccines commercialized before (Canales et al 1997;De la Fuente et al 1999;De la Fuente et al 1998;Jittapalapong et al 2006;Rodriguez-Mallon 2016;Willadsen 2008b;Willadsen et al 1992Willadsen et al , 1995. In the case of TickGard®, it took 14 years and testing in thousands of cattle to complete demonstration of feasibility, documentation of efficacy in field trials, completion of product registration, and post-marketing product surveillance to complete the commercialization process (Willadsen 2008b;Willadsen et al 1995).…”

Section: Past Experiences Developing Bm86-based Vaccinesmentioning

confidence: 99%

1. Livestock pests and vector-borne diseases – a much neglected subject

Takken¹,

Bouyer²,

Smallegange³

et al. 2018

Pests and Vector-Borne Diseases in the Livestock Industry

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Worldwide the livestock industry, from small farmers to large industrialized farms, is affected by arthropods and arthropod-borne diseases at various scales, which cause huge losses and are a constraint to socio-economic development. Farmers make considerable efforts to prevent and control pest and disease incidence, often requiring the use of vaccines, if available, drugs and pesticides. Examples of current problems are presented, to set the stage for the detailed and state-of-the-art presentations of specific cases of livestock pests and their associated diseases and modern methods of prevention and control.

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“…More investment in alternatives for tick control and acaricide resistance management are necessary. Some work has been carried out on biological control, mainly with fungi (Onofre et al 2001), and impressive results can be obtained with tick vaccines (Willadsen et al 1992). The use of resistant hosts has shown to be effective (Frisch, 1999), but more research is needed.…”

Section: A C a R I C I D E R E G I S T R A T I O N U S E M I S-mentioning

confidence: 99%

Tick control: an industry point of view

Gogolewski²,

et al. 2004

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The development of new acaricides is a long and very expensive process. Worryingly, there is increasing resistance to available acaricides worldwide leading to the real possibility that our dwindling supply of effective acaricides will be exhausted unless action is taken to increase the number of new acaricidal products and reduce the rate of resistance development. In 1995, eight major animal health pharmaceutical companies formed the Veterinary Parasite Resistance Group (VPRG) to act as an expert consultative group to guide the FAO in resistance management and collaborate in the prudent use of acaricides. In this paper, members of the VPRG discuss the problems and processes in acaricide development, resistance in the field to commonly used acaricides and the different considerations when targeting the cattle and pet market, and give their view of the future for tick control from the perspective of the animal health industry.

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Successful vaccination against Boophilus microplus and Babesia bovis using recombinat antigens

Cited by 16 publications

References 0 publications

Integrative Alternative Tactics for Ixodid Control

Integrative Alternative Tactics for Ixodid Control

1. Livestock pests and vector-borne diseases – a much neglected subject

Tick control: an industry point of view

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