Chondroitin 4- and 6-sulfate in growth and articular cartilage of young and adult humans

Chondroitin Sulfate Promotes Activation of Cathepsin K

“…It also possesses important biological properties for tissue integration, such as anti-inflammatory activity and nutrient absorption (25,26). The sulfated linear polysaccharide chondroitin 4-sulfate (C4-S) is present in bone and is abundantly detected in articular cartilage (27,28). C4-S has recently been demonstrated to directly interact with mature CatK and to promote its triple-helical collagenase activity (29,30).…”