Sesquiterpene lactones from Vernonia

Lopes, João Luís Callegari

doi:10.1590/s0074-02761991000600050

Cited by 12 publications

(9 citation statements)

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“…The Brazilian folk medicine has shown great evidence that the crude extract prepared from leaves of V. condensata is able to prevent stomach and liver disturbances (2). As previously reported, sesquiterpene lactone compounds isolated from some species of Vernonia exhibited anti-fungal and anti-tumoral properties (1).…”

Section: Introductionsupporting

confidence: 56%

“…Moreover the lactone glaucolide B isolated from V. eremophila Mart. ex DC presented anti-nociceptive activity without modifying the edema caused by carrageenin, suggesting an analgesic mechanism hidependent of cyclooxygenase metabolites (1).…”

Section: Introductionmentioning

confidence: 90%

“…Vernonia condensata Baker is a bush widely distributed in several Brazihan States, including Rio de Janeiro, São Paulo, Minas Gerais, and Bahia. The plant belongs to the genus Vernonia (Vernonieae, Compositae) which is largely represented in Brazil with about 200 catalogued species, though only 15% of them have been already investigated (1). The Brazilian folk medicine has shown great evidence that the crude extract prepared from leaves of V. condensata is able to prevent stomach and liver disturbances (2).…”

Section: Introductionmentioning

confidence: 99%

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Analgesic and Anti-Ulcerogenic Effects of a Polar Extract from Leaves ofVernonia condensata

Frutuoso

Gurjão²,

Cordeiro³

et al. 1994

Planta Med

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An aqueous crude extract and a polar fraction derived from this extract were prepared from leaves of Vernonia condensata Baker and assessed in standard rodent models of algesia and ulcerogenesis. Oral pretreatment with the lyophilized crude extract (200 mg/kg) significantly reduced mouse writhing counts caused by the i.p. injection of increasing concentrations (0.6-1.2%) of acetic acid (0.1 ml/10 g). In doses ranging from 50 to 400 mg/kg, the crude extract inhibited dose-dependently mouse writhing induced by acetic acid (0.6%) (ED50 = 241 mg/kg) and also markedly increased the sleeping time induced by thiopental. The polar fraction, prepared by washing out the crude extract with chloroform, did not alter sleeping time but kept the analgesic activity (ED50 = 154 mg/kg), indicating that these effects are indeed dissociated. In contrast, the tail flick response in the immersion test was not modified by the crude extract or the polar fraction. The relative potency with which polar fraction and non-steroidal anti-inflammatory drugs inhibited mouse writhing caused by acetic acid in mice was indomethacin >> dypirone > polar fraction > aspirin. Furthermore, the combined polar fraction/aspirin or polar fraction/indomethacin treatments presented a marked synergistic effect, in contrast to what was observed when submaximal doses of indomethacin and aspirin were coadministered, suggesting that polar fraction and aspirin like drugs may have complementary analgesic actions. Finally, despite being able to potentiate the analgesic effect of indomethacin in mouse writhing caused by acetic acid, the pretreatment with the polar fraction (200 mg/kg, oral) significantly prevented indomethacin-induced ulcers in rats.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Analgesic and Anti-Ulcerogenic Effects of a Polar Extract from Leaves ofVernonia condensata

Frutuoso

Gurjão²,

Cordeiro³

et al. 1994

Planta Med

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“…The crude extract can be dangerous in the initial wound healing stage in non-infected lesions, but our results showed that in infected ulcers this is not the case, indicating a possible antibacterial activity of V. scorpioides compounds. In the tribe Vernonieae (family: Asteraceae) sesquiterpene lactones (Lopes, 1991) are found, for which the different biological effects are described. The data suggest that these compounds have anti-inflammatory and anti-ulcer (Feltenstein et al, 2004), anti-malarial (Chung & Moon, 2009), and antibacterial (Ntutelaa et al, 2009, Saroglou et al, 2010 properties.…”

Section: Discussionmentioning

confidence: 99%

“…There are about 200 species of Vernonia in Brazil, some of which are traditionally used in folk medicine (Lopes, 1991). Different biological effects of the sesquiterpene lactones species from Vernonia are described.…”

Section: Introductionmentioning

confidence: 99%

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

Kreuger¹,

Farias²,

Moreira³

et al. 2012

Rev. bras. farmacogn.

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Abstract:We investigated the healing process on excisional wounds infected with Staphylococcus aureus in rats, treated with 50 μL of ethyl acetate III from Vernonia scorpioides (Lam.) Pers., Asteraceae, rifamycin diethylamide B 25 mg, or saline. The lesions were measured daily and after seven days were surgically removed and histologically processed. The results indicate a favorable action of the EAIII, demonstrated by the increased wound contraction, smaller area of necrotic tissue, good development of granulation tissue, extensive extracellular matrix deposition and epithelial regeneration. This sub-fraction was phytochemically investigated in parallel studies, revealing the presence of sesquiterpene lactones (glaucolides and hirsutinolides) such as diacethylpiptocarphol and related hirsutinolides, flavonoids and cinnamic acid derivatives and also a new polyacetylene, which have been previously published. Results support the effectiveness of V. scorpioides antimicrobial activity in infected wound healing in rats.

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LC-UV-HRMS dereplication of secondary metabolites from Brazilian Vernonieae (Asteraceae) species supported through in-house database

Gallon

Jaiyesimi

Gobbo‐Neto

2018

Biochemical Systematics and Ecology

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Sesquiterpene lactones from Vernonia

Abstract: Some informations about the sesquiterpene lactones isolated from Brazilian species of Vernonia are described, as well the results of tests developed with such compounds with respect to their anti-feedant, molluscicide, antimicrobial and analgesic properties.

Cited by 12 publications

References 0 publications

Analgesic and Anti-Ulcerogenic Effects of a Polar Extract from Leaves ofVernonia condensata

Analgesic and Anti-Ulcerogenic Effects of a Polar Extract from Leaves ofVernonia condensata

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

LC-UV-HRMS dereplication of secondary metabolites from Brazilian Vernonieae (Asteraceae) species supported through in-house database

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