Immunomodulating Chinese herbal medicines

Li, Xiaoyü

doi:10.1590/s0074-02761991000600036

Cited by 37 publications

(25 citation statements)

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“…Sun et al (2003) obtained similar findings with PNS. Polysaccharides from P. notoginseng exhibited an immunoenhancing action (Li 1991). Sanchinan-A is an arabinogalactan from P. notoginseng that activated the reticuloendothelial system (Ohtani et al 1987).…”

Section: Immunological Adjuvant Activity and Immunostimulatory Actionmentioning

confidence: 99%

Pharmacological activity of sanchi ginseng (Panax notoginseng)

2006

Journal of Pharmacy and Pharmacology

353

215

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The pharmacological activity and constituents of the sanchi ginseng Panax notoginseng have been reviewed. The bulk of pharmacological findings have been based on the saponins or steryl glycosides, although polysaccharides with immunopotentiating activity, proteins with antifungal, ribonuclease and xylanase activity, and a triacylglycerol (trilinolein) with antioxidant activity have been reported. Protective actions against cerebral ischaemia, beneficial effects on the cardiovascular system, and haemostatic, antioxidant, hypolipidaemic, hepatoprotective, renoprotective and estrogen-like activities have been described. Various methods for authentication of P. notoginseng are available.

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Section: Immunological Adjuvant Activity and Immunostimulatory Actionmentioning

confidence: 99%

Pharmacological activity of sanchi ginseng (Panax notoginseng)

2006

Journal of Pharmacy and Pharmacology

353

215

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“…However, this medication has significant urinary and hematological adverse effects in substantial numbers of treated patients (3,4). Therefore, it is necessary to explore a new traditional Chinese medicine which could be both efficacious and less side-effect.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus

Ouyang

Zhang

et al. 2009

Cell Mol Immunol

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Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease. In this study, we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model. MRL/lpr mice were divided into control, cyclophosphamide (CTX) and artesunate treatment groups. Blood was collected to measure serum levels of creatinine, antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) antibody. Twenty-four-hour urine was collected to measure levels of proteinuria. The concentration of monocyte chemotactic protein-1 (MCP-1) in serum and urine was measured. The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay, respectively. The expression of B cell activating factor (BAFF) in spleen was determined by real time-PCR and immunoblotting. We found that artesunate significantly increased the survival rate, body weight and blood leukocyte counts, and reduced the serum levels of ANA and anti-dsDNA antibody titer, 24 h urinary protein, and serum creatinine. Our results indicated that artesunate could decrease MCP-1, major pro-inflammation cytokine, in serum, urine and kidney. We also found that the level of BAFF, the major B cell activation factor, was decreased in artesunate treated MRL/lpr mice. Its efficacy was comparable with that of CTX in this study. Taken

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“…The stem bark of Periploca sepium Bge, a traditional Chinese herb medicine, has been widely used in the treatment of autoimmune diseases, especially for rheumatoid arthritis (Li, 1991). In this study, large numbers of components from P. sepium Bge have been tested in vitro using bioactivity-guided isolation screening assay to identify the most potent immunosuppressive compound that may be responsible for the anti-rheumatoid arthritis effects in P. sepium Bge.…”

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confidence: 99%

Periplocoside E, an Effective Compound fromPeriploca sepiumBge, Inhibited T Cell Activation in Vitro and in Vivo

Zhu¹,

Zhao²,

Yang³

et al. 2005

J Pharmacol Exp Ther

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Periploca sepium Bge, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. Followed the bioactivity-guided isolation, the most potent immunosuppressive compound, periplocoside E (PSE), a pregnane glycoside, had been identified from P. sepium Bge. We investigated the immunosuppressive effects of PSE in vitro and in vivo. The results showed that PSE in a dose-dependent manner significantly inhibited the proliferation of splenocytes induced by concanavalin A and mixed lymphocyte culture reaction at no cytotoxic concentrations (Ͻ5 M). Administration of PSE suppressed a delayed-type hypersensitivity reaction, and ovalbumin (OVA) induced antigen-specific immune responses in mice. In vivo treatment with PSE dose dependently suppressed OVAinduced proliferation and cytokine [interleukin (IL)-2 and interferon (IFN)-␥] production from splenocytes in vitro. Purified T cells from OVA-immunized mice with PSE treatment showed its low ability for activation by OVA plus normal antigen presenting cell stimulation again in vitro. Further studies showed PSE dose dependently inhibited anti-CD3-induced primary T cell proliferation, activation for IL-2R␣ (CD25) expression, and cytokine (IFN-␥ and IL-2) production also at the transcriptional level. PSE was highly specific and significantly inhibited the activation of extracellular signal-regulated kinase and Jun N-terminal kinase, whereas activation of p38 was not affected in T cells stimulated with anti-CD3. These results demonstrated that PSE is an immunosuppressive compound in P. sepium Bge, which directly inhibits T cell activation in vitro and in vivo. This study provided evidence to understand the therapeutic effects of P. sepium Bge and indicated that this herb is appropriate for treatment of T cell-mediated disorders, such as autoimmune diseases.

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Immunomodulating Chinese herbal medicines

Cited by 37 publications

References 0 publications

Pharmacological activity of sanchi ginseng (Panax notoginseng)

Pharmacological activity of sanchi ginseng (Panax notoginseng)

A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus

Periplocoside E, an Effective Compound fromPeriploca sepiumBge, Inhibited T Cell Activation in Vitro and in Vivo

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