Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart

Abstract

Baccharis triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/kg, p.o.) did not alter spontaneous motor activity, sleeping time induced by barbiturates or the tail-flick response in mice. The extract decreased by 40% the number of writhings induced by 0.8% acetic acid, i.p., but did not influence paw edema induced by carrageenan or dextran in rats. WE (2 g/kg, p.o.) decreased the intestinal transit of charcoal in mice by 20%. Gastric secretion in pylorus ligated rats was reduced after treatment with WE (1 and 2 g/kg, i.p. or intraduodenal) and the gastric pH was raised. The extract (1 g/kg, p.o.) prevented gastric ulcers induced in rats by immobilization at 4 degrees C, but not those induced by indomethacin (10 mg/kg, s.c.). The results indicate that WE may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hiperactivity. Neither analgesic nor anti-inflammatory activities were detectable.

Atividade antiulcerogênica do extrato aquoso de Salvia officinalis L. (Lamiaceae)

“…Os conteúdos gástricos foram desprezados e os estômagos abertos ao longo da curvatura maior. As mucosas gástricas foram lavadas com água destilada e mantidas em placas de Petry sendo avaliadas de acordo com uma tabela de escores (Gamberini et al, 1991) Análise estatística Na análise fitoquímica os resultados foram representados por meio da média ± desvio padrão (DP) e coeficiente de variação (%). Os resultados da parte experimental in vivo foram expressos como média ± DP e submetidos à análise de variância (ANOVA) one way e teste de Tukey para comparação de médias.…”

The features of reserpine-induced gastric mucosal lesions

“…24 h later, each stomach was dissected along the greater curvature and rinsed with tap water to remove the gastric contents. The ulcerative lesion index of each rat was calculated by adding the values in Table 1, according to methodology described by Gamberini et al [15] .…”

Antiulcerogenic effects of Gymnosporia rothiana

“…Free acidity, total acidity, volume and pH of gastric content were calculated as per standard methods. Ulcer lesion index calculated by severity of gastric mucosal lesion (Gamberini et al, 1991) graded as follows: 1) Loss of normal morphology, discoloration of mucosa, mucosal damage, hemorrhagic streaks (1 point each) 2) petechial point (< 10, 2 points, 10, 3 points) and 3) No. / Size of the ulcers (number of ulcer until 1 mm x 2 points, larger than 1 mm × 3 points) 4) perforated ulcer (number of ulcer x 4 points).…”