T cell responses in mice infected and immunized with Trypanosoma cruzi

Organ‐Specific Regulation of Interferon‐γ, Interleukin‐2 and Interleukin‐2 Receptor during Murine Infection with Trypanosoma cruzi

“…Concomitantly, while lymph node cells from mice at 21 dpi were able to proliferate and express IL-2R in response to Con A, spleen cells were not. Dissimilar proliferative responses of lymph node and spleen cells from mice during the acute infection with T. cruzi have been reported [39], DitTerent quantities of parasites or parasite-derived soluble suppressor factors, and qualitative or quantitative diflerences in the infection-induced suppressor cells,, could account tor our observation. A subcutaneous infection with a high (3 x 10-) but not a lower dose (5 x 10') of 7".…”

“…A subcutaneous infection with a high (3 x 10-) but not a lower dose (5 x 10') of 7". iruzi{\ strain) suppressed the mitogenic response of draining (but not distant) lymph node cells [39]. F'ollowing intraperitoncul infection, this suppression was not observed.…”

“…Spleen cell proliferation was suppressed during the acute phase ofinfection. independently ofthe size oi'the inocula and the inoculation route [39]. This suggests that a critical number of parasites or parasite-derived factors must be present in the lymph node to achieve the suppression of mitogenic responses.…”