The split within the CD4 (helper) T-cell subset, and its implications for immunopathology

Marvel, Jacqueline; Mitchison, N. A.; Oliveira, D. B. G.; O’Malley, Catherine

doi:10.1590/s0074-02761987000500009

Cited by 4 publications

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“…In the older hapten-carrier experiments, of which this study is no more than an extension, unlinked antigen (i.e. hapten on a second carrier) proved able to induce a response at a protein dose of 100-1000 pYmouse [8]. This is about 100 times more than the maximum dose of H-2Db molecules used here, and that is sufficient to explain why the unlinked cellular antigen proved so ineffective in the present study.…”

Section: Discussionmentioning

confidence: 41%

An exact comparison between the efficiency of two‐ and three‐cell‐type clusters in mediating helper activity

Mitchison

1990

Eur J Immunol

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Adoptive transfer of anti-H-2Db-primed B cells combined with anti-minor histocompatibility antigen-primed T cells enables the effect of linked and unlinked alloantigen to be compared. Over an extensive dose range the unlinked antigen proved ineffective. In a previously described, exactly comparable system for assessing the same effect on cytotoxic T cell precursors, low doses of linked antigen had proved approximately equally effective, but high doses of unlinked antigen had proved effective. This contrast supports the hypothesis that whereas T-B collaboration is mediated by two-cell-type clusters, collaboration between T cells requires formation of three-cell-type clusters.

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Section: Discussionmentioning

confidence: 41%

An exact comparison between the efficiency of two‐ and three‐cell‐type clusters in mediating helper activity

Mitchison

1990

Eur J Immunol

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“…Opinions among immunologists vary from those who regard this cell as playing a fundamental role in regulation of the immune response, to those who regard it as no more than an illusion. My own opinion, expressed in several recent and forthcoming reviews [4][5][6][7], lies somewhere between these two poles. I think it likely that a suppressor mechanism does operate, and that it has evolved primarily as a measure to counteract that threat of hypersensitivity.…”

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confidence: 99%

Logical Structure of the Immunoregulatory Compartment

Mitchison

1989

Haematology and Blood Transfusion / Hämatologie Und Bluttransfusion

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CD45R gives immunofluorescence and transduces signals on mouse T cells

Marvel

Mayer

1988

Eur J Immunol

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The expression of CD45R on mouse T cells has been studied. This antigen is expressed on the two higher molecular weight bands of CD45 (or T200) and in mouse it is currently used as a marker of B cells (B220). Here we confirm that CD45R is expressed on some mouse T cell clones. We show that a small but measurable proportion of mouse spleen and peripheral blood lymphocyte T cells gives positive immunofluorescence with B220. Also CD45R-specific antibodies increase the proliferation response to phytohemagglutinin up to 3-fold, thus confirming that CD45R molecules transduce a signal into mouse T cells.

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The split within the CD4 (helper) T-cell subset, and its implications for immunopathology

Cited by 4 publications

References 0 publications

An exact comparison between the efficiency of two‐ and three‐cell‐type clusters in mediating helper activity

An exact comparison between the efficiency of two‐ and three‐cell‐type clusters in mediating helper activity

Logical Structure of the Immunoregulatory Compartment

CD45R gives immunofluorescence and transduces signals on mouse T cells

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