Human cerebral malaria: a pathological study

Aikawa, Masamichi; Oo, Maung Maung; Igarashi, Ikuo

doi:10.1590/s0074-02761986000600031

Cited by 2 publications

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“…These findings evidence hypoxia and ischaemia as important components in the pathogenesis of CM. Mechanical obstruction of blood flow by adherent pRBCs has long been considered as the central mechanism leading to CM (Aikawa et al 1987, Pongponratn et al 2003, White et al 2010, 2013). However, it is becoming increasingly clear that blood vessel function in CM is compromised well beyond occlusion.…”

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confidence: 99%

Vascular dysfunction as a target for adjuvant therapy in cerebral malaria

Carvalho

Moreira

Daniel-Ribeiro

et al. 2014

Mem. Inst. Oswaldo Cruz

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Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.

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confidence: 99%