Protective antibodies to plasmodium falciparum and immunity to malaria in an endemic area of Brazil

Tosta, Carlos Eduardo; Moura, Rômulo Cesar Sabóia

doi:10.1590/s0074-02761986000600029

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a limited number of studies on immune responses to CS protein in individuals who live in endemic areas of Brazil. In general, they are restricted to studies on the prevalence of antibodies against the repeats of the CS protein of P. falciparum (Tosta & Moura 1986, Oliveira-Ferreira et al 1992) and, more recently, of P. vivax (Kremsner et al 1992). Studies comparing the response of the CS protein from P. falciparum to that of P. vivax have not been carried out in parallel, even though in a large part of the Brazilian Amazon these parasites occur simultaneously (Marques & Gutiérrez 1994).…”

Section: Introductionmentioning

confidence: 99%

Cross‐reactive cellular immune response to circumsporozoite proteins of Plasmodium vivax and P. falciparum in malaria‐exposed individuals

Carvalho

Fontes

Fernandes

et al. 1997

Parasite Immunology

View full text Add to dashboard Cite

Acquired immunity against the recombinant circumsporozoite protein of P. falciparum (rPfCS) or P. vivax (rPvCS) was studied in two malarious areas of the Brazilian Amazon. Cellular responsiveness, evaluated by proliferative assays, was detected in about 45% of individuals who had recovered from recent acute malaria infections. Peripheral blood mononuclear cells of individuals whose last malaria infection was by P. vivax responded more to the rCS proteins than those who had P. falciparum. Since in P. vivax infections hypnozoites in the liver retain CS antigen, this stage may have contributed to the increased cellular response. The unexpected result was that in primoinfections by P. falciparum or P. vivax the proliferative response did not correspond to the rPfCS and rPvCS, respectively. Furthermore, among the malaria-exposed individuals, there was a positive correlation between the intensity of the responses to the two rCS proteins. Our results suggest that cross-reactive epitopes exist in the CS protein of P. falciparum and P. vivax. In the areas studied, the frequency of antibodies against rPvCS and/or rPfCS ranged from 43% to 11%. Species-specific antibodies against the CS protein were detected in the primoinfected individuals. Some individuals living in the endemic area but with no clinical history of malaria were positive by serology (8%) or by in vitro proliferation (21%). However, antibodies and cellular responses against rCS were detected only in malaria-exposed individuals, since those living outside the endemic area were all negative.

show abstract

Section: Introductionmentioning

confidence: 99%