Polyclonal B-Lymphocyte activation and sensitization of erythrocytes by IgG in human malaria: relevance to the development of anaemia in a Holoendemic area in northwestern Brazil (Ariquemes - Rondônia)

Daniel-Ribeiro, Cláudio Tadeu; Banic, Dalma Maria; Ahmed, Ishraf Issa; Galvão–Castro, Bernardo

doi:10.1590/s0074-02761986000600028

Cited by 7 publications

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“…Furthermore, anemia can persist for weeks after effective antimalarial treatment (4,6,22,62,70). Although the pathological basis for the development of malarial anemia is not yet well understood, the participation of cytokines (5,12,21) and of autoantibodies (14,15,59,62,69) has been considered. Some works have suggested that severe anemia is associated with predominant T-helper 1 (Th1) responses, characterized by high levels of tumor necrosis factor alpha (TNF-␣) in relation to interleukin-10 (IL-10) levels, and conversely, protection from this complication was associated with an inverse relationship, i.e., with a balance toward a high IL-10/TNF-␣ ratio (37,55).…”

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confidence: 99%

Similar Cytokine Responses and Degrees of Anemia in Patients withPlasmodium falciparumandPlasmodium vivaxInfections in the Brazilian Amazon Region

Fernandes

Carvalho

Zaniní

et al. 2008

Clin Vaccine Immunol

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The mechanisms of malarial anemia induction are poorly understood, but cytokines and autoantibodies are considered to play important roles. This work aimed at evaluating the degree of anemia and the plasmatic profile of the cytokines tumor necrosis factor alpha (TNF-␣), gamma interferon (IFN-␥), interleukin-12 (IL-12), migration inhibitory factor (MIF), and IL-10 and the monocyte chemotactic protein-1 (MCP-1) chemokine, as well as evaluating the presence of antibodies directed to components of the normal erythrocyte membrane and to cardiolipin in individuals with malaria from the Brazilian Amazon. No difference was observed in the frequency of anemia between patients infected by Plasmodium vivax and those infected by Plasmodium falciparum, and there was no relationship between the levels of parasitemia and the manifestations of anemia in P. vivax and P. falciparum patients. Significant increases in the concentrations of TNF-␣, IFN-␥, MIF, and MCP-1 were observed in patients with P. falciparum and P. vivax malaria, whereas the concentrations of IL-10 was increased only in patients with P. vivax infection. Higher concentrations of IL-12 and IL-10 were observed in the P. falciparum anemic patients, while for TNF-␣ this profile was observed in the nonanemic ones. P. vivax-infected and P. falciparum-infected patients with positive immunoglobulin M (IgM) or IgM and IgG responses, respectively, against blood-stage forms of the parasites had significantly lower hemoglobin levels than did those with negative responses. There was no correlation between the presence of anti-erythrocyte and anti-cardiolipin antibodies and the presence or intensity of the anemia. Our data suggest that in areas of low endemicity and unstable transmission of malaria, P. vivax and P. falciparum infections present similar characteristics in terms of the induction of anemia and cytokine responses.Severe malarial anemia and cerebral malaria are the main complications of Plasmodium falciparum infection. They are responsible for most of the estimated one to three million malaria-related deaths every year in the world, mainly among children below 5 years of age in sub-Saharan Africa (49). Severe malarial anemia is reported to be the earliest complication, usually affecting children below 2 years of age (57). Although severe anemia is a major concern in malaria pathology due to its high mortality rates, milder forms of anemia also are important, since this manifestation is responsible for considerable morbidity and is one of the major factors for the high disability-adjusted life years attributed to malaria (50,51,66). Iron deficiency, intestinal helminths, and human immunodeficiency virus infection make significant contributions to the pathogenesis of anemia in many African countries, but now there is substantial evidence suggesting that malaria is indeed a major underlying factor (28, 48).Although it has been estimated, the real impact of malarial anemia on the affected populations is unknown. The few available data mostly are restricted to studies ...

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Similar Cytokine Responses and Degrees of Anemia in Patients withPlasmodium falciparumandPlasmodium vivaxInfections in the Brazilian Amazon Region

Fernandes

Carvalho

Zaniní

et al. 2008

Clin Vaccine Immunol

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“…Although it is known that sensitization of nRBCs by antibodies and complement system contributes to malarial anemia pathogenesis ((Daniel-Ribeiro et al, 1986); (Daniel-Ribeiro and Zanini, 2000; Waitumbi et al, 2000), there is evidence indicating that the elimination of nRBCs could also occur in an opsonin-independent manner. For instance, a lack of correlation between RBC sensitization and anemia degree has been reported in some studies with malarial patients (Abdalla, 1986; Merry et al, 1986) and a shortened lifespan of nRBCs was observed during P. yoelii induced-anemia in a B cell-deficient environment provided by severe combined immunodeficient mice (Salmon et al, 1997).…”

Section: Removing Nrbcs In Malaria By Apoptosismentioning

confidence: 99%

Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia

Totino

Daniel-Ribeiro

Ferreira-da-Cruz

2016

Front. Cell. Infect. Microbiol.

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In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources including drug therapy and infectious diseases. In malaria, severe anemia is a common complication leading to death of children and pregnant women living in malaria-endemic regions of Africa. The pathogenesis of malarial anemia is multifactorial and involves both ineffective production of RBCs by the bone marrow and premature elimination of non-parasitized RBCs, phenomena potentially associated with apoptosis. In the present overview, we discuss evidences associating erythrocytic apoptosis with the pathogenesis of severe malarial anemia, as well as with regulation of parasite clearance in malaria. Efforts to understand the role of erythrocytic apoptosis in malarial anemia can help to identify potential targets for therapeutic intervention based on apoptotic pathways and consequently, mitigate the harmful impact of malaria in global public health.

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Can malaria-associated polyclonal B-lymphocyte activation interfere with the development of anti-sporozoite specific immunity?

Daniel-Ribeiro

Oliveira-Ferreira

Banic

et al. 1989

Transactions of the Royal Society of Tropical Medicine and Hygi

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To study the relevance of polyclonal B cell activation (PBA) associated with malaria in the development of specific anti-sporozoite immunity, we used a reverse haemolytic plaque assay and an immunoradiometric assay employing the synthetic peptide (NANP)3, the main epitope of the circumsporozoite (CS) protein of Plasmodium falciparum, to assess respectively the degree of activation of IgG and IgM secreting cells and the level of anti-sporozoite antibodies in 95 subjects with malaria and 21 non-infected individuals. A positive correlation was observed between the anti-(NANP)3 antibody levels and the number of past attacks of malaria but not between the former and the age of individuals or the number of months of residence in the endemic region. Individuals with high numbers of IgG or IgM secreting cells (SC) had lower levels of anti-(NANP)3 antibodies; those with levels of antibodies above the mean for malaria-infected individuals had lower numbers of IgGSC and higher haematocrit and haemoglobin values. These data show the existence of a negative relationship between malaria-induced PBA and anti-sporozoite immunity, and it is suggested that either PBA blocks the development of anti-sporozoite immunity or, alternatively, the latter protects individuals against malaria and malaria-associated PBA.

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Polyclonal B-Lymphocyte activation and sensitization of erythrocytes by IgG in human malaria: relevance to the development of anaemia in a Holoendemic area in northwestern Brazil (Ariquemes - Rondônia)

Cited by 7 publications

References 0 publications

Similar Cytokine Responses and Degrees of Anemia in Patients withPlasmodium falciparumandPlasmodium vivaxInfections in the Brazilian Amazon Region

Similar Cytokine Responses and Degrees of Anemia in Patients withPlasmodium falciparumandPlasmodium vivaxInfections in the Brazilian Amazon Region

Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia

Can malaria-associated polyclonal B-lymphocyte activation interfere with the development of anti-sporozoite specific immunity?

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