A follow-up evaluation of Chagas' disease in two endemic areas Brazil

Coura, José Rodrigues; Pereira, João Baptista Borges

doi:10.1590/s0074-02761984000500020

Cited by 14 publications

(10 citation statements)

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“…Coura and Pereira (1984) found similar figures in a shorter period of follow-up in two endemic areas of Minas Gerais.…”

supporting

confidence: 71%

“…The definitions described above were supported by previous knowledge from classical cohort studies on disease evolution (Macêdo 1973, Prata 1975, Castro 1978, Dias 1982, Pereira 1983, Coura & Pereira 1984) and the standardized criteria for classification of clinical forms of Chagas disease defined in 1974 by a research council published by CNPq. These criteria included clinical evaluation, conventional electrocardiography with a 30 cm DII derivation, chest X rays and barium contrast studies of oesophagus and colon.…”

mentioning

confidence: 80%

“…Cohort studies developed in the endemic areas of São Felipe (Macêdo 1973), Mambaí (Castro 1978), Bambuí (Dias 1982) and Virgem da Lapa (Coura & Pereira 1984) showed that infected individuals younger than 10 had the indeterminate form in 63%, 71%, 80% and 100% respectively. Individuals between 20 and 29 years had a decrease of the indeterminate form prevalence to 44%, 58%, 39% e 42% respectively.…”

mentioning

confidence: 99%

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Indeterminate form of Chagas disease

Macêdo

1999

Mem. Inst. Oswaldo Cruz

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“…Coura and Pereira (1984) found similar figures in a shorter period of follow-up in two endemic areas of Minas Gerais.…”

supporting

confidence: 71%

mentioning

confidence: 80%

mentioning

confidence: 99%

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Indeterminate form of Chagas disease

Macêdo

1999

Mem. Inst. Oswaldo Cruz

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“…The prognosis for the digestive and indeterminate forms is generally good, except in cases of the digestive form with complications (esophageal cancer, obstruction with twisting, and colon necrosis). None of the cases of the digestive or indeterminate form that we observed over six and ten-year periods progressed to death (Coura & Borges Pereira 1984).…”

mentioning

confidence: 59%

Chagas disease: what is known and what is needed - A background article

Coura

2007

Mem. Inst. Oswaldo Cruz

257

152

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“…Older studies of Chagas disease progression have reported cardiomyopathy in >50% of observed cases [48]. Older studies of Chagas disease progression have reported cardiomyopathy in >50% of observed cases [48].…”

Section: Frequency Of Cardiovascular Sequelamentioning

confidence: 99%

The Burden of Chagas Disease: Estimates and Challenges

2015

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Chagas disease, caused by infection with the protozoa Trypanosoma cruzi is transmitted most often by Triatominae insect vectors, but also through blood transfusion, organ transplant, and congenital transmission. Between 5 and 18 million people are currently infected and the infection is estimated to cause more than 10,000 deaths annually. The disease has 3 phases: acute, indeterminate, and chronic. The acute phase immediately follows infection. It is typically asymptomatic but produces fever and malaise in up to 5% of people. The indeterminate phase is asymptomatic. More than one-half of those infected will remain in this phase for life and never experience long-term sequelae. After a decade or more, 20% to 30% of people will experience chronic cardiovascular Chagas disease with sequelae including heart failure, arrhythmias, and thromboembolism. Another 15% to 20% will experience chronic digestive sequela including megaesophagus and megacolon. A complete accounting of the burden of Chagas disease requires estimating the prevalence of the infection, the prevalence of each of its sequelae among those with the infection, and the number of deaths attributable to the infection. Attempts to estimate Chagas disease prevalence are complicated by several challenges imposed by the disease's extreme spatial heterogeneity, quickly evolving temporal trends, the decades-long lag between infection and symptomatic disease, biased prevalence data, incomplete recognition of Chagas-attributable deaths, limited data on sequela, and a near total absence of data outside of endemic countries. Even though researchers have found methodological approaches to dealing with these challenges, there is a need for better data.

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A follow-up evaluation of Chagas' disease in two endemic areas Brazil

Cited by 14 publications

References 0 publications

Indeterminate form of Chagas disease

Indeterminate form of Chagas disease

Chagas disease: what is known and what is needed - A background article

The Burden of Chagas Disease: Estimates and Challenges

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